Results 111 to 120 of about 14,545 (218)
Environmental Toxicology, Volume 41, Issue 1, Page 18-32, January 2026.ABSTRACT Cadmium (Cd), a heavy metal, disrupts the structure of seminiferous tubules and induces cell death at multiple stages of sperm development. Cd also impairs Leydig cells (LCs), resulting in reduced serum testosterone (T) levels. This study primarily examined the impact of Cd on the mitochondrial compartment and mitochondrial‐associated ...
Debora Latino +7 more
wiley +1 more source
Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity
The Journal of Clinical Investigation, 2023 Sphingolipids function as membrane constituents and signaling molecules, with crucial roles in human diseases, from neurodevelopmental disorders to cancer, best exemplified in the inborn errors of sphingolipid metabolism in lysosomes. The dihydroceramide
Laura Planas-Serra +18 more
doaj +1 more source
Cholesterol Metabolism and Its Regulation by Functional Foods [PDF]
, 2016 Currently, obesity is considered an epidemic due to the disruptions it causes to health, highlighting the incensement in cardiovascular diseases associated with cholesterol and low-density lipoprotein (LDL) high concentrations.
Cristian, J. (Jimenez-Martinez) +4 more
core +1 more source
Brain Pathology, Volume 36, Issue 1, January 2026.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Advanced ScienceEffective inhibition of intestinal lipid uptake is an efficient strategy for the treatment of disorders related to lipid metabolism. Sterol O‐acyltransferase 2 (SOAT2) is responsible for the esterification of free cholesterol and fatty acids into ...
Jingjia Liang +12 more
doaj +1 more source
European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano +15 more
wiley +1 more source
Lipotoxicity in the liver [PDF]
, 2013 Obesity due to excessive food intake and the lack of physical activity is becoming one of the most serious public health problems of the 21st century.
Bánhegyi, Gábor +5 more
core +2 more sources
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli +12 more
wiley +1 more source
Molecular Ecology, Volume 35, Issue 1, January 2026.ABSTRACT Colour polytypism represents an example of phenotypic diversification shaped by genetic divergence and ecological pressures. Poison frogs of the genus Oophaga (Dendrobatidae) are highly polytypic in coloration, making them an ideal system for investigating the genetic and physiological basis of colour variation.
Vasiliki Mantzana‐Oikonomaki +7 more
wiley +1 more source