Results 171 to 180 of about 3,508 (215)

Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase

Biochemical and Biophysical Research Communications, 1988
Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
D A, Robertson, C, Freeman, P V, Nelson, C P, Morris, J J, Hopwood   +4 more
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[Steroid sulfatase inhibitor].

Nihon rinsho. Japanese journal of clinical medicine, 2010
More than 60 percents of breast cancers occur in post menopausal women and most of their initial stages are hormone dependent. For the treatment of estrogen dependent breast tumors, mainly two treatment tools are available, one is selective estrogen receptor modulator (SERM), and the other is aromatase inhibitor (AI).
Taisuke, Nakata, Hiroyuki, Ishida, Yukimasa, Shiotsu   +2 more
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Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors

The Journal of Steroid Biochemistry and Molecular Biology, 1996
About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several
P K, Li, S, Milano, L, Kluth, M E, Rhodes   +3 more
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Human placental steroid sulfatase: Purification and properties

Journal of Steroid Biochemistry, 1983
Steroid sulfatase is recovered quantitatively from the 105,000 g h supernatant of human placental microsomes extracted with Triton X-100. The solubilized enzyme has been purified using conventional techniques. Throughout the purification procedure, steroid sulfatase appears to be heterogeneous as evidenced by certain, but not all, criteria.
H, Noël, L, Plante, G, Bleau, A, Chapdelaine, K D, Roberts   +4 more
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Inhibition of steroid sulfatase activity by danazol

Acta Obstetricia et Gynecologica Scandinavica, 1984
Abstract. The hydrolysis of dehydroepiandrosterone sulfate (DHAS) by human liver cells in culture and the hydrolysis of and formation of estradiol‐17β (E2) from estrone sulfate PIS) by human breast tumor preparations in vitro were studies in the presence and absence of danazol.
K, Carlström, A, Döberl, A, Pousette, G, Rannevik, N, Wilking   +4 more
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Boronic acids as inhibitors of steroid sulfatase

Bioorganic & Medicinal Chemistry, 2006
Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate. STS is considered to be a potential target for the development of therapeutics for the treatment of steroid-dependent cancers.
Vanessa, Ahmed, Yong, Liu, Cassandra, Silvestro, Scott D, Taylor   +3 more
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Distribution of Steroid Sulfatase in Human Tissues

The Journal of Clinical Endocrinology & Metabolism, 1965
Distribution of steroid sulfatase in human tissues was determined by incubating whole homogenates of placenta, hydatidiform mole, fetal membranes, ovarian cortex, corpus luteum, arrhenoblastoma, myometrium, leiomyomata, endometrium, liver, kidney, striated muscle, adipose tissue and skin with 4-14C-dehydroisoandrosterone sulfate.
J C, WARREN, A P, FRENCH
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Elevated steroid sulfatase expression in breast cancers

The Journal of Steroid Biochemistry and Molecular Biology, 2000
In situ estrogen synthesis makes an important contribution to the high estrogen concentration found in breast cancer tissues. Steroid sulfatase which hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate may be involved.
T, Utsumi, N, Yoshimura, S, Takeuchi, M, Maruta, K, Maeda, N, Harada   +5 more
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Steroid Sulfatase Activity in Human Fetal Membranes

The Journal of Clinical Endocrinology & Metabolism, 1977
The human fetal membranes appear to play an important role in transport and metabolism of steroids, in the maintenance of pregnancy and perhaps in the metabolic processes leading to the initiation of parturition. Therefore, steroid sulfatase activity of human fetal membranes was studied and found to reside in the chorion laeve, with the amnion totally ...
N F, Gant, L, Milewich, M E, Calvert, P C, MacDonald   +3 more
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Rat testis steroid sulfatase: 2. Kinetic study

Steroids, 1969
Abstract The cleavage of pregnenolone sulfate (Km = 0.3 × 10−5 M/L) by rat testis tissue was demonstrated to be more facile than the cleavages of 5-androsten-17β-ol-3β-sulfate (Km = 0.5 × 10−5 M/L), 17β-estradiol-3-sulfate (Km = 1.2 × 10−5 M/L), estrone sulfate (Km = 2 × 10−5 M/L), and 17β-acetyl-5-androstene-3β-sulfate (Km = 3 × 10−5 M/L ...
A D, Notation, F, Ungar
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