Results 91 to 100 of about 8,634 (215)

A New Stage and Classification of Osteonecrosis of the Femoral Head Based on MRI With Pathophysiological Interpretation

Orthopaedic Surgery, EarlyView.
An MRI‐based classification system integrating fibrosis extent (F1–F3) and inflammatory bone marrow edema activity (E0–E3) was developed for osteonecrosis of the femoral head (ONFH). Increasing fibrosis and edema severity were associated with higher collapse risk, worse pain, and poorer hip function.
Mengran Shen, Hongxu Li, Haoyang Liu, Qihan Ma, Bailiang Wang, Liming Cheng, Jinhui Ma   +6 more
wiley   +1 more source

The role of neutrophils in the pathophysiology of inflammatory bowel diseases

Periodontology 2000, EarlyView.
Abstract Objectives Inflammatory bowel disease (IBD) encompasses a spectrum of chronic disorders of the gastrointestinal tract, with a potential bidirectional relationship with periodontitis. Neutrophils are key regulators of immune‐inflammatory responses and play a major role in both diseases.
Joao Paulo Steffens, Ekin Yay‐Kus, Rafael Scaf de Molon, Viorelia Stoica, Peter Rimmer, Josefine Hirschfeld, Asif Jilani Iqbal, Tariq Iqbal, Iain Chapple   +8 more
wiley   +1 more source

Immunohistochemical Evaluation of TLR‐4, HSP‐70 and Caspase‐3 Expressions in Lesional Areas of Ecthyma Disease

Veterinary Dermatology, EarlyView.
Background: Contagious ecthyma (Orf) is a highly contagious, economically significant disease affecting sheep, goats and wild small ruminants, caused by the resilient Orf virus (ORFV). It produces thick, crusted lesions around the mouth and nostrils, especially in animals aged 3–4 months, sometimes causing near 100% mortality in immunocompromised young
Emine Nur Dincer, Ozlem Ozmen
wiley   +1 more source

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

, 2015
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release.
D. R. Higazi (7639901), D. J. Corkill (7639904), T. J. Vaughan (7639895), C. L. Overed-Sayer (7639856), K. J. Embrey (7639865), D. C. Lowe (7639898), K. A. Vousden (7639874), R. D. May (7634771), B. Popovic (7639892), Christopher Edward Brightling (7632470), I. C. Scott (7639841), N. J. Bond (7639859), D. G. Rees (7639853), T. Mustelin (7639910), C. E. Huntington (7639886), J. Woods (7634765), J. Xu (14896), D. A. Sims (7639868), M. A. Sleeman (7639907), R. Butler (2730304), M. R. Snaith (7639871), D. T. Chan (7639880), M. D. Strain (7639877), C. S. Veyssier (7639862), L. Rapley (7634762), S. Carmen (7639883), B. P. Kemp (7639847), E. England (7639850), J. B. Majithiya (7639844), E. S. Cohen (7595081), L. Flavell (7639889)   +30 more
core   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.

, 2013
Sepsis is a complex immune disorder with a mortality rate of 20-50% and currently has no therapeutic interventions. It is thus critical to identify and characterize molecules/factors responsible for its development.
Judy M Teale, Jyotika Sharma, Brandilyn J Binstock, Judy M. Teale (43991), Bibhuti B. Mishra (392001), Qun Li, Anthony L Steichen, Anthony L. Steichen (392002), Jyotika Sharma (359459), Bibhuti B Mishra, Dennis W Metzger, Qun Li (222962), Brandilyn J. Binstock (392003), Dennis W. Metzger (355175)   +13 more
core   +1 more source