Results 91 to 100 of about 5,934 (155)

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu   +10 more
wiley   +1 more source

Endoplasmic Reticulum Stress in Cancer

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Persistent ER stress in tumors activates UPR sensors (IRE1α, PERK, ATF6), driving cancer proliferation, metastasis, immune evasion, and drug resistance. This review explores UPR‐mediated signaling crosstalk, angiogenesis, and therapeutic targeting to develop safer anticancer strategies.
Ruixin Zhou   +5 more
wiley   +1 more source

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

open access: yesNature Communications
Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang   +13 more
doaj   +1 more source

The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation

open access: yesExperimental Physiology, Volume 110, Issue 7, Page 936-948, 1 July 2025.
Abstract In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non‐lipid precursors, intrahepatic lipid droplets and recycling ...
Kieran Smith   +2 more
wiley   +1 more source

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

open access: yesLipids in Health and Disease, 2010
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Su-Myat Khine K   +8 more
doaj   +1 more source

SOAT1 exacerbates tumor progression by promoting YAP signaling activation and attenuating endoplasmic reticulum stress

open access: yesView
Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang   +9 more
doaj   +1 more source

Structure of nevanimibe-bound tetrameric human ACAT1. [PDF]

open access: yesNature, 2020
Long T, Sun Y, Hassan A, Qi X, Li X.
europepmc   +1 more source

Quantitative analysis of the expression of ACAT 1 genes in human tissues by real-time PCR2

open access: yesJournal of Lipid Research, 2004
ACAT (also called sterol o-acyltransferase) catalyzes the esterification of cholesterol by reaction with long-chain acyl-CoA derivatives and plays a pivotal role in the regulation of cholesterol homeostasis.
Jeffery L. Smith   +8 more
doaj  

The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol <i>O</i>-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice

open access: gold, 2020
Taichi Ohshiro   +7 more
openalex   +2 more sources

Home - About - Disclaimer - Privacy