Results 21 to 30 of about 5,963 (192)

Identification of a Baeyer-Villiger monooxygenase sequence motif [PDF]

, 2002
Baeyer-Villiger monooxygenases (BVMOs) form a distinct class of flavoproteins that catalyze the insertion of an oxygen atom in a C-C bond using dioxygen and NAD(P)H.
Berkel, Willem J.H. van, Fraaije, MW, Janssen, DB, Kamerbeek, Nanne M., Kamerbeek, NM, van Berkel, WJH   +5 more
core   +2 more sources

Enzymatic functionalization of carbon-hydrogen bonds [PDF]

, 2011
The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds continues to progress at a rapid pace due to the significant economic and environmental benefits of these transformations over traditional synthetic methods.
Arnold, Frances H., Coelho, Pedro S., Lewis, Jared C.   +2 more
core   +1 more source

Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations [PDF]

, 1990
A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine.
Boidin, M.P. (Marinus Pieter), Erdmann, W. (Wilhelm), Stuurman, A. (Arie)   +2 more
core   +1 more source

The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells [PDF]

, 2013
Indiana University-Purdue University Indianapolis (IUPUI)17-β estradiol (E2) exerts protective effects in hypoxia-induced pulmonary hypertension (HPH) via endothelial cell estrogen receptor (ER)-dependent mechanisms. However, the effects of hypoxia on ER
Selej, Mona M.A.
core   +2 more sources

Sex steroids, carcinogenesis, and cancer progression [PDF]

, 2004
The relationship between sex steroids and cancer has been studied for more than a century. Using an original intact cell analysis, we investigated sex steroid metabolism in a panel of human cancer cell lines, either hormone responsive or unresponsive ...
Agostara, B., BRONTE, Giuseppe, CAMPISI, Ildegarda, CARRUBA, Giuseppe, CASTAGNETTA, Luigi, COCCIADIFERRO, Letizia, Granata, O., Polito, L., RIZZO, Sergio, SAETTA, Annalisa   +9 more
core   +1 more source

Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent [PDF]

, 2014
The soil actinomycete Kutzneria sp. 744 produces a class of highly decorated hexadepsipeptides, which represent a new chemical scaffold that has both antimicrobial and antifungal properties.
Adams P. D., Bosello M., Broberg A., Catherine L. Drennan, Chocklett S. W., Christopher T. Walsh, Dauter Z., Emsley P., Entsch B., Franceschini S., Franceschini S., Frederick R. E., Frederick R. E., Fujimori D. G., Gatti D. L., Ge L., Goldman P. J., Heemstra J. R., Heemstra J. R., Husain M., Jeremy W. Setser, Jiang W., John R. Heemstra, Krissinel E., Krissinel E. E., Krueger S. K., Lennon B. W., Mayfield J. A., McCoy A. J., Meneely K. M., Meneely K. M., Mirza I. A., Moriarty N. W., Morin A., Murshudov G., Neumann C. S., Neumann C. S., Newman D. J., Olucha J., Otwinowski Z., Palfey B. A., Pettersen E. F., Plattner H. J., Pohanka A., Pohlmann V., Robbel L., Robinson R., Robinson R. M., Rodríguez-Otero J., Romero E., Røhr A. K., Sheng D., Shirey C., Sievers F., Stein N., Strieker M., Thariath A. M. A., Vagin A. A., van Berkel W. J. H., Walsh C. T., Zheng Y. J., Zolova O. E.   +61 more
core   +1 more source

Phylogenomic analysis of integral diiron membrane histidine motif-containing enzymes in ciliates provides insights into their function and evolutionary relationships [PDF]

, 2017
The Integral Membrane Histidine Motif-containing Enzymes (IMHME) are a class of binuclear non-heme iron proteins widely distributed among prokaryotes and eukaryotes.
Cid, Nicolás Gonzalo, Elguero, María Eugenia, Montes, María Guadalupe, Nudel, Berta Clara, Nusblat, Alejandro David, Sánchez Granel, María Luz   +5 more
core   +1 more source

The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer [PDF]

, 2014
Peer reviewedPublisher ...
Alnabulsi, Ayham, Blihoghe, Daniela, Brown, Gordon T, Cash, Beatriz Giminez, Johansson, Petronella, Murray, Graeme I   +5 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source