Results 81 to 90 of about 12,786 (155)

The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2008
Saccharomyces cerevisiae Gup1p is a membrane-bound O-acyltransferase. Previous works involved GUP1 in a wide range of crucial processes for cell preservation and functioning. These include cytoskeleton polarization and secretory/endocytic pathway, GPI-anchor remodelling, wall composition and integrity, and membrane lipids, with a reduction in ...
Célia Ferreira, Cândida Lucas
openaire   +3 more sources

Lipid Droplet‐Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
The article presents the development of artificial lipid droplets (aLDs) as biomimetic nanocarriers to enhance intramuscular fat (IMF) content in pigs. These aLDs, loaded with oleic acid, significantly increase IMF by up to 35% in muscle tissues without adverse side effects. This innovative approach improves pork quality by enhancing marbling, offering
Pengxiang Zhao   +8 more
wiley   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma

open access: yesMolecular Carcinogenesis, Volume 64, Issue 6, Page 1039-1056, June 2025.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao   +6 more
wiley   +1 more source

Tomato UDP-glucose sterol glycosyltransferases: A family of developmental and stress regulated genes that encode cytosolic and membrane-associated forms of the enzyme [PDF]

open access: yes, 2017
Sterol glycosyltransferases (SGTs) catalyze the glycosylation of the free hydroxyl group at C-3 position of sterols to produce sterol glycosides. Glycosylated sterols and free sterols are primarily located in cell membranes where in combination with ...
Altabella Artigas, Teresa   +6 more
core   +2 more sources

Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components

open access: yesModern Agriculture, Volume 3, Issue 1, June 2025.
The regulatory network system of mTOR regulates lactose, milk fat, and milk protein. Milk is urgently needed for the strong development of the dairy industry to meet the growing demand and ensure that the nutritional needs of the world's population are met.
RongNuo Li   +3 more
wiley   +1 more source

The birth and life of lipid droplets: learning from the hepatitis C virus.: Lipid droplets in HCV infection [PDF]

open access: yes, 2011
International audienceLDs (lipid droplets) are probably the least well-characterized cellular organelles. Having long been considered simple lipid storage depots, they are now considered to be dynamic organelles involved in many biological processes ...
Depla, Marion, Roingeard, Philippe
core   +3 more sources

ATP‐binding cassette transporters and sterol O ‐acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification

open access: yesThe FASEB Journal, 2015
A key component of eukaryotic lipid homeostasis is the esterification of sterols with fatty acids by sterol O-acyltransferases (SOATs). The esterification reactions are allosterically activated by their sterol substrates, the majority of which accumulate at the plasma membrane.
Zhongmin A. Guo   +14 more
openaire   +4 more sources

Long‐term effects of metformin on offspring health: A review of current evidence and future directions

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue S3, Page 48-63, June 2025.
Abstract Metformin is widely prescribed for the management of type 2 diabetes mellitus, polycystic ovary syndrome, and gestational diabetes mellitus in pregnancy. Its use is driven by factors including oral administration, lower patient and health system burden and cost, and benefits including lower risk of excess gestational weight gain and ...
Tharaka Mayadunne   +6 more
wiley   +1 more source

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

open access: yes, 2019
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Failing, Klaus   +8 more
core   +1 more source

Management of metabolic dysfunction–associated steatotic liver disease (MASLD)—An expert consensus statement from Indian diabetologists' perspective

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue S4, Page 3-20, June 2025.
Abstract In India, the increasing prevalence of diabetes and obesity poses a significant threat towards a surge in the incidence of metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD).
Abdul Hamid Zargar   +29 more
wiley   +1 more source

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