A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies [PDF]
Clinical and Translational AllergyImmune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders.
Stefania Isola +5 more
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Promoting immune defensive responses of epithelial cells in airway disease [PDF]
Frontiers in AllergyThe airway epithelium serves as both a physical barrier and as an active contributor in maintaining immune defense. Upon exposure to external insults such as injury and infection, the epithelium releases alarmins including interleukin-25 (IL-25), IL-33 ...
Michael J. Parnham +2 more
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Enhanced Alarmin Secretion Exacerbates Neutrophil Extracellular Trap (NET) Formation in Active Psoriasis: Implication of IL-33 and TSLP in Driving NET Formation, Inflammation and Oxidative Stress in Psoriasis [PDF]
AntioxidantsPsoriasis is a common inflammatory skin disease with chronic manifestation in which the role of neutrophil extracellular traps (NETs) and alarmins are increasingly recognized as contributors to systemic and cutaneous inflammation.
Vanshika Ojha +2 more
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Macrophage-Derived Extracellular Vesicles as Carriers of Alarmins and Their Potential Involvement in Bone Homeostasis [PDF]
Frontiers in Immunology, 2019 Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosstalk ...
Bartijn C. H. Pieters +5 more
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The Role of Alarmins in the Pathogenesis of Atherosclerosis and Myocardial Infarction [PDF]
Current Issues in Molecular BiologyAtherosclerosis is a condition that is associated with lipid accumulation in the arterial intima. Consequently, the enlarging lesion, which is also known as an atherosclerotic plaque, may close the blood vessel lumen, thus leading to organ ischaemia ...
Kajetan Kiełbowski +4 more
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Sounding the alarmins—The role of alarmin cytokines in asthma
Allergy, 2022 AbstractThe alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2
Gail M. Gauvreau +9 more
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Alarmins/stressorins and immune dysregulation in intractable skin disorders
Allergology International, 2021 Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults ...
Kiyofumi Yamanishi, Yasutomo Imai
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Immunological Reviews, 2017 SummaryMore than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host ...
De Yang, Zhen Han, Joost J. Oppenheim
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The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury
Frontiers in Medicine, 2020 Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain immune ...
Vikram Sabapathy +3 more
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Gastric alarmin release: A warning signal in the development of gastric mucosal diseases
Frontiers in Immunology, 2022 Alarmins exist outside cells and are early warning signals to the immune system; as such, alarmin receptors are widely distributed on various immune cells.
Enqin Wu +7 more
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