PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice. [PDF]
J Pharmacol Exp Ther, 2015 Lopez AM +6 more
europepmc +3 more sources
Sterol O-acyltransferase 1 (SOAT1; ACAT1) [PDF]
Science-Business eXchange, 2010 openalex +3 more sources
Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2. [PDF]
Circ Res, 2014 Zhang J +7 more
europepmc +2 more sources
Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion [PDF]
Breast Cancer ResearchSignaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells.
Jennifer E. Tuokkola +6 more
doaj +2 more sources
N4-acetylcytidine-mediated SOAT1 upregulation aggravates heart failure by inducing NCOA4-dependent ferroautophagy and ferroptosis in cardiomyocytes [PDF]
Cellular and Molecular Life SciencesHeart failure (HF) remains a critical global health challenge, with accumulating evidence implicating iron metabolism dysregulation through ferritinophagy activation in disease progression.
Jizhao Deng, Xiting Nong, Guang Yang
doaj +2 more sources
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. [PDF]
Biochem Biophys Res Commun, 2014 Lopez AM, Posey KS, Turley SD.
europepmc +2 more sources
Screening and functional validation of lipid metabolism-related lncRNA-46546 based on the transcriptome analysis of early embryonic muscle tissue in chicken [PDF]
Animal Bioscience, 2023 Objective The study was conducted to screen differentially expressed long noncoding RNA (lncRNA) in chickens by high-throughput sequencing and explore its mechanism of action on intramuscular fat deposition.
Ruonan Chen +5 more
doaj +1 more source
Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
Biomedicines, 2022 Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol ...
Yongjun Kou, Feng Geng, Deliang Guo
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Frontiers in Plant Science, 2022 Triterpenoids exist in a free state and/or in conjugated states, such as triterpene glycosides (saponins) or triterpene esters. There is no information on the enzyme participating in the production of triterpene esters from free triterpenes.
Han Suk Choi +3 more
doaj +1 more source
Metabolites, 2021 The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest in cholesterol metabolism given their profound effects on foam cell biology and
Qimin Hai, Jonathan D. Smith
doaj +1 more source