Results 51 to 60 of about 3,508 (215)

Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified

Journal of Investigative Medicine High Impact Case Reports, 2020
To characterize the expression of steroidogenic enzymes implicated in the development of ovarian steroid cell tumors, not otherwise specified (SCT-NOS). We present 4 ovarian SCT-NOS evaluated by immunohistochemical staining of steroidogenic enzymes as an
Evana Valenzuela Scheker MD, Amita Kathuria MD, Ashwini Esnakula MD, Hironobu Sasano MD, Yuto Yamazaki MD, Sergei Tevosian PhD, Richard J. Auchus MD, PhD, Hans K. Ghayee DO, Gauri Dhir MD   +8 more
doaj   +1 more source

Sulfatases: Catalytic Mechanism, Substrate Preferences, and Carbohydrate‐Based Inhibitor Design

Israel Journal of Chemistry, Volume 65, Issue 12, December 2025.
Sulfatases are a class of enzymes that can cleave sulfates from heparan sulfate and modulate many of their biological activities. In this review, following a general introduction on sulfatase, their enzymatic mechanism and substrate scope are discussed.
Morgan Mayieka, Julius Benicky, Radoslav Goldman, Xuefei Huang   +3 more
wiley   +1 more source

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

Functional Ecology, Volume 39, Issue 11, Page 3050-3060, November 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

Assessment of Annona muricata Phytochemicals as 17β‐HSD1 Inhibitors through Molecular Docking, Dynamics Simulation, DFT, and ADMET Analyses

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Breast cancer remains a leading cause of female mortality, largely sustained by local oestrogen production. The enzyme 17β‐hydroxysteroid dehydrogenase type 1 (17β‐HSD1) is an enzyme involved in the oestrogen biosynthesis pathway, particularly in the conversion of estrone to estradiol, and is overexpressed in conditions such as breast cancer ...
Emad Rashad Sindi, Md Jannatul Islam Polash, Guilherme Bastos Alves, Imren Bayil, Samson Olusegun Afolabi, Hanan M. Alharbi, Alaa A. Khojah, Jonas Ivan Nobre Oliveira, Aamal A. Al‐Mutairi, Magdi E. A. Zaki   +9 more
wiley   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

X‐linked ichthyosis presenting with cryptorchidism for orchidopexy: A rare anesthetic encounter and case report

Clinical Case Reports
Key Clinical Message Cutaneous scaling and associated clinical syndrome displayed in X‐linked ichthyosis mandates multidisciplinary care. Patient with ichthyosis confronts a numerous challenge to an anesthesiologist and demands a rigorous management.
Sunil Bhatta, Sukriti Pandit, Pratik Chaudhary, Naresh Thapa Chhetri   +3 more
doaj   +1 more source

The significance of microbiota in New Zealand seaweed aquaculture

New Zealand Journal of Marine and Freshwater Research, Volume 59, Issue 3, Page 509-536, September 2025.
ABSTRACT Seaweed‐associated microbes are the metabolic heavy lifters in the symbiotic relationship between the seaweed microbiome and their host macroalgae. In exchange for fixed carbon and an exclusive niche habitat offered by the host, the microbial consort performs a litany of crucial metabolic functions including vitamin production, nitrogen ...
Olivia C. Macrae, Chelsea J. Vickers
wiley   +1 more source

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, Volume 157, Issue 4, Page 599-613, 15 August 2025.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies

Applied Sciences, 2022
C-Ring oxidized estrone acetate derivatives as antiproliferative agents were prepared and tested against five cancer cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Catarina Canário, Mariana Matias, Vanessa Brito, Patrícia Pires, Adriana O. Santos, Amílcar Falcão, Samuel Silvestre, Gilberto Alves   +7 more
doaj   +1 more source