Results 11 to 20 of about 1,269 (186)
Alarmins: Feel the Stress [PDF]
The Journal of Immunology, 2017 Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the
Charles A. Dinarello +4 more
core +4 more sources
International Journal of Molecular Sciences, 2023 It is well ascertained that airway inflammation has a key role in the genesis of numerous respiratory pathologies, including asthma, chronic obstructive pulmonary disease, and acute respiratory distress syndrome.
Alessandro Allegra +2 more
exaly +3 more sources
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets
BiomedicinesAsthma is a chronic respiratory condition predominantly driven by a type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells and ...
Ravneet K. Hansi +3 more
doaj +2 more sources
Journal of Clinical Medicine, 2023 Food allergies are immuno-mediated adverse reactions to ingestion or contact with foods, representing a widespread health problem. The immune response can be IgE-mediated, non-IgE-mediated, or with a mixed mechanism.
Angela Rizzi +2 more
exaly +2 more sources
Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?
Biomolecules, 2018 Autism spectrum disorders (ASDs) represent a disabling condition in early childhood. A number of risk factors were proposed in order to explain their pathogenesis.
Eleonora Di Salvo +4 more
doaj +2 more sources
Targeting Type 2 Inflammation and Epithelial Alarmins in Chronic Obstructive Pulmonary Disease: A Biologics Outlook [PDF]
American Journal of Respiratory and Critical Care Medicine, 2023 Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive inflammatory airway disease associated with a significant impact on patients' lives, including morbidity and mortality, and significant healthcare costs.
Klaus F Rabe +2 more
exaly +2 more sources
Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases
Frontiers in Immunology, 2019 Autoimmune and auto-inflammatory diseases in children are causing chronic inflammation, organ damage, and pain. Although several options for treatment are nowadays available a significant number of patients does not respond sufficiently to current ...
Dirk Holzinger +2 more
exaly +3 more sources
Alarmins: awaiting a clinical response. [PDF]
Journal of Clinical Investigation, 2012 Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes ...
Tracey, KJ +24 more
core +4 more sources
Alarmins in tendinopathy: unravelling new mechanisms in a common disease
Rheumatology, 2013 Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care in the UK and account for up to 30% of rheumatological consultations.
Neal L Millar +2 more
exaly +2 more sources
Nuclear Alarmin Cytokines in Inflammation [PDF]
Journal of Immunology Research, 2020 Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Lili Jiang +4 more
doaj +3 more sources