Biological and Pharmaceutical Bulletin, 2020 The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse models via inhibiting sterol O-acyltransferase (SOAT) activity.
Taichi Ohshiro +7 more
openalex +3 more sources
Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFβ pathway in endodermal epithelial cells of Japanese quail [PDF]
bioRxiv, 2019 Nutrients are utilized and re-constructed by endodermal epithelial cells (EECs) in yolk sac membranes in avian species. Sterol-O acyltransferase 1 (SOAT1) is the key enzyme to convert cholesterol to cholesteryl ester for delivery to growing embryos ...
Han‐Jen Lin +3 more
semanticscholar +3 more sources
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]
Journal of Lipid Research, 2014 Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance.
Camilla Pramfalk +5 more
doaj +2 more sources
ACAT1/SOAT1 maintains adipogenic ability in preadipocytes by regulating cholesterol homeostasis [PDF]
Journal of Lipid ResearchMaintaining cholesterol homeostasis is critical for preserving adipocyte function during the progression of obesity. Despite this, the regulatory role of cholesterol esterification in governing adipocyte expandability has been understudied. Acyl-coenzyme
Qing Liu +9 more
doaj +2 more sources
TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway [PDF]
Annals of MedicineBackground tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies.
Qianyi Qi +8 more
doaj +2 more sources
Sterol O-acyltransferase 1 (SOAT1; ACAT1) [PDF]
Science-Business eXchange, 2010 openalex +3 more sources
Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice [PDF]
Journal of Investigative Dermatology, 2010 Baojin Wu +9 more
openalex +4 more sources
Screening and functional validation of lipid metabolism-related lncRNA-46546 based on the transcriptome analysis of early embryonic muscle tissue in chicken [PDF]
Animal Bioscience, 2023 Objective The study was conducted to screen differentially expressed long noncoding RNA (lncRNA) in chickens by high-throughput sequencing and explore its mechanism of action on intramuscular fat deposition.
Ruonan Chen +5 more
doaj +1 more source
Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
Biomedicines, 2022 Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol ...
Yongjun Kou, Feng Geng, Deliang Guo
doaj +1 more source
Frontiers in Plant Science, 2022 Triterpenoids exist in a free state and/or in conjugated states, such as triterpene glycosides (saponins) or triterpene esters. There is no information on the enzyme participating in the production of triterpene esters from free triterpenes.
Han Suk Choi +3 more
doaj +1 more source