Results 11 to 20 of about 49,195 (244)

Tumor-related HSP70 released after cryo-thermal therapy targeted innate immune initiation in the antitumor immune response

International Journal of Hyperthermia, 2020
Purpose In our previous study, a novel cryo-thermal therapy that could stimulate the maturation of innate immune cells to subsequently activate the CD4+Th1 cell-dominated antitumor response was developed.
Jun Zhu, Yue Lou, Ping Liu, Lisa X. Xu
doaj   +1 more source

Damage-associated molecular patterns and sensing receptors based molecular subtypes in malignant pleural mesothelioma and implications for immunotherapy

Frontiers in Immunology, 2023
ObjectivesMalignant pleural mesothelioma (MPM) is characterized as an incredibly aggressive form of cancer with a dismal diagnosis and a dearth of specific biomarkers and therapeutic options.
Zheng Liu, Rui Wan, Hua Bai, Jie Wang
doaj   +1 more source

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

Redox Report, 2022
Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.Methods Published papers on vitiligo, oxidative stress and DAMPs ...
Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He   +5 more
doaj   +1 more source

Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development

Cells, 2020
Inflammation has been known to be an important driver of fibrogenesis in the liver and onset of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but it can become the main promoter of liver fibrosis.
Simona-Rebeca Ignat, Sorina Dinescu, Anca Hermenean, Marieta Costache   +3 more
doaj   +1 more source

Identification of potential DAMPs released by necroptosis in estrogen-receptor positive breast cancer cells and their effect on macrophage differentiation [PDF]

Exploration of Immunology
Aim: Mutations in key regulators of apoptosis have necessitated exploring the alternative cell death pathways like necroptosis in breast cancer (BC).
Banita Thakur, Rohit Verma, Aditya Dod, Anil K Ram, Yashwant Kumar, Alka Bhatia   +5 more
doaj   +1 more source

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
doaj   +1 more source

Role of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery

Frontiers in Immunology, 2021
Damage-associated molecular patterns (DAMPs) are a group of immunostimulatory molecules, which take part in inflammatory response after tissue injury. Kidney-specific DAMPs include Tamm-Horsfall glycoprotein, crystals, and uromodulin, released by tubular
Pierre-Olivier Ludes, Pierre-Olivier Ludes, Charles de Roquetaillade, Charles de Roquetaillade, Benjamin Glenn Chousterman, Benjamin Glenn Chousterman, Julien Pottecher, Julien Pottecher, Alexandre Mebazaa, Alexandre Mebazaa   +9 more
doaj   +1 more source

Trial watch: dendritic cell vaccination for cancer immunotherapy

OncoImmunology, 2019
Dendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pulsed with a source of tumor-associated antigens (TAAs) in the ...
Jenny Sprooten, Jolien Ceusters, An Coosemans, Patrizia Agostinis, Steven De Vleeschouwer, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg   +8 more
doaj   +1 more source

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells

OncoImmunology, 2019
The major goal of radiotherapy is the induction of tumor cell death. Additionally, radiotherapy can function as in situ cancer vaccination by exposing tumor antigens and providing adjuvants for anti-tumor immune priming. In this regard, the mode of tumor
Julia Krombach, Roman Hennel, Nikko Brix, Michael Orth, Ulrike Schoetz, Anne Ernst, Jessica Schuster, Gabriele Zuchtriegel, Christoph A. Reichel, Susanne Bierschenk, Markus Sperandio, Thomas Vogl, Steffen Unkel, Claus Belka, Kirsten Lauber   +14 more
doaj   +1 more source

A damage-associated molecular patterns-related gene signature for the prediction of prognosis and immune microenvironment in children stage III acute lymphoblastic leukemia

Frontiers in Pediatrics, 2022
BackgroundImmunogenic cell death (ICD)-mediated immune response provides a strong rationale to overcome immune evasion in acute lymphoblastic leukemia (ALL). ICD will produce damage-associated molecular patterns (DAMPs) in tumor microenvironment. However,
Feng Zhao, Feng Zhao, Qiuyu Lin, Xiayu Xiang, Wei Xiang, Wei Xiang   +5 more
doaj   +1 more source