Results 111 to 120 of about 1,269 (186)

Alarmins and Clinical Outcomes After Major Abdominal Surgery—A Prospective Study

, 2017
Purpose: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes.
Jan Máca (3186384), Pavel Ševčík, Peter Sklienka (3186378), Peter Sklienka, Pavel Ševčík (3186375), Michal Holub, Filip Burša (3186372), Michal Burda (3186381), Michal Holub (38791), Jan Máca, Michal Burda, Filip Burša   +11 more
core   +1 more source

Immunohistochemical Evaluation of TLR‐4, HSP‐70 and Caspase‐3 Expressions in Lesional Areas of Ecthyma Disease

Veterinary Dermatology, EarlyView.
Background: Contagious ecthyma (Orf) is a highly contagious, economically significant disease affecting sheep, goats and wild small ruminants, caused by the resilient Orf virus (ORFV). It produces thick, crusted lesions around the mouth and nostrils, especially in animals aged 3–4 months, sometimes causing near 100% mortality in immunocompromised young
Emine Nur Dincer, Ozlem Ozmen
wiley   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS

, 2019
RationaleEndogenous tissue mediators inducing lung inflammation in the context of ventilator-induced lung injury (VILI) and acute respiratory distress syndrome (ARDS) are ill-defined.ObjectivesTo test whether mitochondrial alarmins are released during ...
Serge Grazioli, Blot, Mathieu, Laure-Anne Pauchard (3156717), Mathieu Blot (4600933), Laure-Anne Pauchard, Pauchard, Laure-Anne, Irène Dunn-Siegrist (178044), Dunn-Siegrist, Irène, Pugin, Jérôme, Jérôme Pugin (3156711), Serge Grazioli (7971410), Grazioli, Serge, Charles, Pierre-Emmanuel, Pierre-Emmanuel Charles (737619), Irène Dunn-Siegrist, Mathieu Blot, Jérôme Pugin, Pierre-Emmanuel Charles   +17 more
core   +1 more source

Anti-alarmins in asthma:targeting the airway epithelium with next-generation biologics

, 2020
Monoclonal antibody therapies have significantly improved treatment outcomes for patients with severe asthma; however, a significant disease burden remains. Available biologic treatments, including anti-immunoglobulin (Ig)E, anti-interleukin (IL)-5, anti-
Sverrild, Asger, Lloyd, Clare M, Menzies-Gow, Andrew N., Porsbjerg, Celeste M., Lloyd, Clare M., Porsbjerg, Celeste M, Bel, Elisabeth H, Bel, Elisabeth H., Menzies-Gow, Andrew N   +8 more
core   +1 more source

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy
Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
doaj   +1 more source