Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16 [PDF]
The Journal of Antibiotics, 2015 Diketopiperazines, inhibitors of sterol O -acyltransferase, produced by a marine-derived Nocardiopsis sp.
Keisuke Kobayashi +5 more
semanticscholar +4 more sources
Biological and Pharmaceutical Bulletin, 2020 The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse models via inhibiting sterol O-acyltransferase (SOAT) activity.
Taichi Ohshiro +7 more
openalex +3 more sources
Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFβ pathway in endodermal epithelial cells of Japanese quail [PDF]
bioRxiv, 2019 Nutrients are utilized and re-constructed by endodermal epithelial cells (EECs) in yolk sac membranes in avian species. Sterol-O acyltransferase 1 (SOAT1) is the key enzyme to convert cholesterol to cholesteryl ester for delivery to growing embryos ...
Han‐Jen Lin +3 more
semanticscholar +3 more sources
Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion [PDF]
Breast Cancer ResearchSignaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells.
Jennifer E. Tuokkola +6 more
doaj +2 more sources
ACAT1/SOAT1 maintains adipogenic ability in preadipocytes by regulating cholesterol homeostasis [PDF]
Journal of Lipid ResearchMaintaining cholesterol homeostasis is critical for preserving adipocyte function during the progression of obesity. Despite this, the regulatory role of cholesterol esterification in governing adipocyte expandability has been understudied. Acyl-coenzyme
Qing Liu +9 more
doaj +2 more sources
TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway [PDF]
Annals of MedicineBackground tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies.
Qianyi Qi +8 more
doaj +2 more sources
Sterol O-acyltransferase 1 (SOAT1; ACAT1) [PDF]
Science-Business eXchange, 2010 openalex +3 more sources
HepatologyBACKGROUND AND AIMS The development of hepatocellular carcinoma (HCC) is intricately linked to metabolic processes and immune evasion strategies. As an emerging metabolic vulnerability in HCC, detailed molecular mechanisms of Sterol O-Acyltransferase 1 ...
Huanhuan Ma +12 more
openalex +2 more sources
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. [PDF]
Biochem Biophys Res Commun, 2014 Lopez AM, Posey KS, Turley SD.
europepmc +3 more sources
Screening and functional validation of lipid metabolism-related lncRNA-46546 based on the transcriptome analysis of early embryonic muscle tissue in chicken [PDF]
Animal Bioscience, 2023 Objective The study was conducted to screen differentially expressed long noncoding RNA (lncRNA) in chickens by high-throughput sequencing and explore its mechanism of action on intramuscular fat deposition.
Ruonan Chen +5 more
doaj +1 more source