Results 31 to 40 of about 1,269 (186)
Alarmins and Antitumor Immunity [PDF]
Clinical Therapeutics, 2016 Alarmins are constitutively present endogenous molecules that essentially act as early warning signals for the immune system. We provide a brief overview of major alarmins and highlight their roles in tumor immunity.We searched PubMed up to January 10, 2016, using alarmins and/or damage-associated molecular patterns (DAMPs), as key words.
Yingjie, Nie +2 more
openaire +2 more sources
Alarmins and antimicrobial immunity [PDF]
Medical Mycology, 2009 Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of ...
D, Yang, J J, Oppenheim
openaire +2 more sources
Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis
Acta Medica, 2022 Background. Psoriasis is a chronic systemic inflammatory disease with (extra-)cutaneous manifestations. Inflammation is associated with cellular stress and tissue damage which lead to the release of alarmins (signals of danger).
Drahomíra Holmannová +10 more
doaj +1 more source
Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation
Frontiers in Immunology, 2015 Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
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S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation
Frontiers in Immunology, 2020 The restricted capacity of newborn infants to mount inflammatory responses toward microbial challenges has traditionally been linked to the high risk of septic diseases during the neonatal period.
Dorothee Viemann +2 more
doaj +1 more source
The GAR/RGG motif defines a family of nuclear alarmins
Cell Death and Disease, 2021 The nucleus is the target of autoantibodies in many diseases, which suggests intrinsic nuclear adjuvants that confer its high autoimmunogenicity. Nucleolin (NCL) is one abundant nucleolar autoantigen in systemic lupus erythematosus (SLE) patients and, in
Shan Wu +4 more
doaj +1 more source
Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jemima Ho +5 more
doaj +1 more source
Multifunctional Role of S100 Protein Family in the Immune System: An Update
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
doaj +1 more source
Tumors Sound the Alarmin(s) [PDF]
Cancer Research, 2008 Abstract Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology.
Seth B, Coffelt, Aline B, Scandurro
openaire +2 more sources
Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out
Cells, 2023 Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode switch in serum-starving or ischemic/reperfusion models in vitro and in vivo.
Hiroshi Ueda
doaj +1 more source