Results 131 to 140 of about 12,786 (155)
Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling. [PDF]
EMBO JSzkalisity Á +10 more
europepmc +1 more source
ER-plastid contact sites as molecular crossroads for plastid lipid biosynthesis. [PDF]
BMC BiolHuercano C +4 more
europepmc +1 more source
Roles of plasma proteins in mediating the causal effect of the lipid species on gastric cancer: Insights from proteomic and two-step Mendelian randomization. [PDF]
Medicine (Baltimore)Dong Z +6 more
europepmc +1 more source
Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209 [PDF]
The Journal of Antibiotics, 2016 The enzyme sterol O-acyltransferase (SOAT, also known as acyl-CoA:cholesterol acyltransferase (ACAT)), an endoplasmic reticulum membrane protein, has important roles in cholesterol regulation in humans.1 SOAT is expected to be a promising target for the development of new anti-atherosclerotic agents.
Keisuke Kobayashi +4 more
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Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440
The Journal of Antibiotics, 2020New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties.
Kanji Hosoda +6 more
openaire +3 more sources
The Role of Sterol O-acyltransferase 1 In Obesity And In Prostate Cancer
2023ABSTRACT The worldwide obesity prevalence has almost tripled since 1973 according to the World Health Organization. In the United States, the disease is especially prevalent, with a recorded prevalence of 41.9 percent in 2017, as reported by the National Health and Nutrition Examination Survey.
openaire +1 more source
The Journal of Antibiotics, 2018
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR.
Ryuji Uchida +6 more
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New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR.
Ryuji Uchida +6 more
openaire +2 more sources
Prostaglandins & Other Lipid Mediators, 2021
Prostate cancer (PCa) is one of the most fatal malignant tumors that occurs in the prostate epithelium, especially in older men, the mortality of which ranks sixth among all cancer-related deaths. It has been urgently needed to elucidate the pathogenesis of PCa and provide promising therapeutic targets for PCa treatment. The Sterol O-acyltransferase 1 (
Yuye Wu +4 more
openaire +3 more sources
Prostate cancer (PCa) is one of the most fatal malignant tumors that occurs in the prostate epithelium, especially in older men, the mortality of which ranks sixth among all cancer-related deaths. It has been urgently needed to elucidate the pathogenesis of PCa and provide promising therapeutic targets for PCa treatment. The Sterol O-acyltransferase 1 (
Yuye Wu +4 more
openaire +3 more sources
The Journal of Antibiotics, 2018
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the fungus Aspergillus nidulans BF-0142 along with a known helvafuranone (3). The structures of 1 and 2 were elucidated based on spectroscopic analyses by the interpretation of one-dimensional and two-dimensional nuclear magnetic ...
Takun Furukawa +7 more
openaire +2 more sources
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the fungus Aspergillus nidulans BF-0142 along with a known helvafuranone (3). The structures of 1 and 2 were elucidated based on spectroscopic analyses by the interpretation of one-dimensional and two-dimensional nuclear magnetic ...
Takun Furukawa +7 more
openaire +2 more sources