Results 121 to 130 of about 14,545 (218)

The optimization of crop response to climatic stress through modulation of plant stress response mechanisms. Opportunities for biostimulants and plant hormones to meet climate challenges.

New Phytologist, Volume 249, Issue 1, Page 130-151, January 2026.
Summary This review discusses the use of agronomic management practices to enhance crop stress resilience to climate stress through the modulation of natural plant growth regulatory pathways. The use of biostimulants or plant hormones to improve crop resilience is subject to strict regulatory oversight if changes in the regulation of plant growth are ...
Jing Li, Giulia Forghieri, Danny Geelen, Patrick du Jardin, Patrick H. Brown   +4 more
wiley   +1 more source

Effect of supplementation with different fat sources on the mechanisms involved in reproductive performance in lactating dairy cattle [PDF]

, 2012
peer reviewedSupplementary fat positively influences reproductive performance in dairy cattle, although the mechanisms involved are not clearly defined. Our objective was to determine the effects of four different fat supplements on follicle development,
Butler, Stephen, Dewhurst, Richard J., Evans, A.C.O., Hennessy, Alan A., Hutchinson, Ian A., Lonergan, P., Waters, Sinead M.   +6 more
core   +1 more source

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage

New Phytologist, Volume 249, Issue 2, Page 892-916, January 2026.
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain largely unexplored.
Patricia Scholz, Janis Dabisch, Ana C. Vilchez, Alyssa C. Clews, Philipp W. Niemeyer, Magdiel S. S. Lim, Siqi Sun, Lea Hembach, Mayuko Naganawa, Fabienne Dreier, Katharina F. Blersch, Lea M. Preuß, Martin Bonin, Elena Lesch, Yuya Iwai, Takashi L. Shimada, Jürgen Eirich, Iris Finkemeier, Katharina Gutbrod, Peter Dörmann, You Wang, Robert T. Mullen, Till Ischebeck   +22 more
wiley   +1 more source

An omics-based characterization of Wolfiporia cocos reveals three CYP450 members involved in the biosynthetic pathway of pachymic acid

Communications Biology
Wolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with therapies. Nowadays, the unknown PA biosynthesis leads to difficulties in increasing its content in W.
Heping Liu, Naliang Jing, Fengfeng Li, Keyue Wang, Jing Tang, Qin Zhao, Yipeng Zhang, Hamza Armghan Noushahi, Ran Xu, Xuekui Wang, Wenjun Zhu, Shengqiu Feng, Shaohua Shu, Zhinan Mei   +13 more
doaj   +1 more source

Duckweeds: Model organisms for research on plant sterols and steroids

Plant Biology, Volume 28, Issue 1, Page 18-30, January 2026.
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
J. Klein, K.‐J. Appenroth, K. S. Sree
wiley   +1 more source

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

Nature Communications
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen   +20 more
doaj   +1 more source

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Nature Communications
Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu   +13 more
doaj   +1 more source

Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential

, 2022
Pinaki Bhattacharjee, Nicholas Rutland, Malliga R. Iyer   +2 more
openalex   +1 more source

Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFβ pathway in endodermal epithelial cells of Japanese quail [PDF]

, 2019
Han‐Jen Lin, Chiao-Wei Lin, Harry J. Mersmann, Shih‐Torng Ding   +3 more
openalex   +1 more source

Quantitative analysis of the expression of ACAT 1 genes in human tissues by real-time PCR2

Journal of Lipid Research, 2004
ACAT (also called sterol o-acyltransferase) catalyzes the esterification of cholesterol by reaction with long-chain acyl-CoA derivatives and plays a pivotal role in the regulation of cholesterol homeostasis.
Jeffery L. Smith, Kavitha Rangaraj, Robert Simpson, Donald J. Maclean, Les K. Nathanson, Katherine A. Stuart, Shaun P. Scott, Grant A. Ramm, John de Jersey   +8 more
doaj   +1 more source