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Synthesis and Stability of Steroid Sulfatase in Fibroblasts from Multiple Sulfatase Deficiency
Biological Chemistry Hoppe-Seyler, 1988Multiple sulfatase deficiency is a lysosomal storage disorder, which can be divided into group I with severe and group II with moderate deficiencies in sulfatases. Antibodies raised against steroid sulfatase purified from human placenta were used to follow the biosynthesis and stability of this enzyme in multiple sulfatase-deficiency fibroblasts ...
Jon T. Conary +2 more
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Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors
The Journal of Steroid Biochemistry and Molecular Biology, 1996About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several
Pui-Kai Li +3 more
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First Dual Aromatase-Steroid Sulfatase Inhibitors
Journal of Medicinal Chemistry, 2003Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important additional source of tumor estrogen, and blockade of both enzymes should provide a more effective endocrine therapy.
Woo, L.W.L. +7 more
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Human placental steroid sulfatase: Purification and properties
Journal of Steroid Biochemistry, 1983Steroid sulfatase is recovered quantitatively from the 105,000 g h supernatant of human placental microsomes extracted with Triton X-100. The solubilized enzyme has been purified using conventional techniques. Throughout the purification procedure, steroid sulfatase appears to be heterogeneous as evidenced by certain, but not all, criteria.
Henri Noël +4 more
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Yakhak Hoeji, 2018
— The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treat-ment of postmenopausal women with breast cancer.
Ji‐Hyun Park, E. Ma
semanticscholar +1 more source
— The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treat-ment of postmenopausal women with breast cancer.
Ji‐Hyun Park, E. Ma
semanticscholar +1 more source
Steroid Sulfatase Activity in Human Fetal Membranes
The Journal of Clinical Endocrinology & Metabolism, 1977The human fetal membranes appear to play an important role in transport and metabolism of steroids, in the maintenance of pregnancy and perhaps in the metabolic processes leading to the initiation of parturition. Therefore, steroid sulfatase activity of human fetal membranes was studied and found to reside in the chorion laeve, with the amnion totally ...
Leon Milewich +3 more
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Elevated steroid sulfatase expression in breast cancers
The Journal of Steroid Biochemistry and Molecular Biology, 2000In situ estrogen synthesis makes an important contribution to the high estrogen concentration found in breast cancer tissues. Steroid sulfatase which hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate may be involved.
Nobuhiro Harada +5 more
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Aromatase and steroid sulfatase from human placenta.
Methods in Enzymology, 2023Debashis Ghosh
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Steroid sulfatase and estrogen sulfotransferase in human carcinomas
Molecular and Cellular Endocrinology, 2011Estrogens are closely involved in the development of hormone-dependent carcinomas. Estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase (STS), while estrone is inversely inactivated into estrone sulfate by estrogen sulfotransferase (EST).
Yasuhiro Nakamura +4 more
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