Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Screening Study of the Inhibitory Effects 17 Steroids on 6 Major Cytochrome P450 Isoenzymes
, 2001 Objective: To screen the inhibitory effects of 17 steroids on 6 major cytochrome P450 (CYP) isoenzymes. Methods: The inhibitory effects of 17 steroids at 100 μM (25 μM for estrone) were tested towards 6 major CYPs including CYP1A2, CYP2A6, CYP2C9, CYP2D6,
张江伟, 李巍, 刘勇, 杨凌
core
Problems in the use of chemical and functional nomenclatures for steroids in human physiology, biology and pharmacology. [PDF]
RSC AdvHonour JW.
europepmc +1 more source
Advances in Cancer Immunotherapy for Solid Tumors
Advanced Science, EarlyView.Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz +1 more
wiley +1 more source
Clinical Outcomes of Adjunctive Corticosteroid Therapy Versus Standard Treatment Alone in Patients With Bacterial Facial Infections: A Systematic Review and Meta-Analysis. [PDF]
Clin Exp Dent ResHussain U +11 more
europepmc +1 more source
Advanced Science, EarlyView.This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim +8 more
wiley +1 more source
Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography-Tandem Mass Spectrometry. [PDF]
Anal Sci AdvBain JT +4 more
europepmc +1 more source
From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance
Advanced Science, EarlyView.Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu +6 more
wiley +1 more source
Respiratory effects of off label anakinra in critically ill neonates: a 15-patient observational cohort study. [PDF]
Front PediatrDe Rose DU +7 more
europepmc +1 more source
Biomarkers of Sarcopenia: Current Status and Future Perspectives
AGING MEDICINE, EarlyView.In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo +6 more
wiley +1 more source