Results 21 to 30 of about 1,269 (186)
Role of alarmins in the pathogenesis of systemic sclerosis [PDF]
International Journal of Molecular Sciences, 2020 Systemic sclerosis (SSc) is a rare chronic autoimmune disease associated with significant morbidity and mortality. Two main subsets of SSc are recognized: (i) diffuse cutaneous SSc with rapidly progressive fibrosis of the skin, lungs, and other internal ...
Casciaro M. +5 more
core +8 more sources
The Involvement of Alarmins in the Pathogenesis of Sjögren’s Syndrome [PDF]
International Journal of Molecular Sciences, 2022 Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects exocrine glands, primarily the salivary and lachrymal glands. It is characterized by lymphoplasmacytic infiltration of the glandular tissues, ultimately leading to their dysfunction and
Dorian Parisis +8 more
core +3 more sources
Alarmins, inflammasomes and immunity
Biomedical Journal, 2012 The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern ...
Ojcius, David M. +3 more
core +4 more sources
Frontiers in Immunology, 2019 Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk ...
Bartijn C. H. Pieters +5 more
doaj +2 more sources
The Role of Alarmins in the Pathogenesis of Atherosclerosis and Myocardial Infarction
Current Issues in Molecular BiologyAtherosclerosis is a condition that is associated with lipid accumulation in the arterial intima. Consequently, the enlarging lesion, which is also known as an atherosclerotic plaque, may close the blood vessel lumen, thus leading to organ ischaemia ...
Kajetan Kiełbowski +4 more
doaj +2 more sources
Sounding the alarmins—The role of alarmin cytokines in asthma
Allergy, 2022 AbstractThe alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2
Gail M. Gauvreau +9 more
openaire +2 more sources
Alarmins/stressorins and immune dysregulation in intractable skin disorders
Allergology International, 2021 Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults ...
Kiyofumi Yamanishi, Yasutomo Imai
doaj +1 more source
Immunological Reviews, 2017 SummaryMore than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host ...
De Yang, Zhen Han, Joost J. Oppenheim
openaire +2 more sources
Gastric alarmin release: A warning signal in the development of gastric mucosal diseases
Frontiers in Immunology, 2022 Alarmins exist outside cells and are early warning signals to the immune system; as such, alarmin receptors are widely distributed on various immune cells.
Enqin Wu +7 more
doaj +1 more source
The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury
Frontiers in Medicine, 2020 Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain immune ...
Vikram Sabapathy +3 more
doaj +1 more source