Results 81 to 90 of about 19,805 (217)
Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation
Advanced Science, EarlyView.A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo +10 more
wiley +1 more source
Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. [PDF]
PLoS ONE, 2017 During avian embryonic development, endodermal epithelial cells (EECs) absorb yolk through the yolk sac membrane. Sterol O-acyltransferase (SOAT) is important for esterification and yolk lipid utilization during development.
Siou-Huei Wang +7 more
doaj +1 more source
Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency [PDF]
, 2005 Affiliation: CHU-Sainte-Justine, Université de MontréalTransport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are ...
Drouin, Éric +3 more
core +2 more sources
Advanced Science, EarlyView.This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang +7 more
wiley +1 more source
Cells, 2021 7-Ketocholesterol (7KCh) is a major oxidized cholesterol product abundant in lipoprotein deposits and atherosclerotic plaques. Our previous study has shown that 7KCh accumulates in erythrocytes of heart failure patients, and further investigation ...
Mei-Ling Cheng +6 more
doaj +1 more source
The birth and life of lipid droplets: learning from the hepatitis C virus.: Lipid droplets in HCV infection [PDF]
, 2011 International audienceLDs (lipid droplets) are probably the least well-characterized cellular organelles. Having long been considered simple lipid storage depots, they are now considered to be dynamic organelles involved in many biological processes ...
Depla, Marion, Roingeard, Philippe
core +3 more sources
Advanced Science, EarlyView.Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen +8 more
wiley +1 more source
Cholesterol metabolism. Its regulation at the hepatic and intestinal level [PDF]
, 1991 Aunque todas las células del organismo tienen capacidad para sintetizar colesterol, la mayor parte de la síntesis de éste, que da lugar a lo que se conoce como colesterol endógeno, se realiza en el hígado.
Molina, M.T. +2 more
core
Food Frontiers, EarlyView.Sodium selenite or vitamin E supplementation enhances antioxidant defenses in mouse mammary glands, reducing oxidative stress, lipid peroxidation, and iron accumulation. This boosts GPX4 activity, inhibits PTGS2, and activates mTORC1, improving milk fat droplet formation and protein synthesis, with the combined treatment showing the greatest benefit ...
Qianzi Zhang +7 more
wiley +1 more source
Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. [PDF]
PLoS ONE, 2011 We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E ...
Zongji Lu +6 more
doaj +1 more source