Results 131 to 140 of about 10,647 (207)

Hypoxic Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Release Large Extracellular Vesicles That Promote a Pro‐Inflammatory Phenotype in Macrophages

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
ABSTRACT Directly post‐infarction, myocardial tissue release signals that trigger an acute inflammatory response to clear debris and initiate cardiac repair. However, prolonged inflammation may drive adverse remodelling and heart failure in the long‐term.
Margarida Viola, Renee G. C. Maas, Judy M. Lowik, Tom A. P. Driedonks, Ernest Diez Benavente, Luuk van de Schepop, Cor S. Seinen, Christian J. B. Snijders Blok, Saskia C. A. de Jager, Pieter Vader, Joost P. G. Sluijter   +10 more
wiley   +1 more source

Context-dependent release of HMGB1: cell death mode, cell type and LPS stress drive monomer and heterocomplex formation

Molecular Medicine
Background HMGB1 acts as an alarmin when released from stressed or dying cells. In vitro, HMGB1 has previously been demonstrated to readily form complexes with other molecules and through intermolecular disulfide bond formation form homodimers. Recently,
Harini Pechiappan, Rebecka Heinbäck, Sigrid Stråtveit Gravning, Kjerstin Jakobsen, Richard Davies, Cecilia Aulin, Helena Erlandsson Harris   +6 more
doaj   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Emerging roles for HMGB1 protein in immunity, inflammation, and cancer

ImmunoTargets and Therapy, 2015
Simona Martinotti, Mauro Patrone, Elia Ranzato DiSIT – Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Alessandria, Italy Abstract: High-mobility group box 1 (HMGB1) protein is a member of the highly conserved ...
Martinotti S, Patrone M, Ranzato E
doaj  

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, Volume 40, Issue 11, Page 6418-6449, November 2026.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Pinhole‐Like Central Bronchial Narrowing: A Rare Reversible Manifestation of Eosinophilic Bronchial Inflammation

Respirology Case Reports, Volume 14, Issue 11, November 2026.
Eosinophilic bronchial inflammation can cause severe central bronchial narrowing and recurrent atelectasis, even in patients with well‐controlled asthma. Endobronchial biopsy can establish the diagnosis and identify this potentially reversible, corticosteroid‐responsive condition.
Ryusuke Kizawa, Zenya Saito, Kohei Minekawa, Makiko Takatsuka, Takaaki Kitayama, Masahiro Yoshida, Takanori Numata, Jun Araya   +7 more
wiley   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, Volume 31, Issue 11, Page 1077-1090, November 2026.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series

Australasian Journal of Dermatology, Volume 67, Issue 7, Page 420-423, November 2026.
ABSTRACT We present three patients who developed allergic contact dermatitis (ACD) from benzalkonium chloride (BAK) in ophthalmic drops. BAK is a preservative commonly found in ophthalmic formulations and there is a rising trend of ACD to this allergen. The irritant and sensitising properties of BAK on the ocular mucosa will be discussed.
Arav Kannen, Penelope Harrison, Elizabeth Christou   +2 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, Volume 81, Issue 11, Page 3825-3852, November 2026.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Targeting upstream alarmins (TSLP, IL-33, IL-25): a new frontier in treating type 2 chronic rhinosinusitis with nasal polyps. [PDF]

Front Immunol
Li S.
europepmc   +1 more source