Results 91 to 100 of about 163,843 (288)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Stiff-person syndrome – a literature review

Aktualności Neurologiczne, 2019
Stiff-person syndrome, also known as stiff-man syndrome (SMS) or the Moersch–Woltman syndrome, was first described in 1956. The disease is rare. The estimated prevalence in the general population is 1–2 cases/1,000,000, and the annual incidence is 1 case
Karol Jastrzębski
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Influence of variety and processing methods on the sensory characteristics and consumer acceptance of stiff porridge prepared from sorghum (Sorghum bicolor L. Moench)

Frontiers in Sustainable Food Systems
IntroductionSorghum is an underutilised and neglected crop in Malawi. The study assessed how sorghum varieties and processing methods affect the sensory characteristics and consumer acceptance of stiff porridge.MethodsThree sorghum varieties, namely ...
Stella C. Mlewa, Vincent Mlotha, Moses F. A. Maliro, Agnes M. Mwangwela   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

How to manage a native stiff knee

EFORT Open Reviews
Knee stiffness is a widely known and worrying condition in several postoperative knees. Less is known about native stiff knee. The aim of this manuscript is to summarize the available literature on native stiff knee epidemiology, classification and ...
Francesco Pirato, Federica Rosso, Federico Dettoni, Davide Edoardo Bonasia, Matteo Bruzzone, Roberto Rossi   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tropomodulin1 regulates the biomechanical changes in macrophages induced by matrix stiffness

Mechanobiology in Medicine
The monocyte/macrophage infiltration plays critical roles in the development of atherosclerosis. Arterial stiffness is a cholesterol-independent risk factor for cardiovascular events.
Yajun Meng, Amannisa Tuersuntuoheti, Siyu Jiang, Jiayi Xie, Zejun Yue, Dingwen Xu, Xueyu Geng, Xiang Lian, Lide Xie, Lanping Amy Sung, Xifu Wang, Jing Zhou, Weijuan Yao   +12 more
doaj   +1 more source