Results 41 to 50 of about 14,545 (218)

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells

Biomolecules, 2021
The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T)
Lengyun Wei, Xuyang Lu, Shengmei Weng, Shenglong Zhu, Yongquan Chen   +4 more
doaj   +1 more source

Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats [PDF]

, 2013
Peer reviewedPublisher ...
A Venkateswaran, Alberto Davalos, AO Odegaard, AS Greenberg, AV Khera, BA Janowski, C Zetina Moguel, CD Mathers, DE Kleiner, DJ Gordon, DP Mertz, ER Mojica, FR Van der Leij, G Grant, George Grant, GJ Miller, H Komano, H Leontowicz, HA Tyroler, HH Liu, Hirian Alonso Moshe Barrera-Perez, I Hawa, J Ayo, J Folch, J Lin, J Wen, JC Cohen, JC Cohen, JC Yoon, JD Horton, Jean-Marc A Lobaccaro, JJ Repa, Jorge Montero, Jorge Rubio-Piña, JR Schultz, JW Heinecke, JY Chiang, K Liu, KJ Livak, L Olivera, Leticia Olivera-Castillo, M Yahyavi, MC Damiani, MD Säemann, ME Rodríguez, MF Lopes-Virella, Miguel Angel Olvera-Novoa, N Hasegawa, N Torres, NE Miller, Nina Valadez-Gonzalez, P Araujo, P Lefebvre, Pablo Acereto-Escoffie, RG Herrmann, RK Semple, Roche Diagnostics, Rossanna Rodriguez-Canul, RR Sokal, S Acton, S Najwa, T Park, T Rajamohan, T Sugawara, VL Roger, Víctor Ceja-Moreno, X Duan, X Hu, XQ Hu, XQ Hu, Y Zhong, Yasser Chim-Chi, Z Hossain   +72 more
core   +8 more sources

Measurement of human sterol-o-acyltransferase 1, SOAT1 levels in Iraqi diabetic patients [PDF]

International Journal of Chemical and Biological Sciences
Hussein Najm Abed
openalex   +2 more sources

The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding [PDF]

, 2013
BACKGROUND: High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase ...
Bradley S Henriksen, Brandon R Cardon, Chad R Hancock, David M Thomson, Mary E Curtis, Natasha Fillmore   +5 more
core   +1 more source

Beta-Ketothiolase Deficiency: A Comprehensive Review of Genetic Variants and Pathophysiology [PDF]

Annals of Child Neurology
Beta-ketothiolase deficiency (BKD) is a rare autosomal recessive disorder caused by mutations in the ACAT1 gene, also known as mitochondrial acetoacetyl-coenzyme A thiolase (MAT) deficiency.
Sohit Kashyap, Anil Kumar, Anita Choudhary, Ajay Kumar, Arvinder Wander, Anjana Munshi   +5 more
doaj   +1 more source

Cholesterol esterification and p53-mediated tumor suppression

Exploration of Targeted Anti-tumor Therapy, 2023
Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintenance of
Youjun Li, Michael Karin, Edward V. Prochownik   +2 more
doaj   +1 more source

Peroral administration of beauverolides allows their transport into the peripheral blood and urine

CyTA - Journal of Food, 2020
Beauverolides are hydrophobic cyclodepsipeptides that inhibit sterol O-acyltransferases and calmodulin, thereby reducing senile plaques in Alzheimer’s disease and preventing foam cell formation in atherosclerosis.
Petr Heneberg, Alexandr Jegorov, Petr Šimek   +2 more
doaj   +1 more source

Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds [PDF]

, 2009
In higher plants, the most abundant sterol derivatives are steryl glycosides (SGs) and acyl SGs. Arabidopsis (Arabidopsis thaliana) contains two genes, UGT80A2 and UGT80B1, that encode UDP-Glc:sterol glycosyltransferases, enzymes that catalyze the ...
Auer, Manfred, Beisson, Fred, Bischoff, Volker, Bouvier-Navé, Pierrette, Carroll, Andrew, DeBolt, Seth, Hematy, Kian, Li, Yonghua, Milne, Jennifer, Nair, Meera, Schaller, Hubert, Scheible, Wolf-Rüdiger, Schrick, Kathrin, Somerville, Chris, Zemla, Marcin   +14 more
core   +5 more sources

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources