Results 221 to 230 of about 452,915 (259)

Distribution of Steroid Sulfatase in Human Tissues

The Journal of Clinical Endocrinology & Metabolism, 1965
Distribution of steroid sulfatase in human tissues was determined by incubating whole homogenates of placenta, hydatidiform mole, fetal membranes, ovarian cortex, corpus luteum, arrhenoblastoma, myometrium, leiomyomata, endometrium, liver, kidney, striated muscle, adipose tissue and skin with 4-14C-dehydroisoandrosterone sulfate.
Alfred P. French, James C. Warren
openaire   +3 more sources

Boronic acids as inhibitors of steroid sulfatase

Bioorganic & Medicinal Chemistry, 2006
Steroid sulfatase (STS) catalyzes the hydrolysis of steroidal sulfates such as estrone sulfate (ES1) to the corresponding steroids and inorganic sulfate. STS is considered to be a potential target for the development of therapeutics for the treatment of steroid-dependent cancers.
Scott D. Taylor, Yong Liu, Cassandra Silvestro, Vanessa Ahmed   +3 more
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Steroid Sulfatase Activity in Human Leukocytes

Gynecologic and Obstetric Investigation, 1994
To study steroid sulfatase activity in women in the field of obstetrics and gynecology, especially to differentiate carrier women with steroid sulfatase deficiency (recessive X-linked ichthyosis, RXLI) from normal women, steroid sulfatase activity was assayed in peripheral blood leukocytes from normal nonpregnant women, pregnant women, patients with ...
Mori N, Miyakawa I, Kawano Y, Taniyama K
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Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase

Journal of Medicinal Chemistry, 1998
Synthetic routes to potent steroidal and nonsteroidal sulfamate-based active site-directed inhibitors of the enzyme steroid sulfatase, a topical target in the treatment of postmenopausal women with hormone-dependent breast cancer, are described. Novel compounds were examined for estrone sulfatase (E1-STS) inhibition in intact MCF-7 breast cancer cells ...
L. W. Lawrence Woo, Hatem Hejaz, Atul Purohit, Nicola M. Howarth, Barry V. L. Potter, Michael J. Reed   +5 more
openaire   +3 more sources

Frequency of steroid sulfatase deficiency in Hiroshima

Pediatrics International, 2007
A retrospective survey was performed between 1983 and 1995 to determine the frequency of steroid sulfatase (STS) deficiency in Hiroshima. Males with ichthyosis were diagnosed enzymatically. During 1979-95 in Hiroshima Prefecture, 275,943 males were born and 28 had STS deficiency. The observed frequency of STS deficiency was 1 per 9855 males. Therefore,
Takahiko Matsumoto, Shin-Ichiro Nishimura, Nobuo Sakura, Minoru Ohsaki   +3 more
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Characterization of rat and human steroid sulfatases

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
Rat and human steroid sulfatases were purified from liver and placenta, respectively, by the same procedure. The rat and human enzymes were solubilized with Triton X-100, and purified by immunoaffinity chromatography with a monoclonal antibody showing high binding activities to both the enzymes.
Tomio Kotani, Tsutomu Oinuma, Hisayuki Matsuo, Eizo Aikawa, Naoto Minamino, Sachiya Ohtaki, Jun-ichi Kawano   +6 more
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Steroidal oxathiazine inhibitors of estrone sulfatase

Steroids, 2003
The presence of estrone sulfatase in breast tumors and the high levels of circulating estrone sulfate may contribute the major portion of estrogen synthesized locally in breast tissues through conversion of estrone sulfate to estrone by the enzyme. Using inhibitors of estrone sulfatase for the treatment of estrogen-dependent (estrogen receptor positive,
Kazuhiko Shigeno, Masato Tanabe, Nurulain T. Zaveri, Wan Ru Chao, Richard H. Peters, Barbara Sato   +5 more
openaire   +3 more sources

Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferases

Chemico-Biological Interactions, 1998
Net sulfation of 4-methylumbelliferone in intact hepatocytes is regulated, in part, by substrate cycling between sulfotransferases (SULT) and arylsulfatases (ARS). Thus, ARS have the potential to influence rates of net sulfate conjugation of a variety of compounds in intact cells via interaction with SULT.
Bernard B. Allan, Michael W.H. Coughtrie, Frederick C. Kauffman, Ann Burchell, Sheila Sharp   +4 more
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Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase

Biochemical and Biophysical Research Communications, 1988
Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
John J. Hopwood, Daniel A. Robertson, Craig Freeman, C. Phillip Morris, Paul V. Nelson   +4 more
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Antisulfatase, Osteogenic, and Anticancer Activities of Steroid Sulfatase Inhibitor EO-33 in Mice.

Journal of Medicinal Chemistry, 2019
Steroid sulfatase (STS) is a key enzyme involved in the biosynthesis of estrogens from inactive sulfated steroids. After we reported EO-33 as a potent in vitro STS inhibitor without undesirable estrogenic activity and with osteogenic properties, we are ...
D. Poirier, J. Roy, R. Maltais, D. Ayan
semanticscholar   +1 more source