Results 11 to 20 of about 9,358 (229)
Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris [PDF]
Mediators of Inflammation, 2020 Background. Psoriasis vulgaris is a chronic autoimmune disease associated with systemic inflammation. Increased levels of numerous cytokines, chemokines, growth factors, and other molecules were found in the skin and in the circulation of psoriatic ...
Pavel Borsky +10 more
doaj +2 more sources
Circulating levels of high mobility group box-1 and nucleophosmin/B23 proteins and clinical significance in debut non-small cell lung cancer patients [PDF]
Scientific ReportsAlarmins are endogenous molecules that alert the immune system to circumvent the invading antigens in the host. Here, we investigated the serum levels of the high mobility group box 1 (HMGB-1) and nucleophosmin alarmins in a cohort of 162 newly diagnosed
Hui Tan +8 more
doaj +2 more sources
Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis [PDF]
ERJ Open ResearchPulmonary fibrosis is a chronic respiratory disorder characterised by an overproduction and aberrant deposition of fibrotic tissue in the lungs. This narrative review focuses on the pivotal role played by epithelial alarmins, primarily thymic stromal ...
Tommaso Pianigiani +8 more
doaj +2 more sources
Regulation of Airway Epithelial-Derived Alarmins in Asthma: Perspectives for Therapeutic Targets [PDF]
BiomedicinesAsthma is a chronic respiratory condition predominantly driven by a type 2 immune response. Epithelial-derived alarmins such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, and IL-25 orchestrate the activation of downstream Th2 cells and ...
Ravneet K. Hansi +3 more
doaj +2 more sources
Role of Alarmins in the Pathogenesis of Systemic Sclerosis [PDF]
International Journal of Molecular Sciences, 2020 Systemic sclerosis (SSc) is a rare chronic autoimmune disease associated with significant morbidity and mortality. Two main subsets of SSc are recognized: (i) diffuse cutaneous SSc with rapidly progressive fibrosis of the skin, lungs, and other internal organs; and (ii) limited cutaneous SSc, which is dominated by vascular manifestations, with skin and
Antonello Giovannetti +5 more
core +10 more sources
Do Alarmins Have a Potential Role in Autism Spectrum Disorders Pathogenesis and Progression? [PDF]
Biomolecules, 2018 Autism spectrum disorders (ASDs) represent a disabling condition in early childhood. A number of risk factors were proposed in order to explain their pathogenesis.
Eleonora Di Salvo +4 more
doaj +2 more sources
The Involvement of Alarmins in the Pathogenesis of Sjögren’s Syndrome [PDF]
International Journal of Molecular Sciences, 2022 Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects exocrine glands, primarily the salivary and lachrymal glands. It is characterized by lymphoplasmacytic infiltration of the glandular tissues, ultimately leading to their dysfunction and destruction. Besides classic dry eyes and dry mouth defined as sicca syndrome, patients affected by
Julie Sarrand +3 more
openaire +4 more sources
Alarmins, inflammasomes and immunity [PDF]
Biomedical Journal, 2012 The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs).
Najwane Saïd-Sadier, David M Ojcius
openaire +4 more sources
Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases
Frontiers in Immunology, 2019 Autoimmune and auto-inflammatory diseases in children are causing chronic inflammation, organ damage, and pain. Although several options for treatment are nowadays available a significant number of patients does not respond sufficiently to current ...
Johannes Roth +2 more
exaly +3 more sources
Nuclear Alarmin Cytokines in Inflammation [PDF]
Journal of Immunology Research, 2020 Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and ...
Lili Jiang +4 more
doaj +3 more sources