Results 111 to 120 of about 19,805 (217)

Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad

European Journal of Clinical Investigation, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano, Enes Erul, Roberto Nilo, Davide Nilo, Vincenzo Russo, Luca Rinaldi, Carlo Acierno, Erman Akkus, Katerina Koudelkova, Federica Cerini, Alessandro Rizzo, Ferdinando Carlo Sasso, Leonilde Bonfrate, Antonio Giordano, Hatime Arzu Yaşar, Caterina Conte   +15 more
wiley   +1 more source

Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function [PDF]

, 2017
It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signalling platforms called lipid rafts, essential for T-cell activation and function.
Adlanmerini, Aktas, al Yacoub, Araldi, Ashdown, Balamuth, Bensinger, Bovenga, Brown, Burridge, Chaudhri, Cho, Clark, Daniel, Degroote, Della Torre, Dimeloe, Dunn, Fievet, Foryst-Ludwig, Fox, Gaudet, Gervois, Greenwood, Griffié, Guo, Harris, Herold, Horton, Hughes, Ifergan, Iida, Ikonen, Ishikawa, Ito, Janes, Jeong, Jones, Jury, Jury, Jury, Kanakasabai, Keller, Kidani, Kidani, Kidani, Kirchgessner, Kishimoto, Klein, Kosters, Köberlin, Lappano, Lee, Levental, Levental, Levin, Lingwood, Lisse, Lovett-Racke, Lund, Luquet, Magee, McDonald, Megha, Mesmin, Miguel, Molnár, Nagafuku, Nazarov-Stoica, Ngo, Nuñez, Oliver, Owen, Owen, Pelekanou, Phiel, Quinet, Radhakrishnan, Repa, Rong, Rubin-Delanchy, Sankaran-Walters, Simigdala, Simons, Spann, Steffensen, Sun, Svenson, Swamy, Swinnen, Tang, Tcherepanova, Thangavel, Uppal, Uppal, Varga, Waddington, Waddington, Walcher, Wang, Wang, Wang, Wang, Wang, Wu, Yang, Youssef, Zalba, Zelcer, Zhu   +109 more
core   +2 more sources

Duckweeds: Model organisms for research on plant sterols and steroids

Plant Biology, EarlyView.
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
J. Klein, K.‐J. Appenroth, K. S. Sree
wiley   +1 more source

Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity

The Journal of Clinical Investigation, 2023
Sphingolipids function as membrane constituents and signaling molecules, with crucial roles in human diseases, from neurodevelopmental disorders to cancer, best exemplified in the inborn errors of sphingolipid metabolism in lysosomes. The dihydroceramide
Laura Planas-Serra, Nathalie Launay, Leire Goicoechea, Bénédicte Heron, Cristina Jou, Natalia Juliá-Palacios, Montserrat Ruiz, Stéphane Fourcade, Carlos Casasnovas, Carolina De La Torre, Antoinette Gelot, Maria Marsal, Pablo Loza-Alvarez, Àngels García-Cazorla, Ali Fatemi, Isidre Ferrer, Manel Portero-Otin, Estela Area-Gómez, Aurora Pujol   +18 more
doaj   +1 more source

Lipotoxicity in the liver [PDF]

, 2013
Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21st century.
Bánhegyi, Gábor, Csala, Miklós, Kereszturi, Éva, Simon-Szabó, Laura, Szelényi, Péter, Zámbó, Veronika   +5 more
core   +2 more sources

Diagnostics of Autoimmune Hepatitis Enabled by Non‐Invasive Clinical Proteomics

Alimentary Pharmacology &Therapeutics, Volume 62, Issue 9, Page 901-919, November 2025.
Mass‐spectrometry‐based proteomic analyses of paired liver‐plasma samples from patients with AIH enabled discovery of numerous proteins showing high diagnostic accuracy. Proteomics may constitute a novel non‐invasive diagnostic tool for AIH if validated in larger, age‐ and sex‐matched cohorts.
Anne‐Sofie Houlberg Jensen, Henriette Ytting, Annelaura Bach Nielsen, Mikkel Parsberg Werge, Elias Badal Rashu, Liv Eline Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Anders Ellekær Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza Rafiolsadat Serizawa, Marie Winther‐Sørensen, Jesper Sloth Kellemann, Lise Lotte Gluud, Nicolai Jacob Wewer Albrechtsen   +20 more
wiley   +1 more source

Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells [PDF]

, 2009
Sterol regulatory element-binding proteins (SREBPs)-1c and -2, which were initially discovered as master transcriptional regulators of lipid biosynthesis and uptake, were recently identified as novel transcriptional regulators of the sodium-iodide ...
Rauer, Christine, Ringseis, Robert, Rothe, Susanne, Wen, Gaiping, Eder, Klaus   +4 more
core   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
core   +2 more sources

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Health and Diseases

MedComm, Volume 6, Issue 10, October 2025.
As pivotal regulators in diverse physiological and pathological processes, mitochondria‐associated endoplasmic reticulum membranes (MAMs) are critically involved in both health and diseases, including cancers, neurodegenerative disorders, metabolic diseases, cardiovascular diseases.
Hangnan Hong, Zhenyang Guo, Junbo Ge, Hua Li   +3 more
wiley   +1 more source