Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy [PDF]
Frontiers in Oncology, 2023 Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
doaj +7 more sources
Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor [PDF]
Nature Communications, 2020 Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters.
Chengcheng Guan +9 more
doaj +8 more sources
Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids [PDF]
Communications BiologyViruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis ...
Anja Schöbel +7 more
doaj +6 more sources
New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440 [PDF]
Molecules, 2020 New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440.
Elyza Aiman Azizah Nur +4 more
doaj +9 more sources
Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses [PDF]
Communications Biology, 2021 Sun et al. show that hepatitis C virus or free-fatty acids increase lipid droplets and apolipoprotein J (ApoJ) expression while ApoJ silencing alleviates hepatic lipid accumulation.
Hung-Yu Sun +4 more
doaj +9 more sources
Functional Analysis of Sterol O-Acyltransferase Involved in the Biosynthetic Pathway of Pachymic Acid in Wolfiporia cocos [PDF]
Molecules, 2021 Pachymic acid from Wolfiporia cocos possesses important medicinal values including anti-bacterial, anti-inflammatory, anti-viral, invigorating, anti-rejection, anti-tumor, and antioxidant activities.
Wenjun Zhu +7 more
doaj +8 more sources
Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma [PDF]
Frontiers in Oncology, 2022 Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyang Guo +13 more
doaj +7 more sources
Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis. [PDF]
PLoS ONE, 2016 To elucidate whether Sterol O-acyltransferase (Soat) mediates the absorption and transportation of yolk lipids to the developing embryo, zebrafish soat1 and soat2 were cloned and studied.
Nai-Yun Chang +5 more
doaj +8 more sources
Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion. [PDF]
PLoS ONE, 2014 The primary risk factor for atherosclerotic cardiovascular disease is LDL cholesterol, which can be reduced by increasing cholesterol excretion from the body.
Stephanie M Marshall +10 more
doaj +8 more sources
Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186. [PDF]
Appl Environ Microbiol, 2023 Thraustochytrids are marine microorganisms expected to produce useful lipids. They synthesize polyunsaturated fatty acids and sterols and store them in lipid droplets as a form of triacylglycerol (TG) and sterol ester (SE), respectively.
Ishibashi Y +8 more
europepmc +3 more sources