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Steroids and Steroid-Sparing Agents in Asthma
New England Journal of Medicine, 1988Asthma is a disease characterized by an increase in airway reactivity together with a propensity for the airways to constrict in response to a variety of stimuli.1 The cumulative prevalence of this disorder in America is estimated to be between 5 and 7 percent.2 Prompt, regular, and aggressive therapy with inhaled beta-adrenergic agents, theophylline ...
G R, Cott, R M, Cherniack
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Steroid derivatives as inhibitors of steroid sulfatase
The Journal of Steroid Biochemistry and Molecular Biology, 2013Sulfated steroids function as a storage reservoir of biologically active steroid hormones. The sulfated steroids themselves are biologically inactive and only become active in vivo when they are converted into their desulfated (unconjugated) form by the enzyme steroid sulfatase (STS).
Yaser A, Mostafa, Scott D, Taylor
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Non-Steroidal Steroid Receptor Modulators
Current Medicinal Chemistry, 2005The last ten years much attention has been focused on the finding of non-steroidal ligands for steroidal nuclear receptors for reasons such as diminishing cross-reactivity to eliminate side effect profiles, changing physicochemical properties which might cause different tissue distribution profiles and altering binding modes which influence the binding
Rogier C, Buijsman +4 more
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Steroid structure and steroid activity
British Journal of Dermatology, 1976The diverse biological effects associated with naturally occurring steroids are reviewed, with particular reference to the effect upon biological activity of changes in chemical structure. The motives for synthetic modification of the natural products are discussed and are illustrated by reference to the development of systemic and topical anti ...
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Steroidal and Non-Steroidal Inhibitors of Steroid Sα-Reductase
Current Medicinal Chemistry, 1995Abstract: A good deal of interest exists in developing inhibitors of steroid Sa-reductase (SR) as a therapy for pharmacological disorders associated with elevated levels of dihydrotestosterone (DHT), the product of SR action on testosterone (T). The recent identification of two isoforms of SR (Types 1 and 2) has intensified this effort to include the ...
A.D. Abell, B.R. Henderson
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Steroids, steroid receptors and disease
Trends in Molecular Medicine, 2001Abstract The 672nd Biochemical Society meeting was held at Sussex University, UK, from 19 to 21 December 2000. One session was dedicated to the study of steroids and their receptors, and related diseases.
Helen Wiseman, Rosanna Duffy
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Journal of Steroid Biochemistry, 1975
Abstract The unopposed continuous administration of biologically active estrogenic materials produces a wide variety of cancers in experimental animals. Most of these cancers occur in the target tissues for estrogenic activity and appear to be characteristic of the animal rather than the estrogens.
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Abstract The unopposed continuous administration of biologically active estrogenic materials produces a wide variety of cancers in experimental animals. Most of these cancers occur in the target tissues for estrogenic activity and appear to be characteristic of the animal rather than the estrogens.
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Steroids, neuroactive steroids and neurosteroids in psychopathology
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005The term "neurosteroid" (NS) was introduced by Baulieu in 1981 to name a steroid hormone, dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long after gonadectomy and adrenalectomy, and shown later to be synthetized by the brain.
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The Laryngoscope, 1989
AbstractA prospective double‐blind randomized pilot study was performed to test the benefits of steroids versus placebo in controlling edema and ecchymosis in rhinoplasty within the immediate postoperative period. Thirty consecutive patients who underwent rhinoplasty with osteotomies were entered into the study.
W S, Griffies +4 more
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AbstractA prospective double‐blind randomized pilot study was performed to test the benefits of steroids versus placebo in controlling edema and ecchymosis in rhinoplasty within the immediate postoperative period. Thirty consecutive patients who underwent rhinoplasty with osteotomies were entered into the study.
W S, Griffies +4 more
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Steroid-Induced, Steroid-Producing, and Steroid-Responsive Tumors
1976As an introduction to the chapters to follow, this report will aim to present certain hopefully provocative observations on the nature of steroid-related tumors in man and animals.
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