Results 61 to 70 of about 8,634 (215)

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Nonspecific cytotoxic cell antimicrobial protein (NCAMP-1): a novel alarmin ligand identified in zebrafish.

, 2015
Cells from the coelomic cavity of adult zebrafish (zf) were used to study the alarmin-like activities of nonspecific cytotoxic cell antimicrobial protein-1 (NCAMP-1).
Krunkosky Thomas, Donald Lee Evans, Monette Margaret Mariscal, Margaret Mariscal Monette, Liliana Jaso-Friedmann, Camus Alvin, Thomas Krunkosky, Alvin Camus, Evans Donald Lee, Jaso-Friedmann Liliana   +9 more
core   +1 more source

Evaluating the Potential Infectious Risk Profile of Biologics in Chronic Rhinosinusitis With Nasal Polyposis

International Forum of Allergy &Rhinology, EarlyView.
Maxime Fieux, Philippe Gevaert, Leigh J. Sowerby   +2 more
wiley   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

, 2018
Interleukin (IL)-33 is an IL-1 family alarmin released from damaged epithelial and endothelial barriers to elicit immune responses and allergic inflammation via its receptor ST2.
Ian C. Scott, Molly Guscott, Dominic J. Corkill, Sanden, Caroline, Corkill, Dominic J.,, Erjefält, Jonas S., Majithiya, Jayesh B.,, Cohen, E. Suzanne, Tom Moore, Peter Thornton, E. Suzanne Cohen, Thornton, Peter, Scott, Ian C., Moore, Tom, Jayesh B. Majithiya, Moore, Tom,, Sanden, Caroline,, Sanders, Philip N., Cohen, E. Suzanne,, Corkill, Dominic J., Sanders, Philip N.,, Philip N. Sanders, Thornton, Peter,, Scott, Ian C.,, Guscott, Molly,, Erjefält, Jonas S.,, Jonas S. Erjefält, Guscott, Molly, Lund University., Caroline Sanden, Majithiya, Jayesh B.   +30 more
core   +1 more source

S100A8 alarmin supports IL-6 and metalloproteinase-9 production by fibroblasts in the synovial microenvironment of peripheral spondyloarthritis

, 2023
INTRODUCTION: Spondyloarthritis (SpA) is a common autoinflammatory disease. S100A8/ S100A9 alarmin is strongly expressed in the synovial sublining layers of psoriatic arthritis. S100A8/ S100A9 is the most abundant protein in rheumatoid arthritis synovial
Páez, María D., Arias, José L., Arias, Jose Luis, Callegari, Eduardo Alberto, Eliçabe, Ricardo Javier, Di Genaro, Maria Silvia, Pardo Hidalgo, Rodolfo, Funes, Samanta C., Eliçabe, Ricardo J., Munarriz, Alicia, Blas, Rodrigo, Di Genaro, María S., Funes, Samanta Celeste, Callegari, Eduardo, Pardo-Hidalgo, Rodolfo, Tamashiro, Héctor   +15 more
core   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

The Impact of Invariant NKT Cells in Sterile Inflammation: The Possible Contribution of the Alarmin/Cytokine IL-33 [PDF]

, 2018
Although the contribution of iNKT cells to induction of sterile inflammation is now well-established, the nature of the endogenous compounds released early after cellular stress or damage that drive their activation and recruitment remains poorly ...
Aurélie Robin, Antoine Thierry, Thierry, Antoine, Jean-Marc Gombert, André Herbelin, Louise Barbier, Herbelin, André, Ferhat, Maroua Haroun, Barbarin, Alice, Robin, Aurélie, Alice Barbarin, Maroua Haroun Ferhat, Barbier, Louise, Gombert, Jean-Marc   +13 more
core   +1 more source

Chromatin as alarmins in necrotizing enterocolitis

Frontiers in Immunology
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting premature neonates, marked by poorly understood pro-inflammatory signaling cascades. Recent advancements have shed light on a subset of endogenous molecular patterns, termed chromatin-associated molecular patterns (CAMPs), which belong to the broader category of ...
Colleen P. Nofi, Colleen P. Nofi, Colleen P. Nofi, Jose M. Prince, Jose M. Prince, Ping Wang, Ping Wang, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz, Monowar Aziz, Monowar Aziz   +12 more
openaire   +3 more sources