Results 91 to 100 of about 9,358 (229)

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes. [PDF]

, 2020
The respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNβ), and IL-21 produced by T cells on the reprogramming of cytotoxic T lymphocytes (CTLs) that cause tissue destruction in celiac disease is poorly understood ...
Wijmenga, Cisca, Wijmenga, Cisca; id_orcid, Weersma, Rinse K, Zorro, Maria Magdalena, Jabri, Bana, Withoff, Sebo, Jonkers, Iris H, Jonkers, Iris H., Weersma, Rinse K.; id_orcid, Wijmenga, Tjitske Nienke (Cisca), Weersma, Rinse K., Aguirre-Gamboa, Raul, Mayassi, Toufic, Hu, Shixian, Li, Yang, Barisani, Donatella, Ciszewski, Cezary   +16 more
core   +1 more source

Chromatin as alarmins in necrotizing enterocolitis

Frontiers in Immunology
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting premature neonates, marked by poorly understood pro-inflammatory signaling cascades. Recent advancements have shed light on a subset of endogenous molecular patterns, termed chromatin-associated molecular patterns (CAMPs), which belong to the broader category of ...
Colleen P. Nofi, Colleen P. Nofi, Colleen P. Nofi, Jose M. Prince, Jose M. Prince, Ping Wang, Ping Wang, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz, Monowar Aziz, Monowar Aziz   +12 more
openaire   +3 more sources

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, EarlyView.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

Advancing precision medicine for asthma by focusing on type 2 cytokines and alarmins [PDF]

Purpose of reviewAsthma is a heterogeneous disease encompassing distinct phenotypes and endotypes. Advances in elucidating the pathogenic role of type 2 (T2) cytokines and epithelial-derived alarmins have profoundly reshaped our understanding of airway ...
Varricchi, Gilda, Portacci, Andrea, Lagnese, Gianluca, Giovannini, Mattia, Poto, Remo, Chan, Rory; id_orcid, Chan, Rory   +6 more
core   +1 more source

Key role of thymic stromal lymphopoietin as a molecular target for biologic treatment of severe asthma

Frontiers in Allergy
Thymic stromal lymphopoietin (TSLP) is an alarmin mainly released by airway epithelial cells injured by many environmental noxious agents such as aeroallergens, respiratory viruses, bacteria, airborne pollutants and cigarette smoking.
Corrado Pelaia, James Melhorn, Giovanni Paoletti, Giovanni Paoletti, Remo Poto, Remo Poto, Angelantonio Maglio, Claudia Crimi, Alessandro Vatrella, Giorgio Walter Canonica, Giorgio Walter Canonica, Girolamo Pelaia   +11 more
doaj   +1 more source

Prothymosinα, as a neuroprotective DAMPs/Alarmins molecule

Folia Pharmacologica Japonica, 2018
Prothymosin alpha (ProTα) has been identified as an anti-necrotic factor from the conditioned medium of primary cultured of rat cortical neurons under the serum-free starving condition. ProTα is released in a non-vesicular manner from neurons or astrocytes by the help of cargo protein S100A13.
Ueda, Hiroshi, Maeda, Shiori
openaire   +3 more sources

Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients

Allergy, EarlyView.
Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.
Taras Lyubchenko, Evgeny Berdyshev, Ryan M. Weight, Olivia Xiao, Neil J. Shah, Alina Markova, Mario E. Lacouture, Jeffrey A. Kern, Elena Goleva, Donald Y. M. Leung   +9 more
wiley   +1 more source

The last step to achieve barrier damage control

Frontiers in Immunology
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ...
Ilaria Baglivo, Stefania Colantuono, Arianna Lumaca, Alfredo Papa, Antonio Gasbarrini, Cristiano Caruso   +5 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source