Results 21 to 30 of about 10,508 (186)
The Role of Alarmins in the Pathogenesis of Atherosclerosis and Myocardial Infarction
Current Issues in Molecular BiologyAtherosclerosis is a condition that is associated with lipid accumulation in the arterial intima. Consequently, the enlarging lesion, which is also known as an atherosclerotic plaque, may close the blood vessel lumen, thus leading to organ ischaemia ...
Kajetan Kiełbowski +4 more
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Alarmins/stressorins and immune dysregulation in intractable skin disorders
Allergology International, 2021 Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults ...
Kiyofumi Yamanishi, Yasutomo Imai
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The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury
Frontiers in Medicine, 2020 Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain immune ...
Vikram Sabapathy +3 more
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Gastric alarmin release: A warning signal in the development of gastric mucosal diseases
Frontiers in Immunology, 2022 Alarmins exist outside cells and are early warning signals to the immune system; as such, alarmin receptors are widely distributed on various immune cells.
Enqin Wu +7 more
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Goeckerman Regimen Reduces Alarmin Levels and PASI Score in Paediatric Patients with Psoriasis
Acta Medica, 2022 Background. Psoriasis is a chronic systemic inflammatory disease with (extra-)cutaneous manifestations. Inflammation is associated with cellular stress and tissue damage which lead to the release of alarmins (signals of danger).
Drahomíra Holmannová +10 more
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, 2017 Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the
Charles A. Dinarello +4 more
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Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells
Cells, 2020 Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to ...
Jemima Ho +5 more
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The GAR/RGG motif defines a family of nuclear alarmins
Cell Death and Disease, 2021 The nucleus is the target of autoantibodies in many diseases, which suggests intrinsic nuclear adjuvants that confer its high autoimmunogenicity. Nucleolin (NCL) is one abundant nucleolar autoantigen in systemic lupus erythematosus (SLE) patients and, in
Shan Wu +4 more
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S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation
Frontiers in Immunology, 2020 The restricted capacity of newborn infants to mount inflammatory responses toward microbial challenges has traditionally been linked to the high risk of septic diseases during the neonatal period.
Dorothee Viemann +2 more
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Multifunctional Role of S100 Protein Family in the Immune System: An Update
Cells, 2022 S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with structural similarity and functional discrepancy. It is required for inflammation and cellular homeostasis, and can work extracellularly, intracellularly, or both.
Parul Singh, Syed Azmal Ali
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