Results 71 to 80 of about 12,786 (155)

The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation

Experimental Physiology, EarlyView.
Abstract In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non‐lipid precursors, intrahepatic lipid droplets and recycling ...
Kieran Smith, Kaitlyn M. J. H. Dennis, Leanne Hodson   +2 more
wiley   +1 more source

Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts [PDF]

, 2011
Triacylglycerols (TAG) and steryl esters (SE) are the principal storage lipids in all eukaryotic cells. In yeasts, these storage lipids accumulate within special organelles known as lipid bodies (LB).
A Beopoulos, A Beopoulos, A Dahlqvist, A Laffargue, A Querol, Athanasios Beopoulos, C Gaillardin, C Heier, C Ratledge, C Ratledge, CL Yen, D Sorger, G Barth, G Barth, G Daum, G Daum, G Perrière, J Browse, J Folch, J Sambrook, Jean-Marc Nicaud, JM Nicaud, K Athenstaedt, K Mlickova, L Sandager, P Fickers, P Oelkers, P Oelkers, Philomene Kabran, Ramdane Haddouche, S Dear, S Muller, S Saha, SD Kohlwein, T Czabany, TC Walther, Thierry Chardot, Thierry Dulermo   +37 more
core   +2 more sources

The mood stabilizers lithium and valproate disrupt hepatic and intestinal farnesoid X receptor signalling and increase bile synthesis in the rat

Experimental Physiology, EarlyView.
Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto, Anna V. Golubeva, Alvaro Lopez Gallardo, Thomaz F. S. Bastiaanssen, Alexander V. Zhdanov, Gerard M. Moloney, Caitriona Scaife, Jane A. English, Susan A. Joyce, Timothy G. Dinan, John F. Cryan   +10 more
wiley   +1 more source

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites [PDF]

, 2014
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and production of essential lipid-derived molecules.
Gross, Steven P., Parton, Robert G., Pol, Albert   +2 more
core   +1 more source

Hydroxysteroid 17β‐dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high‐fat diet obese mice

Experimental Physiology, EarlyView.
Abstract Hydroxysteroid 17β‐dehydrogenase 13 (HSD17B13) loss‐of‐function gene variants are associated with a decreased risk of metabolic dysfunction‐associated steatotic liver disease (MASLD). Our RNA‐seq analysis of steatotic liver from obese mice ± fenretinide treatment identified major beneficial effects of fenretinide on expression of hepatic genes
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, Philip D. Whitfield, George D. Mcilroy, Justin J. Rochford, Nimesh Mody   +8 more
wiley   +1 more source

Cholesterol, Bile Acid, And Lipoprotein Metabolism In Two Strains Of Hamster, One Resistant, The Other Sensitive (LPN) To Sucrose-Induced Cholelithiasis [PDF]

, 2000
A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet.
Blanchard, Geraldine, Boehler, Nathalie, Combettes-Souverain, Murielle, Eckhardt, Erik, Ferezou, Jacqueline, Lutton, Claude, Milliat, Fabien, Riottot, Michel, Serougne, Colette, Smith, Jeffery L., Souidi, Maamar   +10 more
core  

Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL [PDF]

, 2015
Accumulation of 7-ketocholesterol (7KCh) in tissues has been previously associated with various chronic aging diseases. Orally ingested 7KCh is readily metabolized by the liver and does not pose a toxicity threat.
Huang, Jiahn-Dar, Lee, Jung Wha, Rodriguez, Ignacio R.   +2 more
core   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda, Mario van der Stelt, Sander Izaak van Kasteren   +2 more
wiley   +1 more source

Mapping condition-dependent regulation of metabolism in yeast through genome-scale modeling [PDF]

, 2013
Background: The genome-scale metabolic model of Saccharomyces cerevisiae, first presented in 2003, was the first genome-scale network reconstruction for a eukaryotic organism.
Bordel, Sergio, Nielsen, Jens, Nookaew, Intawat, Österlund, Tobias   +3 more
core   +1 more source

Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes [PDF]

, 2019
Quercetin (Q) has rapid metabolism, which may make it worthwhile to focus on the potential activity of its metabolites. Our aim was to evaluate the triglyceride-lowering effects of Q metabolites in mature and pre-adipocytes, and to compare them to those ...
Eseberri Barace, Itziar, González Manzano, Susana, Lasa Elguezua, Arrate, Miranda Gómez, Jonatan, Mosqueda Solís, Andrea, Portillo Baquedano, María Puy, Santos Buelga, Celestino   +6 more
core   +2 more sources