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The Journal of Antibiotics
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR.
Elyza Aiman Azizah Nur +5 more
semanticscholar +3 more sources
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR.
Elyza Aiman Azizah Nur +5 more
semanticscholar +3 more sources
Bioorganic & Medicinal Chemistry Letters, 2018
Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data.
M. M. Kapojos +9 more
semanticscholar +4 more sources
Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data.
M. M. Kapojos +9 more
semanticscholar +4 more sources
The Role of Sterol O-acyltransferase 1 In Obesity And In Prostate Cancer
2023ABSTRACT The worldwide obesity prevalence has almost tripled since 1973 according to the World Health Organization. In the United States, the disease is especially prevalent, with a recorded prevalence of 41.9 percent in 2017, as reported by the National Health and Nutrition Examination Survey.
openaire +1 more source
Cancer Research, 2022
Prostate cancer (PCa) growth is mediated by androgens via activation of androgen receptor (AR). Accordingly, androgen deprivation therapy (ADT) is the gold standard for the treatment of advanced PCa, but progression to castration-resistant PCa (CRPC ...
Sora Q. Kim +3 more
semanticscholar +1 more source
Prostate cancer (PCa) growth is mediated by androgens via activation of androgen receptor (AR). Accordingly, androgen deprivation therapy (ADT) is the gold standard for the treatment of advanced PCa, but progression to castration-resistant PCa (CRPC ...
Sora Q. Kim +3 more
semanticscholar +1 more source
Organic Letters
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. Heterologous expression of hvm in A.
Rui Wang +9 more
semanticscholar +1 more source
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. Heterologous expression of hvm in A.
Rui Wang +9 more
semanticscholar +1 more source
The FASEB Journal, 2019
Nutrients are utilized and re‐constructed by endodermal epithelial cells (EECs) of yolk sac membrane (YSM) in avian species during embryonic development.
H. Lin, S. Ding
semanticscholar +1 more source
Nutrients are utilized and re‐constructed by endodermal epithelial cells (EECs) of yolk sac membrane (YSM) in avian species during embryonic development.
H. Lin, S. Ding
semanticscholar +1 more source
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal
Nature, 2023Corinne P Soutar +2 more
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