Results 121 to 130 of about 2,979 (148)

Extraadrenal Steroid 21-Hydroxylase Activity in a Woman with Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency*

The Journal of Clinical Endocrinology & Metabolism, 1983
The 21-hydroxylation of plasma progesterone (P) has been demonstrated in pregnant, nonpregnant, and adrenalectomized women and in men. The fractional conversion of plasma progesterone to deoxycorticosterone (DOC), [rho]P-DOC BU, among those subjects was 0.009 +/- 0.001 (mean +/- SEM, n = 32).
C A, Winkel, M L, Casey, R J, Worley, J D, Madden, P C, MacDonald   +4 more
openaire   +2 more sources

Urinary steroid excretion in 17α-hydroxylase deficiency

Journal of Steroid Biochemistry, 1978
Abstract Urinary steroids from a patient with 17α-hydroxylase deficiency syndrome have been identified. The steroids were obtained by enzymatic hydrolysis of urine, Amberlite XAD-2 extraction and Sephadex LH-20 column chromatography. Following preparation of volatile derivatives, the steroids were separated and estimated by gas chromatography on open-
J W, Honour, J, Tourniaire, E G, Biglieri, C H, Shackleton   +3 more
openaire   +2 more sources

Steroid 16α‐Hydroxylase from Human Fetal Liver; Inhibition by Steroids

Acta Obstetricia et Gynecologica Scandinavica, 1980
The 16α‐hydroxylase system in fetal liver which used dehydroepiandrosterone (DHA) or pregnenolone as substrate, was apparently inhibited by various endogenous and synthetic steroids: DHA, pregnenolone, their sulfates, androstenediol, androstenetriol, estrone, estradiol‐17β, ethynylestradiol and chlormadinone‐acetate.
Y, Sano, H, Shibusawa, N, Yoshida, K, Sekiba, S, Okinaga, K, Arai   +5 more
openaire   +2 more sources

Disorders of the Aldosterone Synthase and Steroid 11β-Hydroxylase Deficiencies

Hormone Research in Paediatrics, 1999
The most potent corticosteroids are 11β-hydroxylated compounds. In humans, two cytochrome P450 isoenzymes with 11β-hydroxylase activity, catalysing the biosynthesis of cortisol and aldosterone, are present in the adrenal cortex. CYP11B1, the gene encoding 11β-hydroxylase (P450c11), is expressed on high levels in the zona fasciculata and is regulated by
Peter, M, Dubuis, Jean-Michel Marie Maurice, Sippell, WG   +2 more
openaire   +3 more sources

The steroid 16α-hydroxylase system in mammalian liver

Steroids, 1966
Abstract The 16α-hydroxylation of testosterone and androst-4-ene-3, 17-dione (2) and of estradiol-17β (3) takes place in the presence of a microsomal fraction of rat liver. The rate of 16α-hydroxylation of 3β-hydroxyandrost-5-en-17-one (DHA) by liver slices is significantly higher for male than for female adult rats (4).
W L, Heinrichs, H H, Feder, A, Colás
openaire   +2 more sources

Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases

Journal of Steroid Biochemistry and Molecular Biology, 2018
In the last decades, sulfonated steroids evolved from inactive metabolites intended for excretion to highly relevant compounds involved in many physiological processes. Investigations of the impact of sulfonated steroids on the steroid hormone biosynthesis revealed that, on the one hand, these can serve as substrate for steroidogenic cytochromes P450 ...
J, Neunzig, R, Bernhardt
exaly   +3 more sources

Steroid 11β-Hydroxylase Deficiency

2001
Inherited defects in cortisol biosynthesis are collectively termed congenital adrenal hyperplasia [reviewed in (1)]. Steroid 21-hydroxylase deficiency is, by far, the most common of these defects; it is reviewed elsewhere in this volume. This chapter reviews a related disease, steroid 11β-hydroxylase deficiency [reviewed in greater detail in (2)].
openaire   +1 more source

Heterogeneity of the Bovine Adrenal Steroid 21-Hydroxylase

Endocrine Research, 1989
The results presented indicate that purified cytochrome P-45021 which migrated upon SDS gel electrophoresis essentially as a single band, is further separable into different species by ion-exchange chromatography. The P-450 eluted from the CM-Sephadex column at different points along the buffer concentration gradient, exhibited significant differences ...
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Intracellular distribution and properties of steroid 11β-hydroxylase and steroid 18-hydroxylase in rat adrenal

Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1964
Y, NAKAMURA, B, TAMAOKI
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Regulation of steroid hydroxylase gene expression and steroid hormone biosynthesis

Biochemical Society Transactions, 1990
M R, Waterman, J, Lund, R, Ahlgren, D, Wu, E R, Simpson   +4 more
openaire   +2 more sources