Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. [PDF]
J Invest Dermatol, 2010 Wu B +9 more
europepmc +6 more sources
Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal [PDF]
, 2014 Context: Steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) is a master regulator of adrenal development and steroidogenesis. Defects in several known targets of SF-1 can cause adrenal disorders in humans.Objective: We aimed to identify novel targets of SF-1 in
Achermann, JC +6 more
core +4 more sources
Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor [PDF]
, 2020 AbstractSterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family1. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage2. SOAT1 is a target to treat several human diseases3.
Chengcheng Guan +9 more
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Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsABSTRACTObjectiveExcess unesterified (free) cholesterol can induce formation of cholesterol crystals in hepatocyte lipid droplets. Presence of such crystal distinguishes metabolic dysfunction associated steatohepatitis (MASH) from simple steatosis and may underlie its pathogenesis by causing cell damage that triggers liver inflammation.
Jordan A. Bairos +7 more
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7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007 [PDF]
The Journal of Antibiotics, 2016 A new depsidone, named 7-chlorofolipastatin, and five known structurally related depsidones were isolated from the culture broth of the marine-derived fungus Aspergillus ungui NKM-007 by solvent extraction and HPLC using an octadecylsilyl column. The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR ...
Ryuji Uchida +6 more
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Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131 [PDF]
The Journal of Antibiotics, 2015 A new compound designated as clonoamide was isolated from a culture broth of the fungus Clonostachys sp. BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor of sterol O-acyltransferase (SOAT). The structure of clonoamide was elucidated as 2-oxo-9E,11E-tridecandienyl
Keisuke Kobayashi +4 more
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Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16 [PDF]
The Journal of Antibiotics, 2015 Diketopiperazines, inhibitors of sterol O -acyltransferase, produced by a marine-derived Nocardiopsis sp.
Keisuke Kobayashi +5 more
openalex +3 more sources
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function. [PDF]
Am J Physiol Gastrointest Liver Physiol, 2018 Lopez AM, Jones RD, Repa JJ, Turley SD.
europepmc +2 more sources
HepatologyBackground and Aims: The development of hepatocellular carcinoma (HCC) is intricately linked to metabolic processes and immune evasion strategies. As an emerging metabolic vulnerability in HCC, the detailed molecular mechanisms of sterol O-acyltransferase 1 (SOAT1) and its role in immune regulation remain ...
Huanhuan Ma +12 more
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Bioorganic & Medicinal Chemistry Letters, 2018 Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data.
Magie M. Kapojos +9 more
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