Results 121 to 130 of about 19,805 (217)

siRNA/CS‐PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity

Advanced Science
Effective inhibition of intestinal lipid uptake is an efficient strategy for the treatment of disorders related to lipid metabolism. Sterol O‐acyltransferase 2 (SOAT2) is responsible for the esterification of free cholesterol and fatty acids into ...
Jingjia Liang, Wentao Shao, Pu Ni, Qian Liu, Weirui Kong, Weiyi Shen, Qihan Wang, Anhua Huang, Guixin Zhang, Yulong Yang, Hongliang Xin, Zhaoyan Jiang, Aihua Gu   +12 more
doaj   +1 more source

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, Volume 55, Issue 10, October 2025.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Cropland‐To‐Miscanthus Conversion Increases Sulfur Availability and Shifts Microbial Pattern Enhancing Sulfur Cycle in Northern China

GCB Bioenergy, Volume 17, Issue 10, October 2025.
Long‐term cultivation of Miscanthus without fertilization, shows great potential in bioenergy and ecological services, significantly modifies soil microbial communities and the sulfur cycle. 15‐years Miscanthus fields showed substantial increases in soil sulfate (SO42−, 47.4%), total sulfur (13.3%), and available sulfur (156.4%), alongside an 8.8 ...
Zhenyu Fan, Ting Wu, Aoxiang Chang, Cui Li, Mei Zheng, Yu Sun, Jinku Song, Chunqiang Xing, Na Wu, Aiying Yang, Xiuyun Wan, Chunyu Sun, Jinliang Chen, Qiang Guo, Chunqiao Zhao, Xifeng Fan   +15 more
wiley   +1 more source

Overexpression of jojoba wax ester synthase in poplar increases foliar lipid accumulation, alters stomatal conductance, and increases water use efficiency

Plant Biology, Volume 27, Issue 6, Page 1006-1021, October 2025.
Overexpression of jojoba wax ester synthase in poplar causes accumulation of intracellular lipids in leaves and reduced stomatal conductance with higher water‐use efficiencies in the transgenic lines. Abstract Poplars are important fast‐growing, water‐spending biomass tree crops.
A. Amirkhosravi, G.‐J. Strijkstra, A. Keyl, F. Häffner, U. Lipka, C. Herrfurth, I. Feussner, A. Polle   +7 more
wiley   +1 more source

Cholesterol Metabolism and Its Regulation by Functional Foods [PDF]

, 2016
Currently, obesity is considered an epidemic due to the disruptions it causes to health, highlighting the incensement in cardiovascular diseases associated with cholesterol and low-density lipoprotein (LDL) high concentrations.
Cristian, J. (Jimenez-Martinez), David, B. (Betancur-Ancona), Gloria, D. (Davila-Ortiz), Luis, C. (Chel-Guerrero), Yasser, C. (Chim-Chi)   +4 more
core   +1 more source

An omics-based characterization of Wolfiporia cocos reveals three CYP450 members involved in the biosynthetic pathway of pachymic acid

Communications Biology
Wolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with therapies. Nowadays, the unknown PA biosynthesis leads to difficulties in increasing its content in W.
Heping Liu, Naliang Jing, Fengfeng Li, Keyue Wang, Jing Tang, Qin Zhao, Yipeng Zhang, Hamza Armghan Noushahi, Ran Xu, Xuekui Wang, Wenjun Zhu, Shengqiu Feng, Shaohua Shu, Zhinan Mei   +13 more
doaj   +1 more source

Effect of supplementation with different fat sources on the mechanisms involved in reproductive performance in lactating dairy cattle [PDF]

, 2012
peer reviewedSupplementary fat positively influences reproductive performance in dairy cattle, although the mechanisms involved are not clearly defined. Our objective was to determine the effects of four different fat supplements on follicle development,
Butler, Stephen, Dewhurst, Richard J., Evans, A.C.O., Hennessy, Alan A., Hutchinson, Ian A., Lonergan, P., Waters, Sinead M.   +6 more
core   +1 more source

Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds

Nature Communications
The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen   +20 more
doaj   +1 more source

Quantitative analysis of the expression of ACAT 1 genes in human tissues by real-time PCR2

Journal of Lipid Research, 2004
ACAT (also called sterol o-acyltransferase) catalyzes the esterification of cholesterol by reaction with long-chain acyl-CoA derivatives and plays a pivotal role in the regulation of cholesterol homeostasis.
Jeffery L. Smith, Kavitha Rangaraj, Robert Simpson, Donald J. Maclean, Les K. Nathanson, Katherine A. Stuart, Shaun P. Scott, Grant A. Ramm, John de Jersey   +8 more
doaj   +1 more source