Results 11 to 20 of about 452,017 (283)

Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. [PDF]

Sci Rep, 2021
Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.
Baek HS, Kwon TU, Shin S, Kwon YJ, Chun YJ.   +4 more
europepmc   +5 more sources

IRIS study: a phase II study of the steroid sulfatase inhibitor Irosustat when added to an aromatase inhibitor in ER-positive breast cancer patients [PDF]

Breast Cancer Res Treat, 2017
Purpose: Irosustat is a first-generation, orally active, irreversible steroid sulfatase inhibitor. We performed a multicentre, open label phase II trial of the addition of Irosustat to a first-line aromatase inhibitor (AI) in patients with advanced BC to
A Billich, A Marinković-Ilsen, A Sharma, Adrian Lim, B Malini, C Bjerregaard-Olesen, C Palmieri, Carlo Palmieri, Chris Holcombe, Emma Hudson, F Pizzagalli, Fouzia Guestini, GN Hortobagyi, H Ruder, Hanna Nicholas, Hironobu Sasano, I Shin, J Adams, J Baselga, J O’Hara, KM Elliott, KT Morris, Larry Hayward, Laura Kenny, M Maggiolini, MJ Sikora, MJ Sikora, N Chanplakorn, NC Turner, P Wang, R Hobkirk, R Poulin, R. Charles Coombes, RC Coombes, RC Stein, RJ Santen, Rob C. Stein, S Dauvois, SA Fuqua, SA Fuqua, Sacha Howell, Sadie Reed, SJ Stanway, SJ Stanway, Sophie Barrett, SR Johnston, T Suzuki, T Utsumi, T Utsumi, Xinxue Liu   +49 more
core   +5 more sources

A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals. [PDF]

Arch Womens Ment Health, 2021
Postpartum mood disorders develop shortly after childbirth in a significant proportion of women. These conditions are associated with a range of symptoms including abnormally high or low mood, irritability, cognitive disorganisation, disrupted sleep ...
Thippeswamy H, Davies W.
europepmc   +4 more sources

Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors. [PDF]

J Ovarian Res, 2021
Background Ovarian cancer is usually diagnosed at an advanced stage due to its early asymptomatic course and late-stage non-specific symptoms. This highlights the importance of researching the molecular mechanisms involved in ovarian carcinogenesis as ...
Calvillo-Robledo A, Pedernera E, Morales-Vásquez F, Pérez-Montiel D, Gómora MJ, Almaraz MÁ, de Alba Graue PG, Rendón E, López-Basave HN, Quintanar-Stephano A, Méndez C.   +10 more
europepmc   +3 more sources

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases [PDF]

Nature Communications, 2021
Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
Mercedes M. Pérez-Jiménez, José M. Monje-Moreno, Ana María Brokate-Llanos, Mónica Venegas-Calerón, Alicia Sánchez-García, Paula Sansigre, Amador Valladares, Sara Esteban-García, Irene Suárez-Pereira, Javier Vitorica, José Julián Ríos, Marta Artal-Sanz, Ángel M. Carrión, Manuel J. Muñoz   +13 more
doaj   +3 more sources

Development of benzofuran-derived sulfamates as dual aromatase-steroid sulfatase inhibitors (DASIs): design, synthesis and biological evaluation. [PDF]

RSC Med Chem
Resistance of oestrogen receptor-positive (ER+) breast cancer, the most prevalent type of breast cancer accounting for ∼70% of all cases, to current therapies necessitates the study of alternative strategies. One promising strategy is the multi-targeting
Eissa AG, Gozzi F, Aloqab O, Parrish CE, Mohamed N, Shiali I, Al-Baldawi H, Foster PA, Simons C.   +8 more
europepmc   +3 more sources

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases. [PDF]

Front Pharmacol, 2016
Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women.
Rižner TL.
europepmc   +3 more sources

C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors. [PDF]

ACS Omega, 2018
Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are ...
Ganeshapillai D, Woo LWL, Thomas MP, Purohit A, Potter BVL.   +4 more
europepmc   +3 more sources

Transgenic overexpression of steroid sulfatase alleviates cholestasis [PDF]

Liver Research, 2017
Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exogenous molecules. STS catalyzes the hydrolysis of steroid sulfates to form hydroxysteroids.
Mengxi Jiang, Songrong Ren, Meishu Xu, Kyle W. Selcer, Wen Xie   +4 more
europepmc   +5 more sources

X‐linked ichthyosis presenting with cryptorchidism for orchidopexy: A rare anesthetic encounter and case report [PDF]

Clinical Case Reports, Volume 12, Issue 8, August 2024.
Key Clinical Message Cutaneous scaling and associated clinical syndrome displayed in X‐linked ichthyosis mandates multidisciplinary care. Patient with ichthyosis confronts a numerous challenge to an anesthesiologist and demands a rigorous management.
Sunil Bhatta, Sukriti Pandit, Pratik Chaudhary, Naresh Thapa Chhetri   +3 more
wiley   +3 more sources