Results 121 to 130 of about 9,358 (229)

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1353-1363, July 2026.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Suppressing alarmins [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Breakable Organosilica Nanocapsules for the Intracellular Delivery of a Peptide With Promising Anti‐Breast Cancer Activity

ChemistryEurope, Volume 4, Issue 7, July 2026.
Breakable organosilica nanocapsules efficiently deliver the HMGB1‐inhibiting peptide HBP08‐2 intobreast cancer cells. This stimuli‐responsive delivery system overcomes peptide instability, demonstrating high biocompatibility and synergistic cytotoxicity when combined with paclitaxel.
Sara Mathlouthi, Alessandro Ajò, Enrico Mario Alessandro Fassi, Alfredo Cagnotto, Agnese Fragassi, Cristiano Pesce, Mariangela Garofalo, Luisa De Cola, Giovanni Grazioso   +8 more
wiley   +1 more source

The Roles of Innate Immune Cells in Atopic Dermatitis

Journal of Innate Immunity
Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has
Yuke Pan, Youyi Wang, Meinian Xu, Meizhen Zhong, Xiaoming Peng, Kang Zeng, Xiaowen Huang   +6 more
doaj   +1 more source

Caecal Epithelium‐Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Connor P. Lynch, Seona Thompson, Erin‐Claire Pallott, Laura Campbell, Sang Hun Lee, Richard K. Grencis   +5 more
wiley   +1 more source

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury. [PDF]

, 2016
Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators underlying these processes are still largely unknown.
C Sanchez-Bellot (7744448), M Iberl (7744445), EJ Bradbury (7744454), M Puglia (7744442), A Didangelos (7744439), B Roschitzki (7744451)   +5 more
core  

Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability

Frontiers in Cell and Developmental Biology
In Alzheimer’s Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau, may act as alarmins/damage-associated molecular patterns (DAMPs) to stimulate neuroinflammation and cell death.
Gilbert Ho, Linh Lam, Tony Tran, Jianshe Wei, Makoto Hashimoto   +4 more
doaj   +1 more source

Alarmins and More [PDF]

Clinical Therapeutics, 2016
openaire   +2 more sources