Results 71 to 80 of about 35,670 (271)
Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]
, 2017 BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de +5 more
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo +7 more
wiley +1 more source
Molecules, 2014 Major rooibos flavonoids—dihydrochalcones, aspalathin and nothofagin, flavones—orientin and vitexin, and a flavonol, rutin, were investigated to determine their influence on the activity of adrenal steroidogenic enzymes, 3β-hydroxysteroid dehydrogenase ...
Lindie Schloms, Amanda C. Swart
doaj +1 more source
Management issues of congenital adrenal hyperplasia during the transition from pediatric to adult care [PDF]
Korean Journal of Pediatrics, 2017 Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into ...
Jin-Ho Choi, Han-Wook Yoo
doaj +1 more source
Intermolecular Enzymatic Encoding of Nucleic Acid, Steroid Complexes: A New Theory on the Chemical Origin of Life Based on Evidence of Structural Symmetry [PDF]
arXiv, 2020 The origin of life is one of the greatest mysteries. The mechanism for the synthesis of DNA is synonymous with the chemical origin of life, and theories have been developed along many lines of reasoning, but resolving all requirements remains a challenge, such as defining an objective path to produce sequences of encoded nucleotides paired as adenine ...
arxiv
Steroid 21-hydroxylase expression and activity in human lymphocytes
Molecular and Cellular Endocrinology, 1997 Steroid 21-hydroxylase encoded by CYP21 is expressed in adrenal cortex. Mutations in CYP21 cause potentially lethal congenital adrenal hyperplasia (CAH). Earlier observations suggested alternative sources of 21-hydroxylase activity, although its genetic source remains unclear.
Veena R. Agarwal +4 more
openaire +3 more sources
Steroid 21-Hydroxylase Mutations and 21-Hydroxylase Messenger Ribonucleic Acid Expression in Human Adrenocortical Tumors1 [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1998 Twenty-one hydroxylase (P450c21) is a key enzyme essential for normal zona glomerulosa and fasciculata function. Recently, 21-hydroxylase deficiency has been implicated in the pathogenesis of adrenocortical tumors. Therefore, we investigated the mutational spectrum of the CYP21B gene and the messenger RNA expression of P450c21 in six aldosterone ...
Beuschlein, Felix +6 more
openaire +4 more sources
Congenital adrenal hyperplasia: Diagnostic advances [PDF]
, 2018 Summary: Congenital adrenal hyperplasia is a group of autosomal recessive disorders resulting from the deficiency of one of the five enzymes required for the synthesis of cortisol in the adrenal cortex.
Biason-Lauber, Anna, Torresani, T.
core +1 more source
Cardiovascular abnormalities and impaired exercise performance in adolescents with congenital adrenal hyperplasia [PDF]
, 2015 Context: Patients with classic Congenital Adrenal Hyperplasia (CAH) are treated with lifelong glucocorticoids (GCS). Cardiovascular (CV) and metabolic effects of such therapy in adolescents have never been quantified.
Alessio, Maria +10 more
core +1 more source
Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research
United European Gastroenterology Journal, EarlyView.ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch +1 more
wiley +1 more source