Results 41 to 50 of about 12,786 (155)

Cholesterol homeostasis: a key to prevent or slow down neurodegeneration [PDF]

, 2013
Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. Typically human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people ...
Anchisi L., Dessi S., Mandas A, Pani A.
core   +1 more source

Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation

Cancer Communications, EarlyView.
Abstract Background Hepatocellular carcinoma (HCC) is a deadly malignancy known for its ability to evade immune surveillance. NOP2/Sun RNA methyltransferase family member 2 (NSUN2), an RNA methyltransferase involved in carcinogenesis, has been associated with immune evasion and energy metabolism reprogramming.
Jinhua Jiang, Feng Liu, Dan Cui, Caixia Xu, Jiachang Chi, Tinghua Yan, Fang Guo   +6 more
wiley   +1 more source

Flagellar membrane association via interaction with lipid rafts [PDF]

, 2009
The eukaryotic flagellar membrane has a distinct composition from other domains of the plasmalemma. Our work shows that the specialized composition of the trypanosome flagellar membrane reflects increased concentrations of sterols and saturated fatty ...
Cieslak, John A., Engman, David M., Fridberg, Alina, Hazlett, Theodore L., Olson, Cheryl L., Torriela, Krista M., Tyler, Kevin M.   +6 more
core   +2 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Cancer therapy‐related cardiotoxicity is associated with distinct alterations of the myocardial lipidome

European Journal of Heart Failure, EarlyView.
Lipidome changes in anthracycline‐induced cardiotoxicity (AIC). Aims Anthracyclines are key components of various chemotherapy regimens, but their clinical utility is limited by severe cardiotoxic side effects. Previous studies have suggested that anthracycline‐induced cardiotoxicity (AIC) may be driven by alterations in myocardial lipid metabolism ...
Vera M. Braun, Anna Foryst‐Ludwig, Ulf Landmesser, István Baczkó, Hendrik Milting, Ulrich Kintscher, Niklas Beyhoff   +6 more
wiley   +1 more source

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]

, 2011
F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu, Iwasaki Hitoshi, Karasawa Tadayoshi, Kobayashi Kazuto, Kumadaki Shin, Matsuzaka Takashi, Nakagawa Yoshimi, Nakakuki Masanori, Saito Ryo, Shimano Hitoshi, Sone Hirohito, Suzuki Hiroaki, Takahashi Akimitsu, Takahashi Satoru, Takekoshi Kazuhiro, Yahagi Naoya, Yamada Nobuhiro, Yatoh Shigeru, 中川 嘉, 依馬 正次, 小林 和人, 山田 信博, 岩﨑 仁, 島野 仁, 曽根 博仁, 松坂 賢, 矢作 直也, 矢藤 繁, 竹越 一博, 鈴木 浩明, 高橋 昭光, 高橋 智   +31 more
core   +1 more source

Myelin Lipid Composition in the Central Nervous System Is Regionally Distinct and Requires Mechanistic Target of Rapamycin Signaling

Glia, EarlyView.
Brain oligodendrocytes have lower rates of cholesterol synthesis and higher rates of lipoprotein uptake than spinal cord oligodendrocytes. Myelin lipid content is higher in CNS regions with larger average axon diameter. Brain and spinal cord myelin cholesterol content is innately different, while myelin fatty acid content can be modulated by fiber ...
Marie L. Mather, Angelina V. Evangelou, Jennifer N. Bourne, Wendy B. Macklin, Teresa L. Wood   +4 more
wiley   +1 more source

Cholesterol metabolism. Its regulation at the hepatic and intestinal level [PDF]

, 1991
Aunque todas las células del organismo tienen capacidad para sintetizar colesterol, la mayor parte de la síntesis de éste, que da lugar a lo que se conoce como colesterol endógeno, se realiza en el hígado.
Molina, M.T., Ruiz Gutiérrez, Valentina, Vázquez Cueto, Carmen María   +2 more
core  

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes [PDF]

, 2020
BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders.
Davidson, Nicholas O, et al,, Meroni, Marica   +2 more
core   +1 more source

Involvement of fatty acid synthase in dengue virus infection [PDF]

, 2017
BACKGROUND: The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at ...
Duncan R. Smith, Janthima Jaresitthikunchai, Natthida Tongluan, Nitwara Wikan, Nuttaporn Wongsiriroj, Phitchayapak Wintachai, Sarawut Khongwichit, Sittiruk Roytrakul, Supoth Rajakam, Sutee Yoksan, Suwipa Ramphan   +10 more
core   +1 more source