Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]
, 2018 Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael +3 more
core +1 more source
Frontiers in Physiology, 2021 Dietary supplementation of baicalein, a flavonoid, has anti-obesity effects in mammals and broiler chickens. The aim of this study was to determine the effect of dietary baicalein supplementation on broiler growth and adipose tissue and breast muscle ...
Yang Xiao +5 more
doaj +1 more source
Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]
, 2011 F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu +31 more
core +1 more source
Involvement of fatty acid synthase in dengue virus infection [PDF]
, 2017 BACKGROUND: The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at ...
Duncan R. Smith +10 more
core +1 more source
Scientific Reports, 2021 In the current study, APOB (rs1052031) genotype-guided proteomic analysis was performed in a cohort of Pakistani population. A total of 700 study subjects, including Coronary Artery Disease (CAD) patients (n = 480) and healthy individuals (n = 220) as a ...
Muneeza Zafar +10 more
doaj +1 more source
Side-chain oxidized oxysterols as metabolic regulators in liver and brain [PDF]
, 2014 Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half-life and their ability to pass lipophilic membranes easily, thus they are considered as important intermediates in cholesterol excretion pathways and its ...
Ali, Zeina M. F.
core +1 more source
Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]
, 2020 Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian +14 more
core +2 more sources
Blocking cholesterol storage to treat Alzheimer’s disease
Exploration of Neuroprotective Therapy, 2021 Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions.
Ta Yuan Chang +6 more
doaj +1 more source
Interplay between phospholipids and digalactosyldiacylglycerol in phosphate limited oats [PDF]
, 2009 Phosphate is an essential nutrient. In most soils it is limiting, which has resulted in that phosphate is supplied as fertilizer to increase crop yield.
Tjellström, Henrik
core +1 more source
Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
npj Metabolic Health and DiseasePathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and ...
Syed A. H. Zaidi +2 more
doaj +1 more source