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Steroid Sulfation in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku, Martin Hill, Lucie Kolatorova, Eva Kubala Havrdova, Radmila Kancheva   +4 more
doaj   +1 more source

Clinical Characteristics and Effects of Steroid Therapy in Children with Acute Cerebellar Ataxia [PDF]

Annals of Child Neurology, 2021
Purpose Acute cerebellar ataxia (ACA) is characterized by unsteady gait and instability of the trunk, and is caused by secondary autoimmune responses to infection or vaccination in healthy children.
Joo Young Lee, Ja Un Moon, Da Hye Yoon, Ji Yoon Han, In Goo Lee   +4 more
doaj   +1 more source

Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue

Journal of Translational Medicine, 2023
Background Causative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Julia Oakley, Martin Hill, Adam Giess, Mélanie Tanguy, Greg Elgar   +4 more
doaj   +1 more source

Successful use of steroids in the management of two patients of diarrhea-associated adult hemolytic uremic syndrome

Journal of Applied Hematology, 2021
Diarrhea-associated hemolytic uremic syndrome (HUS) occurs sporadically in the community. It is well known in the pediatric age group but also occurs in the adults, albeit with lower frequency.
Ajay Jaryal, Sanjay Vikrant, Balbir Singh Verma, Sachin Gautam, Dinesh Kumar   +4 more
doaj   +1 more source

Efficacy and Safety of Rituximab in Immunobullous Diseases: A Retrospective Study from a Tertiary Care Centre of Nepal [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Rituximab is effective and safe treatment of immunobullous disorders. There are variations in doses of drugs used in different studies and uncertainties on when to use it along with use of adjuvant therapies. Efficacy and safety of this
Sudip Parajuli, Jyoti Vidhan, Dinesh Binod Pokhrel, Upama Paudel   +3 more
doaj   +1 more source

Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids

Frontiers in Molecular Biosciences, 2021
Glucocorticoids are a class of steroid hormones secreted from the adrenal glands. The strong anti-inflammatory effects make it be one of the most popular and versatile drugs available to treat chronic inflammatory diseases.
Yun Hao, Yun Hao, Feiyi Zhang, Feiyi Zhang, Shanshan Mo, Jinming Zhao, Jinming Zhao, Xiangdong Wang, Xiangdong Wang, Yan Zhao, Yan Zhao, Luo Zhang, Luo Zhang, Luo Zhang   +13 more
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A novel approach to rapid induction of remission in primary membranous nephropathy

Терапевтический архив, 2021
Aim. То evaluate the effectiveness of a novel multi-targeted treatment approach including rituximab (RTX), cyclophosphamide (CPH) and steroids (S) to the induction of remission in patients with primary membranous nephropathy (PMN) compared to standard ...
Vladimir A. Dobronravov, Olga B. Bystrova, Zinaida Sh. Kochoyan, Evgeniya N. Fomicheva   +3 more
doaj   +1 more source

Effect of corticosteroid administration on cardiac arrest: a systematic review and network meta-analysis of the timing of administration [PDF]

Clinical and Experimental Emergency Medicine, 2022
Corticosteroids may have a beneficial effect on the outcome of cardiac arrest (CA); however, it is not known whether the timing of corticosteroid use affects the outcome.
Youngchan Pyo, Tae Nyoung Chung
doaj   +1 more source

Occurrence and reproductive roles of hormones in seminal plasma

Basic and Clinical Andrology, 2017
Résumé Les spermatozoïdes ne représentent que 2 à 25% du liquide séminal, le reste étant constitué par le plasma séminal. Le plasma séminal est un cocktail de composés organiques et non organiques comprenant des hormones qui font office de source de ...
Jana Vitku, Lucie Kolatorova, Richard Hampl   +2 more
doaj   +1 more source

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

Frontiers in Cell and Developmental Biology, 2021
The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors ...
Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Isabel Viola Wagner, Frederik Börgel, Dirk Schepmann, Andreas Schüring, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wünsch, Verena Nordhoff, Timo Strünker, Timo Strünker, Christoph Brenker   +15 more
doaj   +1 more source