Results 11 to 20 of about 14,545 (218)

Sterol O-Acyltransferase Inhibition Ameliorates High-Fat Diet-Induced Renal Fibrosis and Tertiary Lymphoid Tissue Maturation after Ischemic Reperfusion Injury. [PDF]

Int J Mol Sci, 2022
Metabolic syndrome is associated with the development of chronic kidney disease (CKD). We previously demonstrated that aged kidneys are prone to developing tertiary lymphoid tissues (TLTs) and sustain inflammation after injury, leading to CKD progression; however, the relationship between renal TLT and metabolic syndrome is unknown.
Ariyasu Y, Sato Y, Isobe Y, Taniguchi K, Yanagita M, Arita M.   +5 more
europepmc   +5 more sources

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss. [PDF]

Lipids, 2016
AbstractStatin drugs have proven a successful and relatively safe therapy for the treatment of atherosclerotic cardiovascular disease (CVD). However, even with the substantial low‐density lipoprotein (LDL) cholesterol lowering achieved with statin treatment, CVD remains the top cause of death in developed countries.
Warrier M, Zhang J, Bura K, Kelley K, Wilson MD, Rudel LL, Brown JM.   +6 more
europepmc   +6 more sources

Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186. [PDF]

Appl Environ Microbiol, 2023
ABSTRACT Thraustochytrids are marine microorganisms expected to produce useful lipids. They synthesize polyunsaturated fatty acids and sterols and store them in lipid droplets as a form of triacylglycerol (TG) and sterol ester (SE), respectively. TG is synthesized by diacylglycerol O -acyltransferase (DGAT)
Ishibashi Y, Sadamitsu S, Fukahori Y, Yamamoto Y, Tanogashira R, Watanabe T, Hayashi M, Ito M, Okino N.   +8 more
europepmc   +4 more sources

Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. [PDF]

Exp Mol Pathol, 2015
The cholesterol-metabolizing enzyme sterol O-acetyltransferase (SOAT1) is implicated in an increasing number of biological and pathological processes in a number of organ systems, including the differentiation of the hair shaft. While the functional and regulatory mechanisms underlying these diverse functional roles remain poorly understood, the ...
Potter CS, Kern MJ, Baybo MA, Pruett ND, Godwin AR, Sundberg JP, Awgulewitsch A.   +6 more
europepmc   +7 more sources

Comprehensive prognostic and immune analysis of sterol O-acyltransferase 1 in patients with hepatocellular carcinoma. [PDF]

World J Hepatol
BACKGROUND Sterol O-acyltransferase 1 (SOAT1) is an important target in the diagnosis and treatment of liver cancer. However, the prognostic value of SOAT1 in patients with hepatocellular carcinoma (HCC) is still not clear. AIM To investigate the correlation of SOAT1 expression with HCC, using RNA-seq and gene expression ...
Gan CJ, Zheng Y, Yang B, Cao LM.
europepmc   +4 more sources

Sterol O-Acyltransferase 1 (<i>SOAT1</i>): A Genetic Modifier of Niemann-Pick Disease, Type C1. [PDF]

Int J Mol Sci
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a significant effect of modifier genes.
Farhat NY, Alexander D, McKee K, Iben J, Rodriguez-Gil JL, Wassif CA, Cawley NX, Balch WE, Porter FD.   +8 more
europepmc   +5 more sources

Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome. [PDF]

Kidney Int, 2020
Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome.
Liu X, Ducasa GM, Mallela SK, Kim JJ, Molina J, Mitrofanova A, Wilbon SS, Ge M, Fontanella A, Pedigo C, Santos JV, Nelson RG, Drexler Y, Contreras G, Al-Ali H, Merscher S, Fornoni A.   +16 more
europepmc   +6 more sources

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis

Chinese Journal of Physiology, 2023
Recently, evidence has shown that microRNA-100-3p (miR-100-3p) has been revealed as a tumor suppressor in diverse human diseases, while its capability in lung cancer warrants further validation. In this work, we aimed to discuss the impact of sevoflurane
Bicheng Fu, Fucheng Zhou, Jian Zhang, Xianglong Kong, Boxiong Ni, Jianlong Bu, Shidong Xu, Changjun He   +7 more
doaj   +4 more sources

Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation [PDF]

Lipids in Health and Disease, 2012
Background Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown.
Schmidt Simone, Willers Janina, Stahl Frank, Mutz Kai-Oliver, Scheper Thomas, Hahn Andreas, Schuchardt Jan Philipp   +6 more
doaj   +4 more sources

Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307 [PDF]

The Journal of Antibiotics, 2018
New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR.
Taichi Ohshiro, Reiko Seki, Takashi Fukuda, Ryuji Uchida, Hiroshi Tomoda   +4 more
openalex   +3 more sources