Results 81 to 90 of about 14,545 (218)
Food Frontiers, EarlyView.ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
The birth and life of lipid droplets: learning from the hepatitis C virus.: Lipid droplets in HCV infection [PDF]
, 2011 International audienceLDs (lipid droplets) are probably the least well-characterized cellular organelles. Having long been considered simple lipid storage depots, they are now considered to be dynamic organelles involved in many biological processes ...
Depla, Marion, Roingeard, Philippe
core +3 more sources
Cholesterol metabolism. Its regulation at the hepatic and intestinal level [PDF]
, 1991 Aunque todas las células del organismo tienen capacidad para sintetizar colesterol, la mayor parte de la síntesis de éste, que da lugar a lo que se conoce como colesterol endógeno, se realiza en el hígado.
Molina, M.T. +2 more
core
International Journal of Cancer, EarlyView.What's New? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan +14 more
wiley +1 more source
Nanoparticle-based siRNA Delivery System in Intestine Empowers the Obesity Management
Nano Biomedicine and EngineeringWe highlighted a poly lactic acid-co-glycolic acid (PLGA)-block-polyethylene glycol (PEG) and chitosan-based nanoparticle system to deliver sterol O-acyltransferase 2 (SOAT2) siRNAs into the small intestines of mice to effectively inhibit lipid uptake ...
Jianshe Yang
doaj +1 more source
Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease [PDF]
, 2014 Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of metabolic abnormalities ranging from simple hepatic steatosis (accumulation of neutral lipid) to development of steatotic lesions, steatohepatitis, and cirrhosis.
Finck, Brian N, Schweitzer, George G
core +3 more sources
iMetaOmics, EarlyView.First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang +9 more
wiley +1 more source
Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. [PDF]
PLoS ONE, 2011 We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E ...
Zongji Lu +6 more
doaj +1 more source
Cells, 2021 7-Ketocholesterol (7KCh) is a major oxidized cholesterol product abundant in lipoprotein deposits and atherosclerotic plaques. Our previous study has shown that 7KCh accumulates in erythrocytes of heart failure patients, and further investigation ...
Mei-Ling Cheng +6 more
doaj +1 more source
The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease [PDF]
, 2015 Background Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production and de novo lipogenesis. Persistent organic pollutants (POPs)
Caroline Lefebvre +2 more
core +1 more source