Results 41 to 50 of about 13,985 (173)

Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans

Journal of Lipid Research, 2022
: Mutations in the LCAT gene cause familial LCAT deficiency (Online Mendelian Inheritance in Man ID: #245900), a very rare metabolic disorder. LCAT is the only enzyme able to esterify cholesterol in plasma, whereas sterol O-acyltransferases 1 and 2 are ...
Chiara Pavanello, Alice Ossoli, Arianna Strazzella, Patrizia Risè, Fabrizio Veglia, Marie Lhomme, Paolo Parini, Laura Calabresi   +7 more
doaj   +1 more source

Identification and Characterization of Genes Involved in Ecdysteroid Esterification Pathway Contributing to the High 20-Hydroxyecdysone Resistance of Helicoverpa armigera

Frontiers in Physiology, 2020
20-Hydroxyecdysone (20E), the most important regulator for insect development, is also a major component in phytoecdysteroids in plants. Therefore, this plant-derived hormone is considered as a potential natural product for use in pest management ...
Hengtong Duan, Xin Yang, Zhanyao Bu, Xinyue Li, Ze Zhang, Wei Sun   +5 more
doaj   +1 more source

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis

Frontiers in Pharmacology, 2021
Emerging evidences demonstrate that metabolic reprogramming is a hallmark of malignancies, including gastric cancer (GC). Abnormal expression of metabolic rate-limiting enzymes, as the executive medium of energy metabolism, drives the occurrence and ...
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Shouyu Wang, Shouyu Wang, Qingqing Ding, Guifang Xu   +12 more
doaj   +1 more source

cAMP Response Element Binding Protein 1 (CREB1) Promotes Monounsaturated Fatty Acid Synthesis and Triacylglycerol Accumulation in Goat Mammary Epithelial Cells

Animals, 2020
cAMP response element binding protein 1 (CREB1) is a member of the leucine zipper transcription factor family of DNA binding proteins. Although studies in non-ruminants have demonstrated a crucial role of CREB1 in lipid synthesis in liver and adipose ...
Dawei Yao, Chunlei Yang, Jing Ma, Lili Chen, Jun Luo, Yi Ma, Juan. J. Loor   +6 more
doaj   +1 more source

Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation

Lipids in Health and Disease, 2012
Background Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown.
Schmidt Simone, Willers Janina, Stahl Frank, Mutz Kai-Oliver, Scheper Thomas, Hahn Andreas, Schuchardt Jan Philipp   +6 more
doaj   +1 more source

Dietary Supplementation of Baicalein Affects Gene Expression in Broiler Adipose Tissue During the First Week Post-hatch

Frontiers in Physiology, 2021
Dietary supplementation of baicalein, a flavonoid, has anti-obesity effects in mammals and broiler chickens. The aim of this study was to determine the effect of dietary baicalein supplementation on broiler growth and adipose tissue and breast muscle ...
Yang Xiao, Bailey Halter, Casey Boyer, Mark A. Cline, Dongmin Liu, Elizabeth R. Gilbert   +5 more
doaj   +1 more source

Mutations in sterol O-acyltransferase 1 (Soat1) result in hair interior defects in AKR/J mice. [PDF]

J Invest Dermatol, 2010
Wu B, Potter CS, Silva KA, Liang Y, Reinholdt LG, Alley LM, Rowe LB, Roopenian DC, Awgulewitsch A, Sundberg JP.   +9 more
europepmc   +4 more sources

The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice.

Biological and Pharmaceutical Bulletin, 2020
The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse models via inhibiting sterol O-acyltransferase (SOAT) activity.
Taichi Ohshiro, Satoshi Imuta, Ichiro Hijikuro, H. Yagyu, Takashi Takahashi, T. Doi, S. Ishibashi, H. Tomoda   +7 more
semanticscholar   +1 more source

Effect of APOB polymorphism rs562338 (G/A) on serum proteome of coronary artery disease patients: a “proteogenomic” approach

Scientific Reports, 2021
In the current study, APOB (rs1052031) genotype-guided proteomic analysis was performed in a cohort of Pakistani population. A total of 700 study subjects, including Coronary Artery Disease (CAD) patients (n = 480) and healthy individuals (n = 220) as a ...
Muneeza Zafar, Munazza Raza Mirza, Fazli Rabbi Awan, Muhammad Tahir, Rabia Sultan, Misbah Hussain, Ahmed Bilal, Shahid Abbas, Martin R. Larsen, Muhammad Iqbal Choudhary, Imran Riaz Malik   +10 more
doaj   +1 more source

Blocking cholesterol storage to treat Alzheimer’s disease

Exploration of Neuroprotective Therapy, 2021
Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions.
Ta Yuan Chang, Catherine C. Y. Chang, Taylor C. Harned, Adrianna L. De La Torre, Junghoon Lee, Thao N. Huynh, James G. Gow   +6 more
doaj   +1 more source