Results 81 to 90 of about 10,508 (186)

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +2 more sources

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. [PDF]

, 2018
Stroke induces a multiphasic systemic immune response, but the consequences of this response on atherosclerosis-a major source of recurrent vascular events-have not been thoroughly investigated.
Singh, Vikramjeet, Huber, G., Stefan Roth, Gauberti, M., Bianchi, Marco E., Gauberti, Maxime, Helena Erlandsson Harris, Antoine Anfray, Georg Huber, Tiedt, Steffen, Maxime Gauberti, Huber, Georg, Daniel J. Antoine, Holdt, Lesca M., Orset, C., Bernhagen, Jürgen, Christof Haffner, Engelhardt, Britta, Harris, H.E., Britta Engelhardt, Antoine, Daniel J., Martin Dichgans, Marco E. Bianchi, Bianchi, M.E., Vivien, D., Roth, Stefan, Schindler, L., Holdt, L.M., Engelhardt, B., Cyrille Orset, Bianchi, Marco E, Fournier, A., Geerlof, Arie, Fournier, Antoine, Orset, Cyrille, Geerlof, A., Bernhagen, J., Vivien, Denis, Lesca M. Holdt, Liesz, A., Schindler, Lisa, Anfray, A., Harris, Helena Erlandsson, Liesz, Arthur, Denis Vivien, Steffen Tiedt, Jürgen Bernhagen, Holdt, Lesca M, Vikramjeet Singh, Arthur Liesz, Haffner, C., Singh, V.K., Antoine Fournier, Antoine, D.J., Anfray, Antoine, Antoine, Daniel J, Dichgans, Martin, Tiedt, S., Haffner, Christof, Lisa Schindler, Roth, S., Arie Geerlof, Dichgans, M., Geerlof A, Roth, S, Huber G, Schindler L, Antoine DJ, Haffner C, Singh V, Holdt LM, Harris HE, Anfray, A, Singh, V, Dichgans M, Anfray A, Vivien D, Roth S, Tiedt, S, Geerlof, A, Tiedt S, Fournier A, Antoine, DJ, Huber, G, Bianchi ME, Bernhagen J, Engelhardt B, Orset, C, Schindler, L, Gauberti M, Orset C, Liesz A, Gauberti, M   +92 more
core   +1 more source

Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis

Allergy, EarlyView.
Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross, Lukas Bäriswyl, Erik Kupschke, Alexandra Wallimann, Hanne Hillen, Philipp Kirchner, Jivko Kamarashev, Martin Wartenberg, Claudio Rhyner, Christoph Schlapbach, Stephan Traidl, Mirjam Schenk   +11 more
wiley   +1 more source

Correlation Between Plasma High Mobility Group Protein N1 Level and the Prognosis of Patients with Acute Cerebral Infarction: Preliminary Findings

Neuropsychiatric Disease and Treatment, 2022
Yufeng Lin,1 Kaiyuan Wang,2 Daowen Ji,1 Zhongying Gong,1 Zhiyun Wang1 1Department of Neurology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Department of Anesthesiology ...
Lin Y, Wang K, Ji D, Gong Z, Wang Z
doaj  

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Promoting immune defensive responses of epithelial cells in airway disease

Frontiers in Allergy
The airway epithelium serves as both a physical barrier and as an active contributor in maintaining immune defense. Upon exposure to external insults such as injury and infection, the epithelium releases alarmins including interleukin-25 (IL-25), IL-33 ...
Michael J. Parnham, Virginia Norris, Jennifer A. Kricker   +2 more
doaj   +1 more source

Anti-alarmins in asthma:targeting the airway epithelium with next-generation biologics

, 2020
Monoclonal antibody therapies have significantly improved treatment outcomes for patients with severe asthma; however, a significant disease burden remains. Available biologic treatments, including anti-immunoglobulin (Ig)E, anti-interleukin (IL)-5, anti-
Sverrild, Asger, Lloyd, Clare M, Porsbjerg, Celeste M, Bel, Elisabeth H, Menzies-Gow, Andrew N   +4 more
core   +1 more source

Targeting alarmins to accelerate healing [PDF]

, 2017
Promoting tissue repair in adults represents a major unmet medical need. Tissue regeneration relies on the activation of quiescent endogenous stem cells and whilst considerable progress has been made, novel therapies based on stem cells have thus far ...

core   +1 more source

Identification of epithelial alarmins that promote activation of primary human lung fibroblasts [PDF]

, 2013
PhD ThesisBackground Activation of the innate immune system plays a key role in exacerbations of chronic lung disease, yet the role of fibroblasts in innate immune responses and the identity of danger signals (alarmins) that may contribute to their ...
Suwara, Monika Iwona
core