Results 91 to 100 of about 11,790 (158)

Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota

open access: yesJournal of Gastroenterology and Hepatology, Volume 40, Issue 8, Page 2091-2103, August 2025.
ABSTRACT Background and Aim Metabolic dysfunction associated steatotic liver disease (MASLD) is the predominant cause of chronic liver disease, with dysregulation of bile acid (BA) metabolism and intestinal microbiota being intricately associated with MASLD progression.
Junjun Wang   +7 more
wiley   +1 more source

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

open access: yesNature Communications
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang   +20 more
doaj   +1 more source

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

open access: yesExperimental Physiology, Volume 110, Issue 8, Page 1071-1086, 1 August 2025.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood   +8 more
wiley   +1 more source

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

open access: yesNature Communications
Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang   +13 more
doaj   +1 more source

Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice

open access: yesJCI Insight, 2022
Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis.
Yahui Zhu   +10 more
doaj   +1 more source

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study

open access: yesLipids in Health and Disease, 2010
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Su-Myat Khine K   +8 more
doaj   +1 more source

SOAT1 exacerbates tumor progression by promoting YAP signaling activation and attenuating endoplasmic reticulum stress

open access: yesView
Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang   +9 more
doaj   +1 more source

Structure of nevanimibe-bound tetrameric human ACAT1. [PDF]

open access: yesNature, 2020
Long T, Sun Y, Hassan A, Qi X, Li X.
europepmc   +1 more source

Quantitative analysis of the expression of ACAT 1 genes in human tissues by real-time PCR2

open access: yesJournal of Lipid Research, 2004
ACAT (also called sterol o-acyltransferase) catalyzes the esterification of cholesterol by reaction with long-chain acyl-CoA derivatives and plays a pivotal role in the regulation of cholesterol homeostasis.
Jeffery L. Smith   +8 more
doaj  

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