Results 1 to 10 of about 3,508 (215)

Estrogen Formation and Inactivation Following TBI: What we Know and Where we Could go

Frontiers in Endocrinology, 2020
Traumatic brain injury (TBI) is responsible for various neuronal and cognitive deficits as well as psychosocial dysfunction. Characterized by damage inducing neuroinflammation, this response can cause an acute secondary injury that leads to widespread ...
Kelli A. Duncan
doaj   +1 more source

Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells.

PLoS ONE, 2016
Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Here we show that at a physiological concentration (1 μM), DHEAS induces the phosphorylation of the kinase Erk1/2 and of the
Dimitrios Papadopoulos, Raimund Dietze, Mazen Shihan, Ulrike Kirch, Georgios Scheiner-Bobis   +4 more
doaj   +1 more source

Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

Molecules, 2010
Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both ...
Donald Poirier, Florian Delagoutte, Marie Bérubé   +2 more
doaj   +1 more source

Simultaneous quantification of cholesterol sulfate, androgen sulfates, and progestagen sulfates in human serum by LC-MS/MS[S]

Journal of Lipid Research, 2015
Steroids are primarily present in human fluids in their sulfated forms. Profiling of these compounds is important from both diagnostic and physiological points of view.
Alberto Sánchez-Guijo, Vinzenz Oji, Michaela F. Hartmann, Heiko Traupe, Stefan A. Wudy   +4 more
doaj   +1 more source

Kallmann syndrome and ichthyosis: a case of contiguous gene deletion syndrome

Endocrinology, Diabetes & Metabolism Case Reports, 2017
Kallmann syndrome is a genetically heterogeneous form of hypogonadotropic hypogonadism caused by gonadotropin-releasing hormone deficiency and characterized by anosmia or hyposmia due to hypoplasia of the olfactory bulbs; osteoporosis and metabolic ...
Irene Berges-Raso, Olga Giménez-Palop, Elisabeth Gabau, Ismael Capel, Assumpta Caixàs, Mercedes Rigla   +5 more
doaj   +1 more source

A novel nonsense mutation in the STS gene in a Pakistani family with X-linked recessive ichthyosis: including a very rare case of two homozygous female patients

BMC Medical Genetics, 2020
Background X-linked ichthyosis (XLI; OMIM# 308100) is a recessive keratinization disorder characterized by the presence of dark brown, polygonal, adherent scales on different parts of the body surface.
Sibtain Afzal, Khushnooda Ramzan, Sajjad Ullah, Salma M. Wakil, Arshad Jamal, Sulman Basit, Ahmed Bilal Waqar   +6 more
doaj   +1 more source

Molecular interaction between steroid sulfatases and formylglycine generating enzyme: A computational study with multiple mutations [PDF]

, 2022
Kanchan Kumari, Rashmi Rekha Samal, Umakanta Subudhi   +2 more
openalex   +1 more source

Distinguishing ichthyoses by protein profiling.

PLoS ONE, 2013
To explore the usefulness of protein profiling for characterization of ichthyoses, we here determined the profile of human epidermal stratum corneum by shotgun proteomics.
Robert H Rice, Katie M Bradshaw, Blythe P Durbin-Johnson, David M Rocke, Richard A Eigenheer, Brett S Phinney, Matthias Schmuth, Robert Gruber   +7 more
doaj   +1 more source

Steroid sulfatase inhibitors and sulfated C19 steroids for proteotoxicity-related diseases: a patent spotlight. [PDF]

Pharm Pat Anal, 2023
Al-Horani RA.
europepmc   +1 more source

Both N-terminal and C-terminal regions of steroid sulfatase are important for enzyme activity [PDF]

, 2006
Teruo Sugawara, Eiji Nomura, Nobuhiko Hoshi   +2 more
openalex   +1 more source