Results 91 to 100 of about 1,269 (186)

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Prothymosinα, as a neuroprotective DAMPs/Alarmins molecule

Folia Pharmacologica Japonica, 2018
Prothymosin alpha (ProTα) has been identified as an anti-necrotic factor from the conditioned medium of primary cultured of rat cortical neurons under the serum-free starving condition. ProTα is released in a non-vesicular manner from neurons or astrocytes by the help of cargo protein S100A13.
Ueda, Hiroshi, Maeda, Shiori
openaire   +3 more sources

Key role of thymic stromal lymphopoietin as a molecular target for biologic treatment of severe asthma

Frontiers in Allergy
Thymic stromal lymphopoietin (TSLP) is an alarmin mainly released by airway epithelial cells injured by many environmental noxious agents such as aeroallergens, respiratory viruses, bacteria, airborne pollutants and cigarette smoking.
Corrado Pelaia, James Melhorn, Giovanni Paoletti, Giovanni Paoletti, Remo Poto, Remo Poto, Angelantonio Maglio, Claudia Crimi, Alessandro Vatrella, Giorgio Walter Canonica, Giorgio Walter Canonica, Girolamo Pelaia   +11 more
doaj   +1 more source

DataSheet_1_Differential Effects of Alarmins on Human and Mouse Basophils.docx

, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Fabrizio Mattei (415284), Adriana R. Gambardella (12641488), Gianni Marone (658976), John T. Schroeder (9516998), Gilda Varricchi (5464439), Valentina Tirelli (547526), Remo Poto (10769413), Giovanna Schiavoni (415280)   +7 more
core   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

The last step to achieve barrier damage control

Frontiers in Immunology
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ...
Ilaria Baglivo, Stefania Colantuono, Arianna Lumaca, Alfredo Papa, Antonio Gasbarrini, Cristiano Caruso   +5 more
doaj   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Alarmins in frozen shoulder: a molecular association between inflammation and pain [PDF]

, 2017
Background: The pathophysiological mechanisms behind proliferation of fibroblasts and deposition of dense collagen matrix in idiopathic frozen shoulder remain unclear.
Neal L. Millar, Hannah, Stephen C., George A.C. Murrell, Kerr, Shauna C., Moeed Akbar, Akbar, Moeed, Millar, Neal L., Jonathon Z.B. Cher, Umberto G. Fazzi, Shauna C. Kerr, Stephen C. Hannah, Murrell, George A.C., Kitson, Susan, Crowe, Lindsay A.N., Michael McLean, Susan Kitson, Fazzi, Umberto G., Emma Garcia-Melchor, McLean, Michael, Cher, Jonathon Z.B., Lindsay A.N. Crowe, Garcia-Melchor, Emma   +21 more
core   +1 more source

Correlation Between Plasma High Mobility Group Protein N1 Level and the Prognosis of Patients with Acute Cerebral Infarction: Preliminary Findings

Neuropsychiatric Disease and Treatment, 2022
Yufeng Lin,1 Kaiyuan Wang,2 Daowen Ji,1 Zhongying Gong,1 Zhiyun Wang1 1Department of Neurology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Department of Anesthesiology ...
Lin Y, Wang K, Ji D, Gong Z, Wang Z
doaj  

Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma

Clinical &Experimental Allergy, EarlyView.
Forced oscillometry technique defined small airways dysfunction as a treatable trait in asthma. Monoclonal antibodies can improve small airways dysfunction, but their effects vary by mechanism of action. ABSTRACT Small airways dysfunction (SAD) is a recognised treatable trait within severe asthma, associated with worse symptom control and increased ...
Robert Greig, Philipp Suter, Rory Chan, Brian Lipworth   +3 more
wiley   +1 more source