Results 11 to 20 of about 12,786 (155)

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss. [PDF]

Lipids, 2016
AbstractStatin drugs have proven a successful and relatively safe therapy for the treatment of atherosclerotic cardiovascular disease (CVD). However, even with the substantial low‐density lipoprotein (LDL) cholesterol lowering achieved with statin treatment, CVD remains the top cause of death in developed countries.
Warrier M, Zhang J, Bura K, Kelley K, Wilson MD, Rudel LL, Brown JM.   +6 more
europepmc   +5 more sources

Sterol O-Acyltransferase 1 (<i>SOAT1</i>): A Genetic Modifier of Niemann-Pick Disease, Type C1. [PDF]

Int J Mol Sci
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a significant effect of modifier genes.
Farhat NY, Alexander D, McKee K, Iben J, Rodriguez-Gil JL, Wassif CA, Cawley NX, Balch WE, Porter FD.   +8 more
europepmc   +3 more sources

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. [PDF]

Nat Commun, 2020
AbstractSterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage. SOAT1 is a target to treat several human diseases.
Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L.   +9 more
europepmc   +6 more sources

New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440. [PDF]

Molecules, 2020
New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various spectroscopic experiments including 1D- and 2D-NMR.
Nur EAA, Kobayashi K, Amagai A, Ohshiro T, Tomoda H.   +4 more
europepmc   +6 more sources

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids. [PDF]

Commun Biol
AbstractViruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis.
Schöbel A, Pinho Dos Reis V, Burkhard R, Hehner J, Schneider L, Schauflinger M, Vieyres G, Herker E.   +7 more
europepmc   +4 more sources

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion. [PDF]

PLoS One, 2014
The primary risk factor for atherosclerotic cardiovascular disease is LDL cholesterol, which can be reduced by increasing cholesterol excretion from the body. Fecal cholesterol excretion can be driven by a hepatobiliary as well as a non-biliary pathway known as transintestinal cholesterol efflux (TICE).
Marshall SM, Gromovsky AD, Kelley KL, Davis MA, Wilson MD, Lee RG, Crooke RM, Graham MJ, Rudel LL, Brown JM, Temel RE.   +10 more
europepmc   +6 more sources

Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal [PDF]

Endocrine Reviews, 2014
Context: Steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) is a master regulator of adrenal development and steroidogenesis. Defects in several known targets of SF-1 can cause adrenal disorders in humans.Objective: We aimed to identify novel targets of SF-1 in
Achermann, JC, Dattani, MT, Ferraz-de-Souza, B, Hubank, M, Hudson-Davies, RE, Lin, L, Parnaik, R   +6 more
core   +9 more sources

Activation of Human Stearoyl-Coenzyme A Desaturase 1 Contributes to the Lipogenic Effect of PXR in HepG2 Cells [PDF]

, 2013
The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined.
A Moreau, B Zhang, BA Laffitte, Bingfang Hu, C Handschin, DJ Peet, EA Podrez, G Liang, GD Barish, H Shimano, HJ Kim, J Berger, J Zhou, J Zhou, JJ Repa, JJ Repa, JM Ntambi, JM Ntambi, JM Peters, JR Schultz, Jun Zhang, K Chu, K Nakamura, M Febbraio, M Miyazaki, Makoto Makishima, MC Sugden, Min Huang, O Gavrilova, P Georgel, P Tontonoz, S Kersten, S Yu, SB Joseph, SP Saini, W Jiang, W Samuel, W Xie, Wen Xie, X Feng, Y Barak, Y Zhai, Y Zhang, Yijuan Wei, Yonggong Zhai, YX Wang   +45 more
core   +8 more sources

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor [PDF]

, 2020
AbstractSterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family1. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage2. SOAT1 is a target to treat several human diseases3.
Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei   +9 more
openaire   +2 more sources

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source