Results 91 to 100 of about 429,473 (311)

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)

Molecules, 2007
Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj   +1 more source

Distinction between epimeric 3-hydroxi steroids by mass analyzed ion kinetic energy spectrometry [PDF]

, 1982
Gonzalez JE, Grützmacher H-F. Distinction between epimeric 3-hydroxi steroids by mass analyzed ion kinetic energy spectrometry. Organic Mass Spectrometry.
Gonzalez, Jaime Espinosa, Grützmacher, Hans-Friedrich   +1 more
core   +1 more source

Highly Potent and Moderately Potent Topical Steroids Are Effective in Treating Phimosis: A Prospective Randomized Study. Miscellaneous

, 2008
Purpose: We report a prospective randomized study comparing the effects of highly potent and moderately potent topical steroids in treating pediatric phimosis.
楊緒棣;蔡曜州;劉詩彬;王炯珵, YANG, STEPHEN SHEI-DEI;TSAI, YAO-CHOU;LIU, SHIH-PING;WANG, CHUNG-CHENG   +1 more
core  

17-hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

, 2008
The question addressed in this study was the nature of the enzyme required to remove the side-chain of 17-hydroxycorticosteroids, leading in the case of cortisol to the excretion of 11 beta-hydroxyandrosterone, 11-oxo-androsterone and the corresponding ...
Kater, Claudio E. [UNIFESP], Neres, Marcos S. [UNIFESP], Stewart, Paul M., Hughes, Beuerly A., Shackleton, Cedric H. L.   +4 more
core   +1 more source

Steroids accumulate in the rearing water of commercial recirculating aquaculture systems [PDF]

, 2014
Little information is available on steroid concentrations in the rearing water of aquaculture systems and whether they accumulate in recirculating aquaculture systems (RAS).
Mota, V.C., Martins, C.I., Verreth, J.A.J., Verreth, Johan, Martins, Catarina I. M., Eding, E.H., Eding, Ep, Mota, Vasco, Canário, A.V.M., Canario, Adelino V. M.   +9 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology

, 2001
Besides their binding to cognate intracellular receptors gonadal steroids may also act as functional antagonists at the 5-HT3 receptor. A structure-activity relationship for the actions of a variety of steroids at the 5-HT3 receptor was elaborated that ...
Holsboer F., Lancel M., Rupprecht R., Di Michele F., Hermann B., Strohle A., Lancel M., Romeo E., Holsboer F., Hermann B., Di Michele F., Strohle A., Rupprecht R., ROMEO, ELENA   +7 more
core   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source