Results 51 to 60 of about 11,790 (158)
Lipids in Health and Disease, 2012 Background Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown.
Schmidt Simone +6 more
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The FASEB Journal, 2015 A key component of eukaryotic lipid homeostasis is the esterification of sterols with fatty acids by sterol O-acyltransferases (SOATs). The esterification reactions are allosterically activated by their sterol substrates, the majority of which accumulate at the plasma membrane.
Sonia Gulati +14 more
openalex +5 more sources
Scientific Reports, 2021 In the current study, APOB (rs1052031) genotype-guided proteomic analysis was performed in a cohort of Pakistani population. A total of 700 study subjects, including Coronary Artery Disease (CAD) patients (n = 480) and healthy individuals (n = 220) as a ...
Muneeza Zafar +10 more
doaj +1 more source
Blocking cholesterol storage to treat Alzheimer’s disease
Exploration of Neuroprotective Therapy, 2021 Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions.
Ta Yuan Chang +6 more
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Animals, 2022 Betaine is a well-established supplement used in livestock feeding. In our previous study, betaine was shown to result in the redistribution of body fat, a healthier steatosis phenotype, and an increased liver weight and triglyceride storage of the ...
Jiying Liu +6 more
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PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Molecular Medicine, 2022 Background Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by which molecules mediate lipid ...
Chanyue Zhao +14 more
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Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. [PDF]
PLoS ONE, 2017 During avian embryonic development, endodermal epithelial cells (EECs) absorb yolk through the yolk sac membrane. Sterol O-acyltransferase (SOAT) is important for esterification and yolk lipid utilization during development.
Siou-Huei Wang +7 more
doaj +1 more source
Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
npj Metabolic Health and DiseasePathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and ...
Syed A. H. Zaidi +2 more
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Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
BMC Cancer, 2021 Background Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved.
Yulong Chen +6 more
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The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology, EarlyView.The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang +5 more
wiley +1 more source