Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis [PDF]
ERJ Open ResearchPulmonary fibrosis is a chronic respiratory disorder characterised by an overproduction and aberrant deposition of fibrotic tissue in the lungs. This narrative review focuses on the pivotal role played by epithelial alarmins, primarily thymic stromal ...
Tommaso Pianigiani +8 more
doaj +3 more sources
Alarmins differentially modulate airway contraction and relaxation of human small airways [PDF]
Respiratory ResearchAlarmins, including Thymic Stromal Lymphopoietin (TSLP) and Interleukins 33 and 25 (IL-33 and IL-25), contribute to the pathophysiology of allergic and nonallergic asthma by evoking exacerbations in response to allergens, viruses, and environmental ...
Joshua L. Kennedy +3 more
doaj +2 more sources
Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
Mediators of Inflammation, 2020 Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic ...
Pavel Borsky +10 more
doaj +2 more sources
Alarmins in Tendinopathy: Unravelling New Mechanisms in a Common Disease.
Rheumatology, 2013 Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care in the UK and account for up to 30% of rheumatological consultations.
Neal L. Millar +2 more
exaly +5 more sources
Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression?
Biomolecules, 2018 Autism spectrum disorders (ASDs) represent a disabling condition in early childhood. A number of risk factors were proposed in order to explain their pathogenesis.
Eleonora Di Salvo +4 more
doaj +3 more sources
Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases
Frontiers in Immunology, 2019 Autoimmune and auto-inflammatory diseases in children are causing chronic inflammation, organ damage, and pain. Although several options for treatment are nowadays available a significant number of patients does not respond sufficiently to current ...
Johannes Roth +2 more
exaly +3 more sources
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets
BiomedicinesAsthma is a chronic respiratory condition predominantly driven by a type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells and ...
Ravneet K. Hansi +3 more
doaj +2 more sources
Association of Epithelial Alarmins and Th2 Cytokines with Disease Severity in Non-Cystic Fibrosis Bronchiectasis [PDF]
MedicinaBackground and Objectives: Alarmins and Th2-driven inflammatory pathways may contribute to disease severity, exacerbation frequency, and mortality; however, their role in non-cystic fibrosis bronchiectasis remains insufficiently defined. This study aimed
Okan Gurbuz +6 more
doaj +2 more sources
Early Growth Response 1‐Associated Epithelial Autophagy‐Related Changes in Allergic Airway Inflammation [PDF]
Pediatric Discovery, EarlyView.House dust mite (HDM) exposure induces early growth response 1 (EGR1) expression in airway epithelial cells and is accompanied by autophagy‐associated alterations, including increased LC3B‐II and Vps34 levels and decreased p62 abundance. Manipulation of EGR1 expression modulates these autophagy‐related changes, whereas pharmacological inhibition of ...
Xinyang Wang +3 more
wiley +2 more sources
Circulating levels of high mobility group box-1 and nucleophosmin/B23 proteins and clinical significance in debut non-small cell lung cancer patients [PDF]
Scientific ReportsAlarmins are endogenous molecules that alert the immune system to circumvent the invading antigens in the host. Here, we investigated the serum levels of the high mobility group box 1 (HMGB-1) and nucleophosmin alarmins in a cohort of 162 newly diagnosed
Hui Tan +8 more
doaj +2 more sources