Results 151 to 160 of about 3,508 (215)

Sulfation pathways in times of change. [PDF]

Essays Biochem
Mueller JW, Fietz D, Dias IHK.
europepmc   +1 more source

Sulfation pathways in the maintenance of functional beta-cell mass and implications for diabetes. [PDF]

Essays Biochem
Mueller JW, Thomas P, Dalgaard LT, da Silva Xavier G.   +3 more
europepmc   +1 more source

From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights. [PDF]

Iran J Med Sci
Tamadon A, Zare A, Mahdipour M, Salehpour A, Mussin NM, Mussina AA, Aringazina RA, Duisenova A, Zhilisbayeva KR, Kurmanalina MA, Fu C.   +10 more
europepmc   +1 more source

Assessing endocrine resistance: monitoring circulating ESR1 mutations in Irosustat-treated ER positive breast cancer. [PDF]

Breast Cancer Res Treat
Page K, Martinson LJ, Hastings RK, Acheampong E, Wadsley MK, Allsopp RC, Luo JL, Coombes RC, Shaw JA, Palmieri C.   +9 more
europepmc   +1 more source

Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.

Psychoneuroendocrinology, 2012
Trent S, Dennehy A, Richardson H, Ojarikre OA, Burgoyne PS, Humby T, Davies W.   +6 more
europepmc   +1 more source

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Steroid sulfatase inhibitors: the current landscape

Expert Opinion on Therapeutic Patents, 2021
Introduction: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids. Both the deficiency and the over-expression of STS are associated with the pathophysiology of certain diseases.
Hanan S. Anbar, Zahraa Isa, Jana J. Elounais, Mariam A. Jameel, Joudi H. Zib, Aya M. Samer, Aya F. Jawad, Mohammed I. El-Gamal   +7 more
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Steroid sulfatase inhibitors

Expert Opinion on Therapeutic Patents, 2003
AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Peter, Nussbaumer, Andreas, Billich
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Steroid sulfatase inhibitors

Expert Opinion on Therapeutic Patents, 1999
Steroid sulfatase catalyses the hydrolysis of sulfated steroids to their corresponding hydroxylated forms. Since oestrogens and androgens can be synthesised intracellularly from the abundant circulating sulfated steroids, steroid sulfatase inhibitors should prove to be valuable therapeutic agents for the treatment of hormono-dependent diseases ...
Donald Poirier, Liviu C Ciobanu, René Maltais   +2 more
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Steroid derivatives as inhibitors of steroid sulfatase

The Journal of Steroid Biochemistry and Molecular Biology, 2013
Sulfated steroids function as a storage reservoir of biologically active steroid hormones. The sulfated steroids themselves are biologically inactive and only become active in vivo when they are converted into their desulfated (unconjugated) form by the enzyme steroid sulfatase (STS).
Yaser A, Mostafa, Scott D, Taylor
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Dual Aromatase−Steroid Sulfatase Inhibitors

Journal of Medicinal Chemistry, 2007
By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. The best DASIs in vitro (JEG-3 cells) are 5, (IC50(aromatase) = 0.82 nM; IC50(sulfatase) = 39 nM), and 14, (IC50(aromatase) = 0.77 nM; IC50(sulfatase) = 590 nM).
Woo, L.W.L., Bubert, C., Sutcliffe, O.B., Smith, A., Chander, S.K., Mahon, M.F., Purohit, A., Reed, M.J., Potter, B.V.L.   +8 more
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