Results 91 to 100 of about 11,790 (158)
ABSTRACT Background and Aim Metabolic dysfunction associated steatotic liver disease (MASLD) is the predominant cause of chronic liver disease, with dysregulation of bile acid (BA) metabolism and intestinal microbiota being intricately associated with MASLD progression.
Junjun Wang+7 more
wiley +1 more source
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang+20 more
doaj +1 more source
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood+8 more
wiley +1 more source
Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang+13 more
doaj +1 more source
Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis.
Yahui Zhu+10 more
doaj +1 more source
Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Su-Myat Khine K+8 more
doaj +1 more source
Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang+9 more
doaj +1 more source
Structure of nevanimibe-bound tetrameric human ACAT1. [PDF]
Long T, Sun Y, Hassan A, Qi X, Li X.
europepmc +1 more source
Quantitative analysis of the expression of ACAT 1 genes in human tissues by real-time PCR2
ACAT (also called sterol o-acyltransferase) catalyzes the esterification of cholesterol by reaction with long-chain acyl-CoA derivatives and plays a pivotal role in the regulation of cholesterol homeostasis.
Jeffery L. Smith+8 more
doaj