Results 121 to 130 of about 1,269 (186)

Advancing precision medicine for asthma by focusing on type 2 cytokines and alarmins

Purpose of reviewAsthma is a heterogeneous disease encompassing distinct phenotypes and endotypes. Advances in elucidating the pathogenic role of type 2 (T2) cytokines and epithelial-derived alarmins have profoundly reshaped our understanding of airway ...
Varricchi, Gilda, Portacci, Andrea, Lagnese, Gianluca, Giovannini, Mattia, Poto, Remo, Chan, Rory; id_orcid, Chan, Rory   +6 more
core   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1196-1205, June 2026.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Integrative Single‐Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1219-1230, June 2026.
Objective Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell–cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

The significance of alarmins ininflammatory rheumatic diseases

, 2015
Razumijevanje imunopatogeneze upalnih reumatskih bolesti još uvijek je nepotpuno. Iako je opisana uloga alarmina u različitim upalnim i autoimunim bolestima,klinička ispitivanja iz tog područja još uvijek su rijetka.
Dubravka BOBEK, BOBEK, Dubravka, JELUŠIĆ, Marija, Marija JELUŠIĆ   +3 more
core  

Skin Tape Stripping: A Non‐Invasive Approach Linking Epidermal Changes and Systemic Inflammation in Atopic Dermatitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
This review positions skin tape stripping as a methodological bridge in atopic dermatitis, linking epidermal molecular profiling with systemic inflammation. Integrated with multi‐omics technologies, STS enables non‐invasive biomarker discovery, disease endotyping, and treatment monitoring, advancing precision medicine for AD. ABSTRACT Atopic dermatitis
Ziyuan Tian, Ke Xue, Yong Cui
wiley   +1 more source

Suppressing alarmins [PDF]

Nature Immunology, 2019
openaire   +2 more sources

The Roles of Innate Immune Cells in Atopic Dermatitis

Journal of Innate Immunity
Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients’ life quality. Summary: AD has
Yuke Pan, Youyi Wang, Meinian Xu, Meizhen Zhong, Xiaoming Peng, Kang Zeng, Xiaowen Huang   +6 more
doaj   +1 more source

Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Background In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease monitoring, and prediction of treatment response ...
Fabio S. Ryser, Tina Mauthe, Catrin Brühlmann, Michael B. Soyka, Urs C. Steiner   +4 more
wiley   +1 more source

Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability

Frontiers in Cell and Developmental Biology
In Alzheimer’s Disease (AD), amyloidogenic proteins (APs), such as β-amyloid (Aβ) and tau, may act as alarmins/damage-associated molecular patterns (DAMPs) to stimulate neuroinflammation and cell death.
Gilbert Ho, Linh Lam, Tony Tran, Jianshe Wei, Makoto Hashimoto   +4 more
doaj   +1 more source