Results 111 to 120 of about 10,508 (186)

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1342-1351, November 2026.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

Evaluating the Impact of Prior Sponge and Lavage Sampling on Gene Expression of Nasal CMA1 and TSLP Collected With Brush

Clinical &Experimental Allergy, EarlyView.
Abigail Davis, Sophie Spicer, Lubnaa Hossenbaccus, Anne K. Ellis   +3 more
wiley   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Benralizumab Inhibits Upper Airway Expression of Thymic Stromal Lymphopoietin in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Marc Duchesne, Jalal Moolji, Adil Adatia, Subhabrata Moitra, Paige Lacy   +5 more
wiley   +1 more source

Time‐of‐Day Variation in Airway Hyperresponsiveness in Asthma: Potential Circadian Mechanisms and Translational Implications

Clinical and Translational Allergy, Volume 16, Issue 11, November 2026.
Graphical abstract Biological time, time‐dependent airway hyperresponsiveness, and clinical translation. The external day–night cycle entrains the central clock in the suprachiasmatic nucleus and peripheral pulmonary clocks, whereas sleep and activity, posture, environmental exposures, and medication timing modify the airway state observed at a given ...
Chang Zhou, Xinyue Hu, Lijuan Zeng, Yi Tang, Chuxian Yi, Guomin Zhang, Sujuan Peng   +6 more
wiley   +1 more source

House Dust Mite Nebulization Drives Alarmin and Complement Activation in a Murine Tracheal Air–Liquid Interface Culture System

Cells
Air–liquid interface (ALI) cultures offer a physiologically relevant in vitro model of the airway epithelium (AE), capable of recapitulating key structural and functional features observed in vivo. In this study, we established and validated a murine ALI
Janti Haj Ahmad, Philip Einwohlt, Mareike Ohms, Doris Wilflingseder, Jörg Köhl   +4 more
doaj   +1 more source

DAMPs, PAMPs and alarmins: all we need to know about danger.

, 2007
: Multicellular animals detect pathogens via a set of receptors that recognize pathogenassociated molecular patterns (PAMPs). However, pathogens are not the only causative agents of tissue and cell damage: trauma is another one.
Marco E Bianchi
core  

Tumors sound the alarmin(s)

, 2008
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed ...
Coffelt, Seth B., Scandurro, Aline B.
core   +1 more source

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue, Qiaolin Li, Chunyan Li, Taoxian Yang, Xian Huang, Feng Yue, Qiuyu Long, Rong Li, Rong Lei, Qingsong Ma, Caimei Hu, Qian Yang, Yongjun Yan, Yuan Liu, QinYong Yan, Mei Yang   +15 more
wiley   +1 more source

The Role of Alarmins in the Pathogenesis of Asthma

Asthma is defined as a chronic respiratory disease, the processes of which are mainly related to the hyperreactivity of the immune system. Airway hyperresponsiveness and remodeling are other hallmarks of asthma that are strongly involved in the ...
Pokwicka, Julia, Kiełbowski, Kajetan, Paulina Plewa, Kajetan Kiełbowski, Bakinowska, Estera, Pawlik, Andrzej, Julia Pokwicka, Andrzej Pawlik, Plewa, Paulina, Estera Bakinowska   +9 more
core   +1 more source