Results 131 to 140 of about 13,985 (173)

Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet.

Biochemical and Biophysical Research Communications, 2018
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice
N. Xu, Hao Meng, Tianyi Liu, Yingli Feng, Yuan Qi, Donghuan Zhang, Hong-lei Wang   +6 more
semanticscholar   +3 more sources

Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440

The Journal of Antibiotics, 2020
New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties.
Taichi Ohshiro, H. Morita, Elyza Aiman Azizah Nur, Kanji Hosoda, R. Uchida, H. Tomoda   +5 more
semanticscholar   +4 more sources

Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential.

Journal of Medicinal Chemistry, 2022
Sterol O-acyltransferase (SOAT) is a membrane-bound enzyme that aids the esterification of cholesterol and fatty acids to cholesterol esters. SOAT has been studied extensively as a potential drug target, since its inhibition can serve as an alternative ...
Pinaki Bhattacharjee, Nicholas Rutland, Malliga R. Iyer   +2 more
semanticscholar   +1 more source

Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209

The Journal of Antibiotics, 2016
The enzyme sterol O-acyltransferase (SOAT, also known as acyl-CoA:cholesterol acyltransferase (ACAT)), an endoplasmic reticulum membrane protein, has important roles in cholesterol regulation in humans.1 SOAT is expected to be a promising target for the development of new anti-atherosclerotic agents.
A. Suzuki, T. Fukuda, Keisuke Kobayashi, Taichi Ohshiro, H. Tomoda   +4 more
semanticscholar   +3 more sources

Measurement of human sterol-o-acyltransferase 1, soat1 levels in Iraqi diabetic patients

International Journal of Chemical and Biological Sciences
H. Abed
semanticscholar   +2 more sources

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase

The Journal of Antibiotics
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR.
Elyza Aiman Azizah Nur, Keisuke Kobayashi, Rio Tejima, Yosuke Katada, Hiroshi Tomoda, Taichi Ohshiro   +5 more
semanticscholar   +3 more sources

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142

The Journal of Antibiotics, 2018
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the fungus Aspergillus nidulans BF-0142 along with a known helvafuranone (3). The structures of 1 and 2 were elucidated based on spectroscopic analyses by the interpretation of one-dimensional and two-dimensional nuclear magnetic ...
T. Fukuda, Takun Furukawa, Keisuke Kobayashi, Kenichiro Nagai, R. Uchida, H. Tomoda   +5 more
semanticscholar   +3 more sources

Heterologous Biosynthesis of the Sterol O-Acyltransferase Inhibitor Helvamide Unveils an α-Ketoglutarate-Dependent Cross-Linking Oxygenase.

Organic Letters
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. Heterologous expression of hvm in A.
Rui Wang, Jia-Jing Liang, Wen-Chia Yang, Daniel Vuong, J. Kalaitzis, Alastair E Lacey, Ernest Lacey, Andrew M. Piggott, Y. Chooi, Hang Li   +9 more
semanticscholar   +1 more source

The Role of Sterol O-acyltransferase 1 In Obesity And In Prostate Cancer

2023
ABSTRACT The worldwide obesity prevalence has almost tripled since 1973 according to the World Health Organization. In the United States, the disease is especially prevalent, with a recorded prevalence of 41.9 percent in 2017, as reported by the National Health and Nutrition Examination Survey.
openaire   +1 more source

miRNAs regulate the expression of sterol‐O acyltransferase 1 through inhibiting the 3′UTR of TGFβ receptor type 1 during embryonic development

The FASEB Journal, 2019
Nutrients are utilized and re‐constructed by endodermal epithelial cells (EECs) of yolk sac membrane (YSM) in avian species during embryonic development.
H. Lin, S. Ding
semanticscholar   +1 more source