Metabolites, 2021 The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest in cholesterol metabolism given their profound effects on foam cell biology and
Qimin Hai, Jonathan D. Smith
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The Journal of Antibiotics, 2018 New indanones, designated celludinones A ((±)-1) and B (2), were isolated from the culture broth of the fungal strain Talaromyces cellulolyticus BF-0307. The structures of celludinones were elucidated by spectroscopic data, including 1D and 2D NMR.
Taichi Ohshiro +4 more
semanticscholar +3 more sources
Biomolecules, 2021 The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T)
Lengyun Wei +4 more
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Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. [PDF]
Biochem Biophys Res Commun, 2014 Lopez AM, Posey KS, Turley SD.
europepmc +2 more sources
7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007 [PDF]
The Journal of Antibiotics, 2016 A new depsidone, named 7-chlorofolipastatin, and five known structurally related depsidones were isolated from the culture broth of the marine-derived fungus Aspergillus ungui NKM-007 by solvent extraction and HPLC using an octadecylsilyl column. The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR ...
R. Uchida +6 more
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Clonoamide, a new inhibitor of sterol O-acyltransferase, produced by Clonostachys sp. BF-0131 [PDF]
The Journal of Antibiotics, 2015 A new compound designated as clonoamide was isolated from a culture broth of the fungus Clonostachys sp. BF-0131 by solvent extraction, Diaion HP20 column chromatography, octadecylsilyl column chromatography and preparative HPLC as an inhibitor of sterol O-acyltransferase (SOAT). The structure of clonoamide was elucidated as 2-oxo-9E,11E-tridecandienyl
Keisuke Kobayashi +4 more
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Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16 [PDF]
The Journal of Antibiotics, 2015 Diketopiperazines, inhibitors of sterol O -acyltransferase, produced by a marine-derived Nocardiopsis sp.
Keisuke Kobayashi +5 more
semanticscholar +3 more sources
Beta-Ketothiolase Deficiency: A Comprehensive Review of Genetic Variants and Pathophysiology [PDF]
Annals of Child NeurologyBeta-ketothiolase deficiency (BKD) is a rare autosomal recessive disorder caused by mutations in the ACAT1 gene, also known as mitochondrial acetoacetyl-coenzyme A thiolase (MAT) deficiency.
Sohit Kashyap +5 more
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Cholesterol esterification and p53-mediated tumor suppression
Exploration of Targeted Anti-tumor Therapy, 2023 Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintenance of
Youjun Li +2 more
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Peroral administration of beauverolides allows their transport into the peripheral blood and urine
CyTA - Journal of Food, 2020 Beauverolides are hydrophobic cyclodepsipeptides that inhibit sterol O-acyltransferases and calmodulin, thereby reducing senile plaques in Alzheimer’s disease and preventing foam cell formation in atherosclerosis.
Petr Heneberg +2 more
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