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Regional assignment of the gene locus for steroid sulfatase
Human Genetics, 1980The gene locus for steroid sulfatase, deficiency of which causes X-linked ichthyosis, is assigned to Xp11 leads to Xpter by analysis of 24 man-Chinese hamster somatic cell hybrids. High steroid sulfatase activity in a hybrid clone having retained only part of Xq is explained by demonstration of an additional late-replicating human X chromosome.
H. H. Ropers +4 more
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Associated Steroid-Sulfatase Deficiency
1989Occasionally, X-linked recessive ichthyosis is accompanied by other symptoms such as mental retardation, short stature, epilepsy, and severe hypogonadism. Until very recently, these cases were mostly classified under the diagnostic label of the so-called Rud syndrome [16] (see Sect.
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Steroid 21-sulfatase activity in human placenta
Journal of Steroid Biochemistry, 1983Intravenously administered [3H]-deoxycorticosterone sulfate is not metabolized by way of deoxycorticosterone in men or non-pregnant women. Thus, it can be implied that steroid 21-sulfatase is not active in human tissues. On the other hand, evidence has accrued that deoxycorticosterone sulfate is hydrolyzed in human placenta.
Paul C. MacDonald +3 more
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Testicular steroid sulfatase in a cryptorchid rat strain
Journal of Steroid Biochemistry, 1989Steroid sulfatase (STS) activity was studied in scrotal and abdominal testes from genetically unilateral cryptorchid rats. Specific STS activity was significantly increased in microsomes from abdominal and scrotal testes of the cryptorchid animals as compared to that of control ones.
Georges Pointis +3 more
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Analysis for Localization of Steroid Sulfatase in Human Tissues
2005Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances. STS has been demonstrated in human breast cancer tissues and is considered to be involved in intratumoral estrogen production.
Yasuhiro Miki +5 more
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Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles
Canadian Journal of Biochemistry and Cell Biology, 1985This review discusses the biological roles of steroid sulfotransferase enzymes (ST's) and steroid sulfate sulfohydrolases (sulfatases) mainly in mammalian tissues. In addition, some consideration is given to certain characteristics of these enzymes and, where possible, to their biological control. A considerable number of ST's of varying specificities,
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Steroid Sulfatase in the Human Placenta
The Journal of Clinical Endocrinology & Metabolism, 1962Charles E. Timberlake, James C. Warren
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