Results 11 to 20 of about 509,885 (240)
Induction and Repression of Steroid Hydroxylases and Dehydrogenases in Mixed Culture Fermentations
Journal of General Microbiology, 1969 SUMMARY: Some factors affecting induction and repression of steroid-transforming enzymes were studied in single and mixed cultures of Arthrobacter simplex, Nocardia restrictus and Streptomyces roseochromogenes.
B. K. Lee +3 more
openalex +2 more sources
Food Science &Nutrition, Volume 11, Issue 1, Page 191-203, January 2023., 2023 The IOP‐A has a hypolipidemic effect, which may be due to its ability to regulate the expression of CYP7A1 and SREBP‐1c, as well as to correct an imbalance in the structure of the intestinal microflora. Abstract The purpose of this study was to observe the effect of Inonotus obliquus polysaccharide (IOP) on blood lipids and its regulation on the ...
Fengyuan Lin +7 more
wiley +1 more source
Metabolites of an Epac-selective cAMP analog induce cortisol synthesis by adrenocortical cells through a cAMP-independent pathway. [PDF]
PLoS ONE, 2009 Adrenal zona fasciculata (AZF) cells express a cAMP-activated guanine nucleotide exchange protein (Epac2) that may function in ACTH-stimulated cortisol synthesis.
Judith A Enyeart, John J Enyeart
doaj +1 more source
The FEBS Journal, 2018 Bacterial cytochrome P450 (CYP) enzymes are involved in the hydroxylation of various endogenous substrates while using a heme molecule as a cofactor.
Bikash Dangi +8 more
semanticscholar +1 more source
mBio, 2018 Side chain-containing steroids are ubiquitous constituents of biological membranes that are persistent to biodegradation. Aerobic, steroid-degrading bacteria employ oxygenases for isoprenoid side chain and tetracyclic steran ring cleavage. In contrast, a
Christian Jacoby +10 more
doaj +1 more source
Applied and Environmental Microbiology, 2018 Steroidal drugs are widely used for anti-inflammation, anti-tumor action, endocrine regulation, and fertility management, among other uses. The two main starting materials for the industrial synthesis of steroid drugs are phytosterol and diosgenin.
Hao-Hao Liu +7 more
semanticscholar +1 more source
Biotransformation of steroids by entomopathogenic strains of Isaria farinosa
Microbial Cell Factories, 2018 Background Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult.
Ewa Kozłowska +9 more
doaj +1 more source
Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. [PDF]
Proceedings of the National Academy of Sciences, 1992 A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It was identified as CYP11B2, which was previously postulated to be a pseudogene or a less active gene closely related to CYP11B1, the gene encoding steroid 11 beta-hydroxylase (P-45011 beta) [Mornet, E., Dupont, J., Vitek, A. & White, P. C.
Yasuhiro Mitsuuchi +9 more
openaire +3 more sources
BMC Genomics, 2010 Background Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function.
Parente Thiago +7 more
doaj +1 more source
Haplotypes of the steroid 21-hydroxylase gene region encoding mild steroid 21-hydroxylase deficiency. [PDF]
Proceedings of the National Academy of Sciences, 1991 Haplotypes of the complement 4 (C4) and steroid 21-hydroxylase [21-OHase; steroid hydrogen-donor: oxygen oxidoreductase (21-hydroxylating), EC 1.14.99.10] repeated gene complex were studied in nine families with at least one member affected with a mild form of 21-OHase deficiency.
Jan Gustafsson +3 more
openaire +3 more sources