Results 21 to 30 of about 12,786 (155)

Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131 [PDF]

The Journal of Antibiotics, 2015
A new compound designated as clonoamide was isolated from a culture broth of the fungus Clonostachys sp. BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor of sterol O-acyltransferase (SOAT). The structure of clonoamide was elucidated as 2-oxo-9E,11E-tridecandienyl
Hiroshi Tomoda, Nobuaki Tsukasaki, Yuichi Yamaguchi, Yuichi Yamaguchi, Ryuji Uchida, Keisuke Kobayashi   +5 more
openaire   +2 more sources

Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]

, 2018
Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia, Morales, Diego, Soler-Rivas, Cristina   +2 more
core   +1 more source

The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding [PDF]

, 2013
BACKGROUND: High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase ...
Bradley S Henriksen, Brandon R Cardon, Chad R Hancock, David M Thomson, Mary E Curtis, Natasha Fillmore   +5 more
core   +1 more source

Expression of fatty acid and lipid biosynthetic genes in developing endosperm of Jatropha curcas [PDF]

, 2012
BACKGROUND: Temporal and spatial expression of fatty acid and lipid biosynthetic genes are associated with the accumulation of storage lipids in the seeds of oil plants.
Chengxin Yi, Dongsheng Tian, Jatinder Sangha, Keyu Gu, Yan Hong, Zhongchao Yin   +5 more
core   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation [PDF]

, 2012
Background: Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown. The aim of this study
Hahn, Andreas, Mutz, Kai-Oliver, Scheper, Thomas, Schmidt, Simone, Schuchardt, Jan Philipp, Stahl, Frank, Willers, Janina   +6 more
core   +1 more source

Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16 [PDF]

The Journal of Antibiotics, 2015
Diketopiperazines, inhibitors of sterol O -acyltransferase, produced by a marine-derived Nocardiopsis sp.
Takeshi Terahara, Chiaki Imada, Hiroshi Tomoda, Enjuro Harunari, Takashi Fukuda, Keisuke Kobayashi   +5 more
openaire   +2 more sources

The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease [PDF]

, 2015
Background Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production and de novo lipogenesis. Persistent organic pollutants (POPs)
Caroline Lefebvre, Marie-Pier Boucher, Natalie Ann Chapados   +2 more
core   +1 more source

Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds [PDF]

, 2009
In higher plants, the most abundant sterol derivatives are steryl glycosides (SGs) and acyl SGs. Arabidopsis (Arabidopsis thaliana) contains two genes, UGT80A2 and UGT80B1, that encode UDP-Glc:sterol glycosyltransferases, enzymes that catalyze the ...
Auer, Manfred, Beisson, Fred, Bischoff, Volker, Bouvier-Navé, Pierrette, Carroll, Andrew, DeBolt, Seth, Hematy, Kian, Li, Yonghua, Milne, Jennifer, Nair, Meera, Schaller, Hubert, Scheible, Wolf-Rüdiger, Schrick, Kathrin, Somerville, Chris, Zemla, Marcin   +14 more
core   +5 more sources

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines [PDF]

, 2006
Objective - Although inflammation is a recognized feature of atherosclerosis, the impact of inflammation on cellular cholesterol homeostasis is unclear.
Ma, KL, Moorhead, JF, Powis, SH, Ruan, XZ, Tao, JL, Varghese, Z, Wheeler, DC   +6 more
core   +1 more source