Results 111 to 120 of about 452,915 (259)

Naisen rasvakudoksen endokrinologiaa - steroidihormonimetabolian yhteys rintasyöpään [PDF]

, 2016
Rasva­kudos on eli­mis­tömme suu­rin endok­rii­ninen elin. Hormo­naa­linen sää­tely vai­kuttaa rasva­ku­doksen toi­mintaan ja kerty­miseen, jo­ka on eri­laista nai­silla ja mie­hillä se­kä ke­hon eri osissa. Rasva­kudos on myös merkit­tävä ste­roi­di­hor­
Mikkola, Tomi, Savolainen-Peltonen, Hanna, Tikkanen, Matti J.   +2 more
core  

Pain management challenges in a patient with mucopolysaccharidosis IVA

Clinical Case Reports, Volume 12, Issue 8, August 2024.
Key Clinical Message It is important to consider all potential pain management modalities including alternative treatment on managing complex pain presentations. Acupuncture is a treatment modality that may result in reduction of pain in patients with significant medical comorbidities due to MPS IVA.
Marcus Gurgius, Sarah Donoghue, Robyn A. Wallace   +2 more
wiley   +1 more source

A biological guide to glycosaminoglycans: current perspectives and pending questions

The FEBS Journal, Volume 291, Issue 15, Page 3331-3366, August 2024.
Mammalian glycosaminoglycans, except hyaluronan, are sulfated polysaccharides that are covalently attached to core proteins to form proteoglycans. They contribute to the organization of the extracellular matrix and are displayed at the cell surface where they regulate the availability and activity of cytokines and growth factors and cell signaling ...
Sylvie Ricard‐Blum, Romain R. Vivès, Liliana Schaefer, Martin Götte, Rosetta Merline, Alberto Passi, Paraskevi Heldin, Ana Magalhães, Celso A. Reis, Spyros S. Skandalis, Nikos K. Karamanos, Serge Perez, Dragana Nikitovic   +12 more
wiley   +1 more source

Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment

Journal of Peptide Science, Volume 30, Issue 7, July 2024.
The development of highly affine, selective peptides and small molecules in recent years has allowed peptide drugs (PDCs) and small molecule–drug conjugates (SMDCs) to increasingly compete with antibody–drug conjugates (ADCs). This review summarises and describes integrin‐addressing PDCs and SMDCs, while highlighting points of great interest.
Jannik Paulus, Norbert Sewald
wiley   +1 more source

Effect of tibolone on breast cancer cell proliferation in postmenopausal ER+ patients: Results from STEM trial [PDF]

, 2007
Purpose: Tibolone is a selective tissue estrogenic activity regulator, approved for the treatment of vasomotor symptoms in postmenopausal women. We have done an exploratory, double-blind, randomized, placebo-controlled pilot trial to investigate the ...
Dowsett, Mitch, Foidart, Jean-Michel, Gomez, Juan V.M. Planellas, Hageluken, Cornelius C. M., Kubista, Ernst, Manikhas, Alexey G., Nechushkin, Michail, Pohlodek, Kamil, Semiglazov, Victor F., Serreyn, Rudolphe, Singer, Christian F.   +10 more
core   +2 more sources

Kallmann syndrome and ichthyosis: a case of contiguous gene deletion syndrome

Endocrinology, Diabetes & Metabolism Case Reports, 2017
Kallmann syndrome is a genetically heterogeneous form of hypogonadotropic hypogonadism caused by gonadotropin-releasing hormone deficiency and characterized by anosmia or hyposmia due to hypoplasia of the olfactory bulbs; osteoporosis and metabolic ...
Irene Berges-Raso, Olga Giménez-Palop, Elisabeth Gabau, Ismael Capel, Assumpta Caixàs, Mercedes Rigla   +5 more
doaj   +1 more source

Fate of conjugated natural and synthetic steroid estrogens in crude sewage and activated sludge batch studies [PDF]

, 2009
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Environmental Science & Technology, copyright © American Chemical Society after peer review.
Alcock R. E., Baronti C., Bitton G., Brown J. B., Bursch W., Desbrow C., Dray J., D’Ascenzo G., Fotsis T., Gentilli A., Gomes R. L., Gomes R. L., Gomes R. L., Gomes R. L., Guengerich F. P., Isobe T., Johnson A. C., Johnson A. C., Jones O. A. H., Koh Y. K. K., Komori K., Panter G. H., Ranney R. E., Reddy S., Routledge E. J., Schlüsener M. P., Solé M., Tang P. W., Ternes T. A., Ternes T. A., Vandenheuvel F. A., Yamamoto A., Zhang H.   +32 more
core   +1 more source

High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency[S]

Journal of Lipid Research, 2015
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of ...
Alberto Sánchez-Guijo, Vinzenz Oji, Michaela F. Hartmann, Hans-Christian Schuppe, Heiko Traupe, Stefan A. Wudy   +5 more
doaj  

Distinguishing ichthyoses by protein profiling.

PLoS ONE, 2013
To explore the usefulness of protein profiling for characterization of ichthyoses, we here determined the profile of human epidermal stratum corneum by shotgun proteomics.
Robert H Rice, Katie M Bradshaw, Blythe P Durbin-Johnson, David M Rocke, Richard A Eigenheer, Brett S Phinney, Matthias Schmuth, Robert Gruber   +7 more
doaj   +1 more source

A novel nonsense mutation in the STS gene in a Pakistani family with X-linked recessive ichthyosis: including a very rare case of two homozygous female patients

BMC Medical Genetics, 2020
Background X-linked ichthyosis (XLI; OMIM# 308100) is a recessive keratinization disorder characterized by the presence of dark brown, polygonal, adherent scales on different parts of the body surface.
Sibtain Afzal, Khushnooda Ramzan, Sajjad Ullah, Salma M. Wakil, Arshad Jamal, Sulman Basit, Ahmed Bilal Waqar   +6 more
doaj   +1 more source