Results 11 to 20 of about 13,985 (173)

Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186. [PDF]

Appl Environ Microbiol, 2023
Thraustochytrids are marine microorganisms expected to produce useful lipids. They synthesize polyunsaturated fatty acids and sterols and store them in lipid droplets as a form of triacylglycerol (TG) and sterol ester (SE), respectively.
Ishibashi Y, Sadamitsu S, Fukahori Y, Yamamoto Y, Tanogashira R, Watanabe T, Hayashi M, Ito M, Okino N.   +8 more
europepmc   +4 more sources

Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome. [PDF]

Kidney Int, 2020
Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome ...
Liu X, Ducasa GM, Mallela SK, Kim JJ, Molina J, Mitrofanova A, Wilbon SS, Ge M, Fontanella A, Pedigo C, Santos JV, Nelson RG, Drexler Y, Contreras G, Al-Ali H, Merscher S, Fornoni A.   +16 more
europepmc   +5 more sources

Sterol O-Acyltransferase 1 (<i>SOAT1</i>): A Genetic Modifier of Niemann-Pick Disease, Type C1. [PDF]

Int J Mol Sci
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment.. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a ...
Farhat NY, Alexander D, McKee K, Iben J, Rodriguez-Gil JL, Wassif CA, Cawley NX, Balch WE, Porter FD.   +8 more
europepmc   +4 more sources

Sterol O-Acyltransferase Inhibition Ameliorates High-Fat Diet-Induced Renal Fibrosis and Tertiary Lymphoid Tissue Maturation after Ischemic Reperfusion Injury. [PDF]

Int J Mol Sci, 2022
Metabolic syndrome is associated with the development of chronic kidney disease (CKD). We previously demonstrated that aged kidneys are prone to developing tertiary lymphoid tissues (TLTs) and sustain inflammation after injury, leading to CKD progression;
Ariyasu Y, Sato Y, Isobe Y, Taniguchi K, Yanagita M, Arita M.   +5 more
europepmc   +4 more sources

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis

Chinese Journal of Physiology, 2023
Recently, evidence has shown that microRNA-100-3p (miR-100-3p) has been revealed as a tumor suppressor in diverse human diseases, while its capability in lung cancer warrants further validation. In this work, we aimed to discuss the impact of sevoflurane
Bicheng Fu, Fucheng Zhou, Jian Zhang, Xianglong Kong, Boxiong Ni, Jianlong Bu, Shidong Xu, Changjun He   +7 more
doaj   +4 more sources

Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss. [PDF]

Lipids, 2016
AbstractStatin drugs have proven a successful and relatively safe therapy for the treatment of atherosclerotic cardiovascular disease (CVD). However, even with the substantial low‐density lipoprotein (LDL) cholesterol lowering achieved with statin treatment, CVD remains the top cause of death in developed countries.
Warrier M, Zhang J, Bura K, Kelley K, Wilson MD, Rudel LL, Brown JM.   +6 more
europepmc   +5 more sources

Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. [PDF]

Exp Mol Pathol, 2015
The cholesterol-metabolizing enzyme sterol O-acetyltransferase (SOAT1) is implicated in an increasing number of biological and pathological processes in a number of organ systems, including the differentiation of the hair shaft. While the functional and regulatory mechanisms underlying these diverse functional roles remain poorly understood, the ...
Potter CS, Kern MJ, Baybo MA, Pruett ND, Godwin AR, Sundberg JP, Awgulewitsch A.   +6 more
europepmc   +6 more sources

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor [PDF]

bioRxiv, 2020
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family 1.
C. Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, K. Nishi, C. Chang, Ta-Yuan Chang, T. Luo, Lei Chen   +9 more
semanticscholar   +2 more sources

Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function.

Am J Physiol Gastrointest Liver Physiol, 2018
Cholesteryl esters are generated at multiple sites in the body by sterol O-acyltransferase (SOAT) 1 or SOAT2 in various cell types and lecithin cholesterol acyltransferase in plasma.
Lopez AM, Jones RD, Repa JJ, Turley SD.
europepmc   +2 more sources

Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Objective Excess unesterified (free) cholesterol can induce formation of cholesterol crystals in hepatocyte lipid droplets. Presence of such crystal distinguishes metabolic dysfunction associated steatohepatitis (MASH) from simple steatosis and may ...
Jordan A Bairos, Uche Njoku, Maria Zafar, May G. Akl, Lei Li, Gunes Parlakgul, A. P. Arruda, Scott B. Widenmaier   +7 more
semanticscholar   +3 more sources