Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2019 Steroid sulfatase (STS) plays an important role in the regulation of steroid hormones. Metabolism of steroid hormones in zebrafish has been investigated, but the action of steroid sulfatase remains unknown. In this study, a zebrafish sts was cloned, expressed, purified, and characterized in comparison with the orthologous human enzyme. Enzymatic assays
Katsuhisa Kurogi +6 more
europepmc +5 more sources
X-linked ichthyosis associated with psychosis and behavioral abnormalities: a case report [PDF]
Journal of Medical Case Reports, 2017 Background X-linked ichthyosis is a dermatological condition caused by deficiency for the enzyme steroid sulfatase. Previously, X-linked ichthyosis/steroid sulfatase deficiency has been associated with developmental and neurological phenotypes.
Alrifai, Muhammed T +7 more
core +4 more sources
Novel Point Mutations in the Steroid Sulfatase Gene in Patients with X-Linked Ichthyosis: Transfection Analysis Using the Mutated Genes [PDF]
, 2000 X-linked ichthyosis is caused by steroid sulfatase deficiency which results from abnormalities in its coding gene. The majority of X-linked ichthyosis patients (≈90%) have complete or partial deletions of the steroid sulfatase gene.
Iwatsuki, Keiji +3 more
core +3 more sources
Development of steroid sulfatase inhibitors [PDF]
Molecular and Cellular Endocrinology, 2011 Hydrolysis of biologically inactive steroid sulfates to unconjugated steroids by steroid sulfatase (STS) is strongly implicated in rendering estrogenic stimulation to hormone-dependent cancers such as those of the breast. Considerable progress has been made in the past two decades with regard to the discovery, design and development of STS inhibitors ...
Woo, L. W. L. +2 more
openaire +5 more sources
Expression of Steroid Sulfatase during Embryogenesis* [PDF]
Endocrinology, 1997 Neurosteroids are steroids that are synthesized de novo in the brain from cholesterol and, in general, mediate their effects through ion-gated channel receptors such as gamma-aminobutyric acidA (GABA[A]) and N-methyl-D-aspartate receptors rather than through classical nuclear steroid hormone receptors.
Nathalie A. Compagnone +4 more
openaire +4 more sources
Steroid sulfatase:a pivotal player in estrogen synthesis and metabolism [PDF]
, 2011 International audienceSteroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone
Potter, Barry V. L. +2 more
core +5 more sources
Somatic and Germinal Mosaicism for the Steroid Sulfatase Gene Deletion in a Steroid Sulfatase Deficiency Carrier [PDF]
Journal of Investigative Dermatology, 2002 Steroid sulfatase deficiency results in X-linked ichthyosis, an inborn error of metabolism in which the principal molecular defect is the complete deletion of the steroid sulfatase gene and flanking markers. Mosaicism for the steroid sulfatase gene has not yet been reported in X-linked ichthyosis.
Sergio A. Cuevas-Covarrubias +6 more
openaire +4 more sources
Steroid Sulfatase Deficiency [PDF]
Pediatric Research, 1977 Placental steroid sulfatase deficiency is a genetic disorder only recently reported in the medical literature. Most documented cases of placental sulfatase deficiency have been marked by delay in onset of labor, lack of cervical dilatation, and relative refractoriness of oxytocic agents and amniotomy. We have studied the placenta, cultured fibroblasts,
Richard L. Stevens +4 more
openaire +3 more sources
Characterization of iodothyronine sulfatase activities in human and rat liver and placenta [PDF]
, 2002 In conditions associated with high serum iodothyronine sulfate concentrations, e.g. during fetal development, desulfation of these conjugates may be important in the regulation of thyroid hormone homeostasis. However, little is known
Coughtrie, M.W. +6 more
core +2 more sources
Development and validation of a fast gas chromatography combustion isotope ratio mass spectrometry method for the detection of epiandrosterone sulfate in urine [PDF]
, 2020 In doping control, to confirm the exogenous origin of exogenously administered anabolic androgenic steroids (AAS), a gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) analysis is performed.
De Wilde, Laurie +3 more
core +1 more source