Results 81 to 90 of about 13,985 (173)
Aging Cell, Volume 25, Issue 3, March 2026.Drosophila and mouse models of Alzheimer's disease exhibit lipid accumulation and neuroinflammation, leading to progressive impairments in memory, locomotion, sleep, circadian rhythms, and synaptic integrity. Knockdown of Dgat2 reduces lipid accumulation and neuroinflammatory signaling, rescuing these deficits and highlighting a conserved, crossspecies
Archana Yadav +7 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 3, Page 1359-1376, March 2026.ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka +6 more
wiley +1 more source
Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity
The Journal of Clinical Investigation, 2023 Sphingolipids function as membrane constituents and signaling molecules, with crucial roles in human diseases, from neurodevelopmental disorders to cancer, best exemplified in the inborn errors of sphingolipid metabolism in lysosomes. The dihydroceramide
Laura Planas-Serra +18 more
doaj +1 more source
Plant Biotechnology Journal, Volume 24, Issue 3, Page 1322-1343, March 2026.ABSTRACT Lipid droplets (LDs) serve as the primary storage site for neutral lipids in plant cells, with growing evidence supporting many additional biological roles, such as in lipid homeostasis, signalling, trafficking, inflammatory responses and inter‐organelle communication.
Abdulsamie Hanano +2 more
wiley +1 more source
Molecular insights into volatile organic compound sensing and signaling in plants
The Plant Journal, Volume 125, Issue 6, March 2026.SUMMARY Plants interact with their surrounding environment through the perception of a vast and structurally diverse array of volatile organic compounds (VOCs); however, the molecular mechanisms involved remain mostly unknown. Despite the large number of VOCs emitted and perceived by plants, only a small number of phylogenetically distinct, but often ...
Matthew E. Bergman +4 more
wiley +1 more source
Breast Cancer ResearchSignaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells.
Jennifer E. Tuokkola +6 more
doaj +1 more source
Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Pan et al. demonstrate that disruption of hepatic insulin signaling by insulin receptor (IR) substrate (IRS1/2) deletion led to impaired PI3K‐AKT signaling, causing increased Foxo1 activation and TGF‐β1 expression, which dysregulated the expression of the key enzymes involving phospholipid biosynthesis and remodeling.
Quan Pan +6 more
wiley +1 more source
Communications BiologyWolfiporia cocos is a medicinal mushroom used in China. It biosynthesizes pachymic acid (PA), a main therapeutic triterpene associated with therapies. Nowadays, the unknown PA biosynthesis leads to difficulties in increasing its content in W.
Heping Liu +13 more
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Nature CommunicationsThe cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex ...
Bao-cun Zhang +20 more
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Nature CommunicationsImmune functions decline with aging, leading to increased susceptibility to various diseases including tumors. Exploring aging-related molecular targets in elderly patients with cancer is thus highly sought after.
Mingjiong Zhang +13 more
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