Results 131 to 140 of about 19,805 (217)

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Nature Communications
Immune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu   +13 more
doaj   +1 more source

Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice*s⃞

Journal of Lipid Research, 2009
To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL) levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice, originally reported to have elevated HDL levels, to C57BL/6 mice and ...
Zhiguang Su, Xiaosong Wang, Shirng-Wern Tsaih, Aihong Zhang, Allison Cox, Susan Sheehan, Beverly Paigen   +6 more
doaj   +1 more source

SOAT1 exacerbates tumor progression by promoting YAP signaling activation and attenuating endoplasmic reticulum stress

View
Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang, Qianyu Li, Yifei Qian, Yu Tong, Songling Li, Wenyun Guo, Linfeng Li, Zijun Zhu, Wei‐Qiang Gao, Yanfeng Liu   +9 more
doaj   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes [PDF]

, 2020
BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders.
Davidson, Nicholas O, et al,, Meroni, Marica   +2 more
core   +1 more source

Penthorum chinense Pursh extract ameliorates alcohol-related fatty liver disease in mice via the SIRT1/AMPK signaling axis

Heliyon
Penthorum chinense Pursh (P. chinense), a functional food, has been applied to protect the liver against alcohol-related fatty liver disease (ALD) for a long history in China.
Hui Zhuge, Yan Pan, Shanglei Lai, Kaixin Chang, Qinchao Ding, Wenjing Cao, Qing Song, Songtao Li, Xiaobing Dou, Bin Ding   +9 more
doaj   +1 more source

Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: implications for diabetic dyslipidaemia and steatosis [PDF]

, 2014
Caridis, Anna-Maria, Dolan, Sharron, Graham, Annette, Soffientini, Ugo   +3 more
core   +1 more source

Structure of nevanimibe-bound tetrameric human ACAT1. [PDF]

Nature, 2020
Long T, Sun Y, Hassan A, Qi X, Li X.
europepmc   +1 more source

Cholesterol, Bile Acid, And Lipoprotein Metabolism In Two Strains Of Hamster, One Resistant, The Other Sensitive (LPN) To Sucrose-Induced Cholelithiasis [PDF]

, 2000
A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet.
Blanchard, Geraldine, Boehler, Nathalie, Combettes-Souverain, Murielle, Eckhardt, Erik, Ferezou, Jacqueline, Lutton, Claude, Milliat, Fabien, Riottot, Michel, Serougne, Colette, Smith, Jeffery L., Souidi, Maamar   +10 more
core  

Sterol O‐acyltransferase 1 enhances cholesterol esterification via cyclic AMP‐dependent pathway in the yolk sac membrane endodermal epithelial cells

, 2017
Han‐Jen Lin, S.-M. Wang, Yu‐Jen Chen, Harry J. Mersmann, Shih‐Torng Ding   +4 more
openalex   +1 more source