Results 121 to 130 of about 15,199 (265)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

Fertility Beliefs and Menstrual Experiences Among Women Entering Opioid Use Disorder Treatment. [PDF]

open access: yesJ Addict Med
Bello JK   +11 more
europepmc   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

open access: yesAdvanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller   +6 more
wiley   +1 more source

Disability Politics and Reproductive Critique in Gayl Jones’s Corregidora

open access: yesJournal of Integrative and Innovative Humanities
This essay takes a reproductive justice lens, together with the analytical and liberatory insights of intersectional literary and cultural disability studies, to unearth an archive of medical eugenics exercised via non-consensual sterilization in Gayl ...
Theodora Danylevich
doaj  

Desire for reversal after tubal sterilization in the United States, 2006-2023. [PDF]

open access: yesF S Rep
Chiang AY   +4 more
europepmc   +1 more source

Reproductive biology and induced sterility as determinants for genetic control of mosquitoes with the Sterile Insect Technique

open access: yes
Malaria remains an important health issue in sub-Saharan Africa, and new methods to reduce the disease are needed. In this thesis, the use of the Sterile Insect Technique (SIT) against the African malaria vector Anopheles arabiensis was explored. The SIT relies on the releases of large numbers of sterilised males. If the sterile males are successful in
openaire   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

open access: yesAdvanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

open access: yesAdvanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang   +14 more
wiley   +1 more source

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