Results 181 to 190 of about 34,534 (295)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

The inhibition mechanism of ultrasonic vibration on stick-slip phenomenon of sliding friction pair. [PDF]

Sci Rep
Luo L, Li N, Li Q, Cheng Z, Wang B, Long W, Zhao B.   +6 more
europepmc   +1 more source

A Novel Stick-Slip Nanopositioning Stage Integrated with a Flexure Hinge-Based Friction Force Adjusting Structure. [PDF]

Micromachines (Basel), 2020
Zhu J, Zhu J, Pan P, Wang Y, Gu S, Zhai R, Pang M, Liu X, Ru C.   +8 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Measurement and Analysis of Stick-Slip and High-Frequency Torsional Coupled Oscillations of Drill String

Shiyou jixie
The self-excited torsional oscillation of the drilling system can reduce the contact force between the bit and the formation or the relative velocity of the cutting force.To mitigate the impact of this mechanism,the torsional oscillation of the drill ...
Li Yumei, Deng Yanglin, Zhang Tao, Yu Liwei, Liu Ming   +4 more
doaj  

Stick-slip unfolding favors self-association of expanded HTT mRNA. [PDF]

Nat Commun
O'Brien BM, Moulick R, Jiménez-Avalos G, Rajasekaran N, Kaiser CM, Woodson SA.   +5 more
europepmc   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Unique stick-slip crack dynamics of double-network hydrogels under pure-shear loading. [PDF]

Proc Natl Acad Sci U S A
Zheng Y, Wang Y, Tian F, Nakajima T, Hui CY, Gong JP.   +5 more
europepmc   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Energy store & release facilitating movement in stick & slip friction, animal jump, and earthquake. [PDF]

Sci Rep
Bejan A.
europepmc   +1 more source