Results 31 to 40 of about 10,508 (186)

Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation

Frontiers in Immunology, 2015
Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
doaj   +1 more source

Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy [PDF]

, 2022
Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events.
Antohe, Felicia, Elena Uyy, Ivan, Luminita, Aurel Cerveanu-Hogas, Felicia Antohe, Rune Hansen, Cerveanu-Hogas, Aurel, Raluca M. Boteanu, Suica, Viorel I., Boteanu, Raluca M., Viorel I. Suica, Luminita Ivan, Hansen, Rune, Uyy, Elena   +13 more
core   +1 more source

Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out

Cells, 2023
Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode switch in serum-starving or ischemic/reperfusion models in vitro and in vivo.
Hiroshi Ueda
doaj   +1 more source

Alarmins: awaiting a clinical response.

, 2012
Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes ...
Joost J. Oppenheim, Nanchahal, Jagdeep, Roth, Johannes, Nicole Horwood, Jagdeep Nanchahal, Oppenheim, Joost J, Tracey, Kevin J, Vogl, Thomas, Horwood, Nicole, Thomas Vogl, Marc Feldmann, Johannes Roth, James K. Chan, Feldmann, Marc, Chan, James K, Kevin J. Tracey   +15 more
core   +1 more source

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis [PDF]

, 2021
A major pathway for proinflammatory protein release by macrophages is inflammasome-mediated pyroptotic cell death. As conventional secretion, unconventional secretion, and cell death are executed simultaneously, however, the cellular mechanisms ...
Phulphagar, Kshiti, Frauenstein, Annika, Rieckmann, J., Swietlik, J., Meissner, F., Ebner, S., Phulphagar, K., Frauenstein, A., Rieckmann, Jan, Meissner, Felix, Swietlik, Jonathan J., Kuehn, L., Kühn, Lars I., Ebner, Stefan, Stefan Ebner, Lars I. Kühn, Jan Rieckmann, Kshiti Phulphagar, Annika Frauenstein, Felix Meissner, Jonathan J. Swietlik   +20 more
core   +1 more source

Nuclear Alarmin Cytokines in Inflammation

Journal of Immunology Research, 2020
Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Lili Jiang, Yijia Shao, Yao Tian, Changsheng Ouyang, Xiaohua Wang   +4 more
doaj   +1 more source

Glucose Induces IL-1α-Dependent Inflammation and Extracellular Matrix Proteins Expression and Deposition in Renal Tubular Epithelial Cells in Diabetic Kidney Disease

Frontiers in Immunology, 2020
Diabetes mellitus is linked with metabolic stress that induces cellular damage and can provoke renal inflammation and fibrotic responses that eventually lead to chronic kidney disease. Because the inflammasome, interleukin 1 (IL-1), IL-1α/IL-β, and IL-1R
Talal Salti, Khaled Khazim, Khaled Khazim, Khaled Khazim, Rami Haddad, Salvatore Campisi-Pinto, Gil Bar-Sela, Gil Bar-Sela, Idan Cohen   +8 more
doaj   +1 more source

Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook [PDF]

, 2023
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive inflammatory airway disease associated with a significant impact on patients' lives, including morbidity and mortality, and significant healthcare costs.
Amr Radwan, Bafadhel, Mona; id_orcid, Xavier Soler, Klaus F. Rabe, Martinez, Fernando J., Papi, Alberto, Juby A. Jacob Nara, Rowe, Paul J., Paul J. Rowe, Bafadhel, Mona, Jigna Heble, Jacob Nara, Juby A., Soler, Xavier, Singh, Dave, Martinez, Fernando J, Mona Bafadhel, Bartolome R. Celli, Radwan, Amr, Deniz, Yamo, Dave Singh, Rabe, Klaus F., Fernando J. Martinez, Rennard, Stephen, Rowe, Paul J, Stephen Rennard, Celli, Bartolome R., Alberto Papi, Celli, Bartolome R, Yamo Deniz, Heble, Jigna, Rabe, Klaus F, Jacob Nara, Juby A   +31 more
core   +1 more source

Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin

Cells, 2022
Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts ...
Luc Rochette, Geoffrey Dogon, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source