Sterol O-Acyltransferase 1 (<i>SOAT1</i>): A Genetic Modifier of Niemann-Pick Disease, Type C1. [PDF]
Int J Mol SciNiemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment.. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a ...
Farhat NY +8 more
europepmc +6 more sources
Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome. [PDF]
Kidney Int, 2020 Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome.
Liu X +16 more
europepmc +7 more sources
Sterol O-Acyltransferase Inhibition Ameliorates High-Fat Diet-Induced Renal Fibrosis and Tertiary Lymphoid Tissue Maturation after Ischemic Reperfusion Injury. [PDF]
Int J Mol Sci, 2022 Metabolic syndrome is associated with the development of chronic kidney disease (CKD). We previously demonstrated that aged kidneys are prone to developing tertiary lymphoid tissues (TLTs) and sustain inflammation after injury, leading to CKD progression;
Ariyasu Y +5 more
europepmc +4 more sources
Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss. [PDF]
Lipids, 2016 AbstractStatin drugs have proven a successful and relatively safe therapy for the treatment of atherosclerotic cardiovascular disease (CVD). However, even with the substantial low‐density lipoprotein (LDL) cholesterol lowering achieved with statin treatment, CVD remains the top cause of death in developed countries.
Warrier M +6 more
europepmc +7 more sources
Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor [PDF]
bioRxiv, 2020 Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family 1.
Chengcheng Guan +9 more
semanticscholar +4 more sources
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function. [PDF]
Am J Physiol Gastrointest Liver Physiol, 2018 Cholesteryl esters are generated at multiple sites in the body by sterol O-acyltransferase (SOAT) 1 or SOAT2 in various cell types and lecithin cholesterol acyltransferase in plasma.
Lopez AM, Jones RD, Repa JJ, Turley SD.
europepmc +3 more sources
Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsObjective Excess unesterified (free) cholesterol can induce formation of cholesterol crystals in hepatocyte lipid droplets. Presence of such crystal distinguishes metabolic dysfunction associated steatohepatitis (MASH) from simple steatosis and may ...
Jordan A. Bairos +7 more
semanticscholar +5 more sources
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2. [PDF]
J Lipid Res, 2014 Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2.
Pramfalk C +5 more
europepmc +7 more sources
Biosynthesis of Phytosterol Esters: Identification of a Sterol O-Acyltransferase in Arabidopsis [PDF]
Plant Physiology, 2007 Fatty acyl esters of phytosterols are a major form of sterol conjugates distributed in many parts of plants. In this study we report an Arabidopsis (Arabidopsis thaliana) gene, AtSAT1 (At3g51970), which encodes for a novel sterol O-acyltransferase.
Qilin Chen +4 more
semanticscholar +6 more sources
Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal [PDF]
Endocrine Reviews, 2011 We used up- and down-regulation of the nuclear receptor steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) to identify new components of adrenal function and steroidogenesis.
Bruno Ferraz‐de‐Souza +6 more
semanticscholar +10 more sources