Results 131 to 140 of about 1,269 (186)

Alarmins and More [PDF]

Clinical Therapeutics, 2016
openaire   +2 more sources

Tocilizumab and Dexamethasone Reduce TNF‐α and IL‐33 and Oxidative Stress in Kidney Tissue in Oleic Acid‐Induced ARDS Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Oleic acid causes ARDS‐associated AKI. Tocilizumab and dexamethasone reduces ARDS‐induced kidney injury. The width of the filtration slits increases in kidney injury. Tocilizumab and dexamethasone suppress TNF‐a and IL‐33. ABSTRACT The most common extrapulmonary organ injury in cases of acute respiratory distress syndrome (ARDS) is acute kidney injury (
Huseyin Serkan Erol, Beste Demirci, Mohammad Alhilal, Funda Terzi, Nazli Kelercioglu   +4 more
wiley   +1 more source

House Dust Mite Nebulization Drives Alarmin and Complement Activation in a Murine Tracheal Air–Liquid Interface Culture System

Cells
Air–liquid interface (ALI) cultures offer a physiologically relevant in vitro model of the airway epithelium (AE), capable of recapitulating key structural and functional features observed in vivo. In this study, we established and validated a murine ALI
Janti Haj Ahmad, Philip Einwohlt, Mareike Ohms, Doris Wilflingseder, Jörg Köhl   +4 more
doaj   +1 more source

Modulatory Effect of Alarmins in Immune and Structural Cells: Implication for Asthma Pathogenesis and Clinical Relevance

Background: Asthma is a heterogeneous disease characterized by airway hyperresponsiveness (AHR) and inflammation. Alarmins, including TSLP, IL-33, and IL-25 (IL-17E), are released by epithelial cells in response to environmental triggers and play a ...
Aminah S. Mengash (22951487)
core   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Enhanced Alarmin Secretion Exacerbates Neutrophil Extracellular Trap (NET) Formation in Active Psoriasis: Implication of IL-33 and TSLP in Driving NET Formation, Inflammation and Oxidative Stress in Psoriasis

Antioxidants
Psoriasis is a common inflammatory skin disease with chronic manifestation in which the role of neutrophil extracellular traps (NETs) and alarmins are increasingly recognized as contributors to systemic and cutaneous inflammation.
Vanshika Ojha, Manoj Kumar Tembhre, Vishal Gupta   +2 more
doaj   +1 more source

DAMPs, PAMPs and alarmins: all we need to know about danger.

, 2007
: Multicellular animals detect pathogens via a set of receptors that recognize pathogenassociated molecular patterns (PAMPs). However, pathogens are not the only causative agents of tissue and cell damage: trauma is another one.
Marco E Bianchi
core  

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Gianluca Antonio Franco, Ylenia Marino, Claudia Rifici, Roberta Fusco, Davide di Paola, Salvatore Cuzzocrea, Giuseppe Catone, Cecilia Vullo, Enrico Gugliandolo   +8 more
wiley   +1 more source

High Amounts of S100-Alarmins Confer Antimicrobial Activity on Human Breast Milk Targeting Pathogens Relevant in Neonatal Sepsis

, 2017
Sepsis is a leading cause of perinatal mortality worldwide. Breast milk (BM) feeding is protective against neonatal sepsis, but the molecular mechanisms remain unexplained.
Dorothee Viemann, Christoph Härtel, Beate Fehlhaber, Julia Pagel, Thomas Vogl, Sabine Pirr, Manuela Richter, Johannes Roth   +7 more
core   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source