Results 71 to 80 of about 19,805 (217)
Blocking cholesterol storage to treat Alzheimer’s disease
Exploration of Neuroprotective Therapy, 2021 Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions.
Ta Yuan Chang +6 more
doaj +1 more source
Side-chain oxidized oxysterols as metabolic regulators in liver and brain [PDF]
, 2014 Oxysterols are oxygenated derivatives of cholesterol characterized by a very short half-life and their ability to pass lipophilic membranes easily, thus they are considered as important intermediates in cholesterol excretion pathways and its ...
Ali, Zeina M. F.
core +1 more source
Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion [PDF]
, 2018 Bio-based production of fatty acids and fatty acid-derived products can enable sustainable substitution of petroleum-derived fuels and chemicals. However, developing new microbial cell factories for producing high levels of fatty acids requires extensive
Ferreira, Raphael +3 more
core +1 more source
Animals, 2022 Betaine is a well-established supplement used in livestock feeding. In our previous study, betaine was shown to result in the redistribution of body fat, a healthier steatosis phenotype, and an increased liver weight and triglyceride storage of the ...
Jiying Liu +6 more
doaj +1 more source
Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization
npj Metabolic Health and DiseasePathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and ...
Syed A. H. Zaidi +2 more
doaj +1 more source
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Molecular Medicine, 2022 Background Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by which molecules mediate lipid ...
Chanyue Zhao +14 more
doaj +1 more source
Advanced Science, EarlyView.Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang +17 more
wiley +1 more source
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
BMC Cancer, 2021 Background Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved.
Yulong Chen +6 more
doaj +1 more source
Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes [PDF]
, 2019 Quercetin (Q) has rapid metabolism, which may make it worthwhile to focus on the potential activity of its metabolites. Our aim was to evaluate the triglyceride-lowering effects of Q metabolites in mature and pre-adipocytes, and to compare them to those ...
Eseberri Barace, Itziar +6 more
core +2 more sources
Advanced Science, EarlyView.This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong +7 more
wiley +1 more source