Transgenic overexpression of steroid sulfatase alleviates cholestasis [PDF]
Liver Research, 2017 Background and Aim: Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exogenous molecules.
Mengxi Jiang +4 more
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Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors [PDF]
Journal of Ovarian Research, 2021 Background Ovarian cancer is usually diagnosed at an advanced stage due to its early asymptomatic course and late-stage non-specific symptoms. This highlights the importance of researching the molecular mechanisms involved in ovarian carcinogenesis as ...
Argelia Calvillo-Robledo +10 more
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The important roles of steroid sulfatase and sulfotransferases in gynecological diseases [PDF]
Frontiers in Pharmacology, 2016 Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Tea eLanisnik Rizner
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Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes [PDF]
Scientific Reports, 2021 Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.
Hyoung-Seok Baek +4 more
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A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals. [PDF]
Arch Womens Ment Health, 2021 Thippeswamy H, Davies W.
europepmc +3 more sources
High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency[S] [PDF]
Journal of Lipid Research, 2015 Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of ...
Alberto Sánchez-Guijo +5 more
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2-Difluoromethoxy-Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition. [PDF]
ChemMedChem, 2022 Dohle W +8 more
europepmc +3 more sources
Inhibition steroid sulfatase suppresses androgen signaling and improves response to enzalutamide
European Urology Open Science, 2020 A. Gao +7 more
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Breast Cancer: Basic and Clinical Research, 2009 It is known that the steroid sulfatase (STS) and the estrogen sulfotransferase (EST1E1) are commonly expressed in human breast carcinomas. STS and EST1E1 combined action could maintain the equilibrium between sulfated (inactive) and unconjugated (active)
D. Poisson Paré +7 more
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Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice. [PDF]
J Biol Chem, 2019 Feng Y +11 more
europepmc +3 more sources