Results 91 to 100 of about 10,508 (186)

Environmental Changes and Their Effect on the Airway Microbiome: Implications for Airway Diseases

Allergy, EarlyView.
ABSTRACT Obstructive airway diseases, including asthma and chronic obstructive pulmonary disease (COPD), represent the two major chronic airway inflammatory diseases. In both conditions, the airways are exposed to a variety of microbial and environmental stimuli.
Georgios Rentzos, Evangelia Fouka, Nikolaos Lazarinis, Theo Gülen, Patricia Ramos‐Ramirez, Lauren Flynn, Stelios Loukides, Paraskevi Xepapadaki, Nikolaos G. Papadopoulos, Anders Lindén, Apostolos Bossios   +10 more
wiley   +1 more source

Eosinophil–Epithelial Cell Crosstalk at Mucosal Barriers: From Homeostatic Regulation to Disease Pathogenesis

Cells
Eosinophils are multifunctional granulocytes that reside constitutively within mucosal tissues, where they engage in bidirectional communication with the epithelial cells lining the respiratory and gastrointestinal (GI) tracts.
Janet Lee, Eunsoo Kim
doaj   +1 more source

An Extended Transcriptomic Landscape of Human Skin Mast Cells: Unveiling Lineage‐Specific Noncoding RNA Dynamics in FcεRI Activation

Allergy, EarlyView.
FcεRI cross‐linking triggers widespread transcriptional reprogramming in human skin mast cells (> 5000 genes, > 6400 promoters, and 48 novel mast cell‐enriched lncRNAs). Breast skin and foreskin mast cells share core transcriptional programs but differ selectively in tryptase isoenzymes and IL‐8/IL‐1RA release.
Gürkan Bal, Kristin Franke, Stefan Frischbutter, Shiva Raj Tripathi, Kayoko Yasuzawa, Jordan A. Ramilowski, Michihira Tagami, Takeya Kasukawa, Michiel de Hoon, Jay W. Shin, Piero Carninci, Torsten Zuberbier, Magda Babina   +12 more
wiley   +1 more source

The significance of alarmins ininflammatory rheumatic diseases [PDF]

, 2015
Razumijevanje imunopatogeneze upalnih reumatskih bolesti još uvijek je nepotpuno. Iako je opisana uloga alarmina u različitim upalnim i autoimunim bolestima,klinička ispitivanja iz tog područja još uvijek su rijetka.
BOBEK, Dubravka, JELUŠIĆ, Marija
core   +1 more source

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy
Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
doaj   +1 more source

Alarmins and anti-alarmin biologics in asthma Astımda alarminler ve anti-alarmin biyolojikler

, 2018
Introduction: Alarmins are endogenous, constitutively expressed, chemotactic, and immune activating proteins/peptides that are released as a result of degranulation, cell injury or death, or in response to immune induction.
Görgülü, BEGÜM, Bavbek, Sevim
core   +1 more source

The roles and diversity of alarmins in the mucosae

Alarmins, a group of molecules that function to signal cell stress or death, are a key regulator of the immune response to localized insults. A tissue type often exposed to challenging conditions is the mucosa.
Gaultney, Robert A., Krebs, Philippe, Bessell, Emily, Yeoh, Jeremy, Herbst, Anja   +4 more
core   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Alarmins and Clinical Outcomes After Major Abdominal Surgery—A Prospective Study

, 2017
Purpose: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes.
Jan Máca (3186384), Pavel Ševčík, Peter Sklienka (3186378), Peter Sklienka, Pavel Ševčík (3186375), Michal Holub, Filip Burša (3186372), Michal Burda (3186381), Michal Holub (38791), Jan Máca, Michal Burda, Filip Burša   +11 more
core   +1 more source