Results 111 to 120 of about 254,410 (141)

Aflibercept-Related Sterile Intraocular Inflammation Outcomes

Ophthalmology Retina, 2019
A recent increase in sterile intraocular inflammation after aflibercept (EYLEA; Regeneron Pharmaceuticals, Inc, Tarrytown, NY) injection was reported to the American Society of Retina Specialists' Research and Safety in Therapeutics Committee. This study describes their clinical characteristics and outcomes.Case series.Sixty-eight eyes of 66 patients ...
Jonathan P. Greenberg, Peter Belin, John Butler, Daniel Feiler, Christian Mueller, Andrew Tye, Steven M. Friedlander, Geoffrey G. Emerson, Philip J. Ferrone   +8 more
openaire   +2 more sources

Sterile Solutions and Peritoneal Inflammation

2006
There is now abundant evidence in both animal and human studies that sterile dialysis solutions result in the alteration of the peritoneal barrier. Mesothelial cells undergo an epithelialto- mesenchymal transition after less than 1 year of dialysis. After more than 6 years of peritoneal dialysis, there is extensive fibrosis and neoangiogenesis in the ...
openaire   +2 more sources

Malondialdehyde epitopes as mediators of sterile inflammation

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017
Enhanced lipid peroxidation occurs during oxidative stress and results in the generation of lipid peroxidation end products such as malondialdehyde (MDA), which can attach to autologous biomolecules, thereby generating neo-self epitopes capable of inducing potentially undesired biological responses. Therefore, the immune system has developed mechanisms
Clara J, Busch, Christoph J, Binder
openaire   +2 more sources

DAMPs and sterile inflammation in drug hepatotoxicity

Hepatology International, 2018
Drug hepatotoxicity is the leading cause of acute liver failure (ALF) in the developed countries. The early diagnosis and treatment are still problematic, and one important reason is the lack of reliable mechanistic biomarkers and therapeutic targets; therefore, searching for new biomarkers and therapeutic targets is urgent. Drug hepatotoxicity induces
Runkuan Yang, Tor Inge Tonnesseen
openaire   +2 more sources

Platelets and HMGB1 in Sterile and Non-sterile Inflammation

2017
Platelets play a critical role in hemostasis, thrombosis, wound healing, and inflammation. We have recently shown that the damage-associated molecular pattern molecule (DAMP) high-mobility group box 1 (HMGB1) derived from platelets plays a critical role in mediating thrombosis and inflammation.
Sebastian Vogel, Meinrad Gawaz
openaire   +1 more source

Chaperones in Sterile Inflammation and Injury

2019
Heat shock proteins (Hsp) are highly conserved proteins and their expression increases in response to stress stimuli for the maintenance of cellular homeostasis. Cellular stress conditions like hypoxia, change in pH, and metabolic changes are typically associated with upregulation of HSP.
Asmita Choudhury, Pranoti Mandrekar
openaire   +1 more source

Sterile neutrinos

Physics Reports, 2021
Basudeb Dasgupta, Joachim Kopp
exaly  

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Annual Review of Pathology: Mechanisms of Disease, 2020
Joel Zindel, Paul Kubes
exaly  

Primordial GATA6 macrophages function as extravascular platelets in sterile injury

Science, 2021
Joel Zindel, Moritz Peiseler, M Hossain
exaly  

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Nature Reviews Immunology, 2019
Tao Gong, Wei Jiang, Rongbin Zhou
exaly