Results 81 to 90 of about 76,273 (258)

Steroid 21-hydroxylase expression and activity in human lymphocytes

Molecular and Cellular Endocrinology, 1997
Steroid 21-hydroxylase encoded by CYP21 is expressed in adrenal cortex. Mutations in CYP21 cause potentially lethal congenital adrenal hyperplasia (CAH). Earlier observations suggested alternative sources of 21-hydroxylase activity, although its genetic source remains unclear.
Z, Zhou, V R, Agarwal, N, Dixit, P, White, P W, Speiser   +4 more
openaire   +2 more sources

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

Growth characteristics of children with 21-hydroxylase deficiency and the value of steroid hormones in height assessment

BMC Pediatrics
Background Impaired height is a common complication of 21-hydroxylase deficiency (21OHD), yet sensitive monitoring indicators remain limited. This study aims to elucidate growth characteristics and identify effective monitoring parameters for 21OHD ...
Hemeng Chong, Yalei Pi, Yanan Zhang, Yuqian Li, Yutong Xing, Huifeng Zhang   +5 more
doaj   +1 more source

Management issues of congenital adrenal hyperplasia during the transition from pediatric to adult care [PDF]

Korean Journal of Pediatrics, 2017
Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into ...
Jin-Ho Choi, Han-Wook Yoo
doaj   +1 more source

Remission during pregnancy of severe Chronic Hypertension due to 11-ß Hydroxylase Deficiency [PDF]

, 2004
When hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications.
Attard, Gerhardt, Cachia, Mario J.
core  

Variations of Steroid Hormone Metabolites in Serum and Urine in Polycystic Ovary Syndrome after Nafarelin Stimulation: Evidence for an Altered Corticoid Excretion. [PDF]

, 1995
To evaluate the clinical relevance of testing pituitary-ovarian responses in patients suffering from polycystic ovary syndrome (PCOS) with the GnRH agonist nafarelin, a 1.2-mg dose of nafarelin was given intranasally to 19 women with PCOS and 15 healthy ...
A. Lob, Burkhardt Moller, Cornelia H, Dieter Engelhardt, Karl Jacob, Michael M. Weber, Peter Luppa, Rainer Kimmig, Roger, Thomas Strowitzki   +9 more
core   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Novel deletion alleles carrying CYP21A1P/A2 chimeric genes in Brazilian patients with 21-hydroxylase deficiency

BMC Medical Genetics, 2010
Background Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is caused by deletions, large gene conversions or mutations in CYP21A2 gene. The human gene is located at 6p21.3 within a locus containing the genes for putative serine/threonine ...
Guerra-Júnior Gil, Baptista Maria TM, de Lemos-Marini Sofia HV, Petroli Reginaldo J, Lau Ivy F, Paulino Luciana C, de Araújo Marcela, Bernardi Renan D, Soardi Fernanda C, Coeli Fernanda B, de-Mello Maricilda P   +10 more
doaj   +1 more source

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells [PDF]

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Hajime Nawata, Kenji Ohe, Koichi Node, Koichi Oba, Kouichirou Sonoda, Makoto Akashi, Masatoshi Nomura, Ryoichi Takayanagi, Taijiro Okabe, Toshihiko Yanase   +9 more
core   +1 more source

Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]

, 2013
This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade, Banner, Belanger, Beltowski, Benton, Berchtold, Bo Ekstrand, Brunius, Catalfo, Chapman, Chedrese, Chen, Chen, Cherradi, Clark, Coniglio, Conley, Conley, Conley, Cooke, Couet, Coulter, Cue, Davis, De Launoit, Doran, Doran, Dorgan, Dupont, Fink-Gremmels, Furster, Furster, Galarreta, Galia Zamaratskaia, Garrett, Garrett, Gingras, Gingras, Gromadzka-Ostrowska, Haider, Hassan, Havelock, Headon, Hierlihy, Hild-Petito, Hoog, Hu, Joernvall, Kallberg, Kaynard, Keeney, Keeney, Kershaw, Kiessling, Kostic, Kozlowska, Kumar, Labelle-Dumais, Labrie, LaVoie, Leers-Sucheta, Li, Liang, Lorence, Majdic, Martin, Martin Rasmussen, Mason, Mason, Matsunaga, Mcallister, Meadus, Mizrachi, Mode, Mullany, Nakajin, Nakamura, Naville, Nicolau-Solano, Papacleovoulou, Park, Payne, Payne, Payne, Pelletier, Penning, Picon, Rasmussen, Rasmussen, Rasmussen, Rasmussen, Saez, Samuels, Sasano, Sauer, Shapiro, Siiteri, Simard, Simard, Sirianni, Sordoillet, Stayrook, Sun, Suzuki, Takikawa, Takikawa, Tang, The, Tomankova, Tremblay, Val, Von Teichman, Walstra, Wang, Waxman, Waxman, Wong, Yuan, Zamaratskaia, Zamaratskaia, Zhao, Zinedine   +121 more
core   +2 more sources