Results 91 to 100 of about 13,985 (173)

Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal

Journal of Clinical Endocrinology and Metabolism, 2011
We used up- and down-regulation of the nuclear receptor steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) to identify new components of adrenal function and steroidogenesis.
B. Ferraz-de-Souza, R. Hudson-Davies, Lin Lin, R. Parnaik, M. Hubank, M. Dattani, J. Achermann   +6 more
semanticscholar   +1 more source

TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway

Annals of Medicine
Background tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies.
Qianyi Qi, Bairong Chen, Jinran Wu, Jing Xu, Hongyi Bao, Kangfeng Jin, Lin Chen, Guang Zhu, Feng Wang   +8 more
doaj   +1 more source

SOAT1 exacerbates tumor progression by promoting YAP signaling activation and attenuating endoplasmic reticulum stress

View
Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang, Qianyu Li, Yifei Qian, Yu Tong, Songling Li, Wenyun Guo, Linfeng Li, Zijun Zhu, Wei‐Qiang Gao, Yanfeng Liu   +9 more
doaj   +1 more source

Penthorum chinense Pursh extract ameliorates alcohol-related fatty liver disease in mice via the SIRT1/AMPK signaling axis

Heliyon
Penthorum chinense Pursh (P. chinense), a functional food, has been applied to protect the liver against alcohol-related fatty liver disease (ALD) for a long history in China.
Hui Zhuge, Yan Pan, Shanglei Lai, Kaixin Chang, Qinchao Ding, Wenjing Cao, Qing Song, Songtao Li, Xiaobing Dou, Bin Ding   +9 more
doaj   +1 more source

Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling

The EMBO Journal
Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood.
Ábel Szkalisity, Lauri Vanharanta, Hodaka Saito, Csaba Vörös, Shiqian Li, Antti Isomäki, Teemu Tomberg, Clare Strachan, Ilya Belevich, Eija Jokitalo, Elina Ikonen   +10 more
doaj   +1 more source

Structure of nevanimibe-bound tetrameric human ACAT1. [PDF]

Nature, 2020
Long T, Sun Y, Hassan A, Qi X, Li X.
europepmc   +1 more source

Stopping SOAT1 sparks an immune attack on liver cancer: a metabolic-immune axis in hepatocellular carcinoma

Oncologie
Ma et al. identified sterol O-acyltransferase 1 (SOAT1) as a key metabolic-immune node in hepatocellular carcinoma (HCC). These authors revealed that SOAT1 loss induced ROS-driven ER stress that activates IKKβ-NF-κB signaling and up-regulates the ...
Lonardo Amedeo, Weiskirchen Ralf
doaj   +1 more source

Correlation of SOAT1 and TREM1 expression with clinicopathological features and prognosis in esophageal squamous cell carcinoma

Zhongguo linchuang yanjiu
"Objective To investigate the mRNA expression levels of sterol O⁃acyltransferase 1（SOAT1）and triggering receptor expressed on myeloid cells 1（TREM1）in esophageal squamous cell carcinoma（ESCC）tissues and analyze their associations with clinical ...
LU Yang，GAO Chao
doaj   +1 more source

Sterol O-acyltransferase 1 (SOAT1; ACAT1) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Subcellular localization of sterol O-acyltransferase from Arabidopsis thaliana expressed in Nicotiana tabacum

, 2014
Lisa Maria Volleritsch Zsfassungen in dt. und engl.
openaire