Results 111 to 120 of about 20,141 (153)

The proteotranscriptomic characterization of venom in the white seafan <i>Eunicella singularis</i> elucidates the evolution of Octocorallia arsenal. [PDF]

Open Biol
Modica MV, Leone S, Gerdol M, Greco S, Aurelle D, Oliverio M, Fassio G, El Koulali K, Barrachina C, Dutertre S.   +9 more
europepmc   +1 more source

Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments. [PDF]

Sci Adv
Arranz R, Santiago C, Masiulis S, Rivera-de-Torre E, Palacios-Ortega J, Carlero D, Heras-Márquez D, Gavilanes JG, Arias-Palomo E, Martínez-Del-Pozo Á, García-Linares S, Martín-Benito J.   +11 more
europepmc   +1 more source

KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers. [PDF]

J Biol Chem
Szekér P, Bodó T, Klima K, Csóti Á, Hanh NN, Murányi J, Hajdara A, Szántó TG, Panyi G, Megyeri M, Péterfi Z, Farkas S, Gyöngyösi N, Hornyák P.   +13 more
europepmc   +1 more source

A novel spider toxin as a selective antagonist of the Kv1 subfamily of voltage-gated potassium channels through gating modulation. [PDF]

J Biol Chem
Xiao Z, You X, Chen M, Li H, Chen B, Hu Z, You Q, Liu H, Zhao P, Zhou X, Liu Z.   +10 more
europepmc   +1 more source

The action mechanism of actinoporins revealed through the structure of pore-forming intermediates

Arranz R, Santiago C, Masiulis S, Rivera-de-Torre E, Palacios-Ortega J, Carlero D, Heras-Márquez D, Gavilanes JG, Arias-Palomo E, Martínez-del-Pozo Á, García-Linares S, Martín-Benito J.   +11 more
europepmc   +1 more source

Purification and characterization of two hemolysins from Stichodactyla helianthus

Toxicon, 2001
Two hemolysins, Sticholysin I (St I) and Sticholysin II (St II) were purified from the sea anemone Stichodactyla helianthus combining gel filtration and ion exchange chromatography. The amino acid composition of both cytolysins was determined revealing a high proportion of glycine, lysine, tyrosine and non-polar amino acids (alanine, leucine and valine)
Vivian Morera, CARLOS Alvarez, Mayra Tejuca   +2 more
exaly   +5 more sources

Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.

Toxicon, 1995
A peptide toxin, ShK, that blocks voltage-dependent potassium channels was isolated from the whole body extract of the Caribbean sea anemone Stichodactyla helianthus. It competes with dendrotoxin I and alpha-dendrotoxin for binding to synaptosomal membranes of rat brain, facilities acetylcholine release at an avian neuromuscular junction and suppresses
Olga Castañeda, V. Sotolongo, A. M. Amor, R. Stöcklin, A. Anderson, Alan L. Harvey, Åke Engström, Christer Wernstedt, Evert Karlsson   +8 more
semanticscholar   +6 more sources

One single salt bridge explains the different cytolytic activities shown by actinoporins sticholysin I and II from the venom of Stichodactyla helianthus

Archives of Biochemistry and Biophysics, 2017
Sticholysins I and II (StnI and StnII), α-pore forming toxins from the sea anemone Stichodactyla helianthus, are water-soluble toxic proteins which upon interaction with lipid membranes of specific composition bind to the bilayer, extend and insert their
Esperanza Rivera-De-Torre, Juan Palacios-Ortega, Sara García-Linares   +2 more
exaly   +3 more sources

Properties of St I and St II, two isotoxins isolated from Stichodactyla helianthus: a comparison

Toxicon, 2001
Sticholysins I and II are two highly hemolytic polypeptides purified from the Caribbean Sea anemone Stichodactyla helianthus. Their high sequence homology (93%) indicates that they correspond to isoforms of the same hemolysin. The spectroscopic measurements show a close similarity in the secondary structure content, conformation and stability of both ...
Diana Martinez, F Pazos, CARLOS Alvarez   +2 more
exaly   +6 more sources

Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels

Molecular Pharmacology, 2005
Voltage-gated potassium (Kv) channels regulate many physiological functions and represent important therapeutic targets in the treatment of several clinical disorders. Although some of these channels have been well-characterized, the study of others, such as Kv3 channels, has been hindered because of limited pharmacological tools. The current study was
Lizhen Yan, J. Herrington, Ethan M. Goldberg, P. Dulski, R. Bugianesi, R. S. Slaughter, Priya Banerjee, R. Brochu, B. Priest, G. Kaczorowski, B. Rudy, Maria L. Garcia   +11 more
semanticscholar   +4 more sources