Results 101 to 110 of about 10,508 (186)

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Reactive Astrocyte‐Associated IL‐33 Signaling Contributes to a Protective Neuroimmune State During Chronic Toxoplasma gondii–Plasmodium berghei Coinfection

Glia, Volume 75, Issue 1, January 2027.
Chronic Toxoplasma gondii infection establishes a regulated neuroimmune environment that protects against experimental cerebral malaria without reducing cerebral parasite burden. Coinfection is associated with the emergence of reactive astrocytes displaying an intermediate inflammatory phenotype characterized by the co‐expression of CXCL‐10 and TGF‐β ...
Inès Leleu, Tarun Keswani, Fabien Herbert, Capucine Picavet, Manon Arnaud, Sabrina Marion, Corine Glineur, Sylviane Pied   +7 more
wiley   +1 more source

Established Tissue Eosinophilia is Not Synonymous With Ongoing Local Type 2 Cytokine Activity

Allergy, EarlyView.
Franziska U. Nordström, Malin Lindstedt, Lennart Greiff, Jonas S. Erjefält   +3 more
wiley   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

Multi‐Organ Inflammatory and Endocrine Crosstalk Shapes the Early Brain Response to Combined Burn and Blast Injury

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Concomitant burn injury and blast‐induced mild TBI lead to a magnified neuroimmune response shaped by endocrine stress‐related pathways and IL‐1R1‐dependent inflammatory signals, which also produce cytokine‐mediated impairment of erythropoiesis. These integrated systemic and CNS responses illustrate how inflammation, hematopoietic adaptation, and early
Hana C. Schwierling, Satarupa Sengupta, John G. Noel, Christopher J. O'Connell, Andrew S. Potter, Mike Adam, Matthew J. Robson, Jason C. Gardner   +7 more
wiley   +1 more source

Regulation of IL‐13 Signaling by Retinoic Acid in Airway Epithelial Cells

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Our proteomics and subsequent biochemical analyses reveal the effects of retinoic acid receptor (RAR) agonists, ATRA (pan‐RAR agonist), or CD1530 (RARγ agonist) in counteracting molecular changes induced by IL‐13 relevant to airway inflammation and remodeling, such as proteins involved in epithelial‐to‐mesenchymal transition (EMT) and extracellular ...
Vanshika Patel, Jianshi Yu, Mehari Weldemariam, Paul Shapiro, Deepak A. Deshpande, Maureen A. Kane   +5 more
wiley   +1 more source

The Roles of Innate Immune Cells in Atopic Dermatitis

Journal of Innate Immunity
Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has
Yuke Pan, Youyi Wang, Meinian Xu, Meizhen Zhong, Xiaoming Peng, Kang Zeng, Xiaowen Huang   +6 more
doaj   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1269-1279, November 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability

Frontiers in Cell and Developmental Biology
In Alzheimer’s Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau, may act as alarmins/damage-associated molecular patterns (DAMPs) to stimulate neuroinflammation and cell death.
Gilbert Ho, Linh Lam, Tony Tran, Jianshe Wei, Makoto Hashimoto   +4 more
doaj   +1 more source

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source