Results 11 to 20 of about 3,096 (185)

8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.

Am J Physiol Endocrinol Metab, 2011
The regulation of cortisol synthesis and the expression of genes coding for steroidogenic proteins by 8-substituted cAMP and 8-substituted adenine derivatives were studied in bovine adrenal zona fasciculata (AZF) cells.
Enyeart JA, Liu H, Enyeart JJ.
europepmc   +2 more sources

Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion [PDF]

, 2022
Understanding the structural basis of the selectivity of steroid hydroxylation requires detailed structural and functional investigations on various steroid hydroxylases with different selectivities, such as the bacterial cytochrome P450 enzymes. Here,
Hutter, Michael, Kiss, Flora, Lancaster, C. Roy D., Carius, Yvonne, Bernhardt, Rita   +4 more
core   +1 more source

Multiplicity of 3-Ketosteroid-9α-Hydroxylase Enzymes in Rhodococcus rhodochrous DSM43269 for Specific Degradation of Different Classes of Steroids [PDF]

, 2011
The well-known large catabolic potential of rhodococci is greatly facilitated by an impressive gene multiplicity. This study reports on the multiplicity of kshA, encoding the oxygenase component of 3-ketosteroid 9α-hydroxylase, a key enzyme in steroid ...
Petrusma, Mirjan, Mirjan Petrusma, Hessels, Gerda,, Geize, Robert van der,, van der Geize, Robert, Dijkhuizen, Lubbert,, Dijkhuizen, Lubbert, Gerda Hessels, Robert van der Geize, Hessels, Gerda, Petrusma, Mirjan,, Dijkhuizen, Lubbert; id_orcid, Lubbert Dijkhuizen   +12 more
core   +1 more source

Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis

Revista Brasileira de Reumatologia, 2012
Os glicocorticoides (GC) são prescritos por praticamente todas as especialidades médicas, e cerca de 0,5% da população geral do Reino Unido utiliza esses medicamentos.
Rosa Maria Rodrigues Pereira, Jozélio Freire de Carvalho, Ana Patrícia Paula, Cristiano Zerbini, Diogo S. Domiciano, Helenice Gonçalves, Jaime S. Danowski, João F. Marques Neto, Laura M. C. Mendonça, Mailze C. Bezerra, Maria Teresa Terreri, Marta Imamura, Pedro Weingrill, Perola G. Plapler, Sebastião Radominski, Tatiana Tourinho, Vera L. Szejnfeld, Nathalia C. Andrada   +17 more
doaj   +1 more source

Characterization and regulation of sex-specific mouse steroid hydroxylase genes

, 1990
We characterized the genes of the male-specific mouse steroid 16α-hydroxylase (C-P-45016α) and the female-specific mouse steroid 15α-hydroxylase (P-45015α) within two distinct gene families. In spite of the high structural identities within each family,
Masahiko Negishi, Barbara Burkhart, Raija Lindberg, Takeshi Ichikawa, Takao Itakura, Hidefumi Yoshioka, Garry Wong   +6 more
core   +1 more source

Inactivation of rat liver microsomal steroid hydroxylations by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine: evidence for selectivity among steroid-inducible cytochrome P450IIIA forms

, 1990
Various 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) cause mechanism-based inactivation of cytochrome P-450 (P-450) via destruction of the heme prosthetic group.
I. McGilvray, D. S. Riddick, G. S. Marks
core   +1 more source

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. [PDF]

Proceedings of the National Academy of Sciences, 1992
A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It was identified as CYP11B2, which was previously postulated to be a pseudogene or a less active gene closely related to CYP11B1, the gene encoding steroid 11 beta-hydroxylase (P-45011 beta) [Mornet, E., Dupont, J., Vitek, A. & White, P. C.
T, Kawamoto, Y, Mitsuuchi, K, Toda, Y, Yokoyama, K, Miyahara, S, Miura, T, Ohnishi, Y, Ichikawa, K, Nakao, H, Imura   +9 more
openaire   +2 more sources

From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance

Advanced Science, EarlyView.
Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu, Ke Wang, Huachuan Tuo, Jiankun Li, Liping Xu, Chang‐Jun Liu, Mingyue Gou   +6 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Steroid Hormone Vitamin D [PDF]

, 2018
Understanding of vitamin D physiology is important because about half of the population is being diagnosed with deficiency and treated with supplements. Clinical guidelines were developed based on observational studies showing an association between low ...
Tintut, Yin, Demer, Linda L, Yin Tintut, Jeffrey J. Hsu, Linda L. Demer, Hsu, Jeffrey J   +5 more
core   +1 more source