Results 1 to 10 of about 437,081 (334)

Neuroactive Steroids: Receptor Interactions and Responses

Frontiers in Neurology, 2017
Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs).
Kald Beshir Tuem, Tesfay Mehari Atey
exaly   +3 more sources

Steroid Sulfation in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku, Martin Hill, Lucie Kolatorova, Eva Kubala Havrdova, Radmila Kancheva   +4 more
doaj   +1 more source

A case of unusual presentation of stridor by laryngeal pemphigus

Journal of Medical and Scientific Research, 2021
Pemphigus is an uncommon condition of mucosal and dermatological manifestations. Isolated laryngeal pemphigus without skin lesions is extremely rare. Supraglottic lesions are common in laryngeal pemphigus.
Subrahmanyam C, Dasari P, Rao IS, Mohammad K, Voggu A   +4 more
doaj   +1 more source

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue

Journal of Translational Medicine, 2023
Background Causative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Julia Oakley, Martin Hill, Adam Giess, Mélanie Tanguy, Greg Elgar   +4 more
doaj   +1 more source

Cholangiocarcinoma Presenting after Eight Years of Treatment of IgG4-Related Autoimmune Pancreatitis with Steroids

Case Reports in Gastroenterology, 2021
Autoimmune pancreatitis (AIP) is characterized by pancreatic manifestations of IgG4-related disease. Malignancies in patients with AIP have been reported, but carcinoma of the bile duct is extremely rare.
Hiroharu Shinozaki, Yuuichi Sasakura, Satoshi Shinozaki, Toshiaki Terauchi, Junichi Matsui, Kenji Kobayashi, Alan Kawarai Lefor, Yoshiro Ogata   +7 more
doaj   +1 more source

A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays

Frontiers in Endocrinology, 2021
The nuclear receptor pregnane X receptor (PXR) is a ligand-dependent transcription factor that regulates genes involved in xenobiotic metabolism in mammals. Many studies suggest that PXR may play a similar role in fish. The interaction of human PXR (hPXR)
Nicolas Creusot, Clémentine Garoche, Marina Grimaldi, Abdelhay Boulahtouf, Barbara Chiavarina, William Bourguet, Patrick Balaguer   +6 more
doaj   +1 more source

Comparisons of Serum Progesterone and Progestagen Concentrations in Normal and Abnormal Bottlenose Dolphin (Tursiops truncatus) Pregnancies

Frontiers in Marine Science, 2021
Although previous studies have described progesterone profiles during pregnancy in the bottlenose dolphin (Tursiops truncatus), most of these focused on normal pregnancy (NORM) or compared NORM to only one or two abnormal pregnancy types, such as ...
Todd R. Robeck, Karen J. Steinman, Celeste B. Parry, Forrest M. Gomez, Eric D. Jensen   +4 more
doaj   +1 more source

Predictors of steroid non-response and new approaches in severe alcoholic hepatitis [PDF]

Clinical and Molecular Hepatology, 2020
Severe alcoholic hepatitis (SAH) remains a disease with high mortality. Steroid is the main stay and has been shown to give modest 28-day survival benefit in carefully selected patients, but no 90-day survival benefit.
Shiv Kumar Sarin, Shvetank Sharma
doaj   +1 more source

Management of Immune-Related Adverse Events in Patients With Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
With proven efficacy of the use of immunotherapy in almost all stages of NSCLC, immunotherapy toxicity has become a very important topic that requires immediate recognition and management. The diagnosis of toxicities associated with immunotherapy in lung
Michael Burke, Sawsan Rashdan
doaj   +1 more source

The Antiviral Effect of Novel Steroidal Derivatives on Flaviviruses

Frontiers in Microbiology, 2021
Flaviviruses are the major emerging arthropod-borne pathogens globally. However, there is still no practical anti-flavivirus approach. Therefore, existing and emerging flaviviruses desperately need active broad-spectrum drugs.
Luping Zhang, Luping Zhang, Luping Zhang, Dengyuan Zhou, Dengyuan Zhou, Dengyuan Zhou, Qiuyan Li, Qiuyan Li, Qiuyan Li, Shuo Zhu, Shuo Zhu, Shuo Zhu, Muhammad Imran, Muhammad Imran, Muhammad Imran, Hongyu Duan, Hongyu Duan, Hongyu Duan, Shengbo Cao, Shengbo Cao, Shengbo Cao, Shaoyong Ke, Jing Ye, Jing Ye, Jing Ye   +24 more
doaj   +1 more source