Results 61 to 70 of about 10,647 (207)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

, 2010
Granulysin (GNLY), an antimicrobial protein present in the granules of human cytotoxic T lymphocytes and natural killer (NK) cells, is produced as an intact 15-kDa form that is cleaved to yield a 9-kDa form.
Carol Clayberger, Joost J. Oppenheim, Alan M. Krensky, Michael W. Finn, Gonzalo de la Rosa, Yana Li, Poonam Tewary, De Yang   +7 more
core   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. [PDF]

, 2018
Stroke induces a multiphasic systemic immune response, but the consequences of this response on atherosclerosis-a major source of recurrent vascular events-have not been thoroughly investigated.
Roth, Stefan, Singh, Vikramjeet, Holdt, Lesca M, Bernhagen, Jürgen, Bianchi, Marco E, Engelhardt, Britta, Geerlof, Arie, Anfray, Antoine, Gauberti, Maxime, Fournier, Antoine, Antoine, Daniel J, Tiedt, Steffen, Dichgans, Martin, Orset, Cyrille, Haffner, Christof, Vivien, Denis, Huber, Georg, Schindler, Lisa, Harris, Helena Erlandsson, Liesz, Arthur   +19 more
core   +2 more sources

The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases

Frontiers in Immunology
Epithelial-derived IL-33 (Interleukin-33), as a member of alarm signals, is a chemical substance produced under harmful stimuli that can promote innate immunity and activate adaptive immune responses.
Shiyao Gu, Ruixuan Wang, Wantian Zhang, Cen Wen, Chunhua Chen, Su Liu, Qian Lei, Peng Zhang, Si Zeng   +8 more
doaj   +1 more source

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Shan Wu, Junjie Chen, Junjie Chen, Boon Heng Dennis Teo, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Seng Yin Kelly Wee, Ming Hui Millie Wong, Ming Hui Millie Wong, Jianzhou Cui, Jinmiao Chen, Jinmiao Chen, Khai Pang Leong, Jinhua Lu, Jinhua Lu   +15 more
doaj   +1 more source

Alarmin function of galectin-9 in murine respiratory tularemia.

, 2015
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis.
Jyotika Sharma, Bibhuti B Mishra, Dennis W Metzger, Anthony L Steichen, Tanner J Simonson, Sharon L Salmon, Simonson Tanner J., Mishra Bibhuti B., Sharma Jyotika, Steichen Anthony L., Salmon Sharon L., Metzger Dennis W.   +11 more
core   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.

, 2012
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined.
Schrick, Christina, Fröhlich, Anja, Bonilla, Weldy V., Senn, K., Klemenz, R., Johnson, S., Klemenz, Roman, Löhning, M., Fallon, Padraic G., Kreutzfeldt, M., Hegazy, A.N., Fernandez, M., Merkler, D., Bonilla, Weldy V, Löhning, Max, Fallon, Padraic G, Nakae, S., Kallert, Sandra, Pinschewer, D.D., Hegazy, Ahmed N, Schrick, C., Adler, Heiko, Kallert, S., Kreutzfeldt, Mario, Merkler, Doron, Bonilla, W.V., Fallon, P.G., Pinschewer, Daniel, Froehlich, Anja, Fröhlich, A., Nakae, Susumu, Pinschewer, Daniel D., Loehning, Max, Adler, H., Hegazy, Ahmed N., Fernandez, Marylise, Johnson, Susan, Senn, Karin, Merkler D, Adler H, Kallert S, Löhning M, Senn K, Kreutzfeldt M, Klemenz R, Johnson S, Bonilla WV, Pinschewer DD, Fröhlich A, Fallon PG, Fernandez M, Schrick C, Nakae S, Hegazy AN   +53 more
core   +1 more source

Nuclear Alarmin Cytokines in Inflammation

, 2020
Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Yao Tian, Yijia Shao, Changsheng Ouyang, Xiaohua Wang, Lili Jiang   +4 more
core   +1 more source